Physicians

Departments / Divisions

• Surgery / Neurosurgery
• Neurobiology

Address
DUMC 3807
Durham, NC 27710

Appointment Telephone
919-684-6706

Office Telephone
919-684-6706

Fax Telephone
919-681-8068

Training

• MD, Indiana University School of Medicine, 1975

Residency

• Neurosurgery, University of Washington Medical Center, 1976-1981

Fellowship

• Neurophysiology, Institute for Neurophysiology and University Hospital, University of Oslo (Norway), 1981-1982

Clinical Interests
Movement disorders, stereotactic neurosurgery, complex spine abnormalities, general adult neurosurgery

Research Interests
Current clinical research interests include clinical trials in Parkinson's disease, Alzheimer's disease, deep brain stimulation for depression, and sensory restoration for development of brain machine interfaces.  Clinical treatments include deep brain stimulation, which is now a common procedure for treating Parkinson's disease and tremor.  Basic science research interests focus on evaluation of metabolism changes with aging, particularly in response to ischemia and hypoglycemia, as well as epilepsy and seizure mechanisms as functions of both post-lesion injury and aging brain.  These basic science interests include new approaches to optical imaging of the brain, cellular understanding of metabolism using direct substrate recordings (ie, oxygen, glucose, lactate) and developing new methods to understand complex interactions between neurons, astrocytes and blood vessels.  

Industry Relationships and Collaborations (What's this?)

This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Alnylam Pharmaceutical, Inc.
• Ceregene, Inc.
• Medtronic Inc.
• Taylor and Francis Group (Informa)

Representative Publications
Galeffi F, Somjen GG, Foster KA, Turner DA. Simultaneous monitoring of tissue PO(2) and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices.  J Cereb Blood Flow Metab.  2010 Aug 25. (2010) Abstract

Gollub RL, Turner DA. Neuroinformatics in clinical and translational medicine--novel approaches.  Neuroinformatics.  2010 Dec;8(4):207-12. (2010) Abstract

Marks WJ Jr, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower JH, Olanow CW. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.  Lancet Neurol.  2010 Dec;9(12):1164-72. (2010) Abstract

Rizk M, Bossetti CA, Jochum TA, Callender SH, Nicolelis MA, Turner DA, Wolf PD. A fully implantable 96-channel neural data acquisition system.  J Neural Eng.  2009 Apr;6(2):026002. (2009) Abstract

Birdno MJ, Kuncel AM, Dorval AD, Turner DA, Grill WM. Tremor varies as a function of the temporal regularity of deep brain stimulation.  Neuroreport.  2008 Mar 26;19(5):599-602. (2008) Abstract

Foster KA, Margraf RR, Turner DA. NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia.  Neurobiol Aging.  2008 Apr;29(4):598-613. (2008) Abstract

Patil PG, Turner DA. The development of brain-machine interface neuroprosthetic devices.  Neurotherapeutics.  2008 Jan;5(1):137-46. (2008) Abstract

Galeffi F, Foster KA, Sadgrove MP, Beaver CJ, Turner DA. Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices.  J Neurochem.  2007 Dec;103(6):2449-61. (2007) Abstract

Sadgrove MP, Beaver CJ, Turner DA. Effects of relative hypoglycemia on LTP and NADH imaging in rat hippocampal slices.  Brain Res.  2007 Aug 24;1165:30-9. (2007) Abstract

Foster KA, Galeffi F, Gerich FJ, Turner DA, Müller M. Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration. Prog Neurobiol. 2006 Jun;79(3):136-71. (2006) Abstract

Lang AE, Gill S, Patel NK, Lozano A, Nutt JG, Penn R, Brooks DJ, Hotton G, Moro E, Heywood P, Brodsky MA, Burchiel K, Kelly P, Dalvi A, Scott B, Stacy M, Turner D, Wooten VG, Elias WJ, Laws ER, Dhawan V, Stoessl AJ, Matcham J, Coffey RJ, Traub M. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease.  Ann Neurol.  2006 Mar;59(3):459-66. (2006) Abstract

Foster KA, Beaver CJ, Turner DA. Interaction between tissue oxygen tension and NADH imaging during synaptic stimulation and hypoxia in rat hippocampal slices. Neuroscience. 2005;132(3):645-57. (2005) Abstract

Patil PG, Turner DA, Pietrobon R. National trends in surgical procedures for degenerative cervical spine disease: 1990-2000. Neurosurgery. 2005 Oct;57(4):753-8; discussion 753-8. (2005) Abstract

Patil PG, Carmena JM, Nicolelis MA, Turner DA. Ensemble recordings of human subcortical neurons as a source of motor control signals for a brain-machine interface. Neurosurgery. 2004 Jul;55(1):27-35; discussion 35-8. (2004) Abstract

Smith-Hammond CA, New KC, Pietrobon R, Curtis DJ, Scharver CH, Turner DA. Prospective analysis of incidence and risk factors of dysphagia in spine surgery patients: comparison of anterior cervical, posterior cervical, and lumbar procedures. Spine (Phila Pa 1976). 2004 Jul 1;29(13):1441-6. (2004) Abstract

Turner DA (editor).  Modern Neurosurgery: Clinical Translation of Neuroscience Advances.  CRC Press, New York, 2004.  Includes 16 chapters, and 11 co-authored chapters (2004)

Turner DA, Shetty AK. Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy. Neurosurgery. 2003 Mar;52(3):632-44; discussion 641-4. (2003) Abstract

Fayuk D, Aitken PG, Somjen GG, Turner DA. Two different mechanisms underlie reversible, intrinsic optical signals in rat hippocampal slices. J Neurophysiol. 2002 Apr;87(4):1924-37. (2002) Abstract

Speciale AC, Pietrobon R, Urban CW, Richardson WJ, Helms CA, Major N, Enterline D, Hey L, Haglund M, Turner DA. Observer variability in assessing lumbar spinal stenosis severity on magnetic resonance imaging and its relation to cross-sectional spinal canal area. Spine. 2002 May 15;27(10):1082-6. (2002) Abstract

Danisa OA, Turner D, Richardson WJ. Surgical correction of lumbar kyphotic deformity: posterior reduction "eggshell" osteotomy. J Neurosurg Spine. 2000 Jan;92(1):50-6. (2000) Abstract