Medical Director, Lung Transplant and Heart-Lung Transplant Programs

Department / Division:
Medicine / Pulmonary, Allergy, and Critical Care Medicine

Address:
DUMC Box 102354
Durham, NC 27710

Office Telephone:
919-684-2728

Fax Telephone:
919-684-3067

• MD, Northwestern University Feinberg School of Medicine (Illinois), 1998

• Internal Medicine, Johns Hopkins Hospital (Maryland), 1998-2001

• Pulmonary and Critical Care, Duke University Medical Center, 2001-2005

• MBA, Duke University, 2008

Clinical Interests:
Lung transplantation

Research Interests:
Dr. Zaas's research includes clinical, translational and basic research investigation centered on the care of lung transplant patients.  His basic research has focused on the host pathogen interactions of Pseudomonas pneumonia, which is a frequent post-transplant infection believed to contribute to the progression of bronchiolitis obliterans syndrome.  He is involved in a wide range of clinical research investigations aimed at improving the practice of lung transplantation.  Specific areas of interest include resource utilization and clinical outcomes after lung transplantation.  Dr. Zaas is also actively involved in transplant policy through his involvement with the United Network for Organ Sharing as well as the HRSA Transplant Collaborative.

Representative Publications:
Zaas DW. Update on medical complications involving the lungs. Curr Opin Organ Transplant. 2009 Jul 17. (2009) Abstract

Zaas DW, Swan ZD, Brown BJ, Li G, Randell SH, Degan S, Sunday ME, Wright JR, Abraham SN. Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. J Biol Chem. 2009 Apr 10;284(15):9955-64. (2009) Abstract

Todd JL, Lakey J, Howell D, Reidy M, Zaas D. Portal hypertension and granulomatous liver disease in a lung transplant recipient due to disseminated atypical mycobacterial infection. Am J Transplant. 2007 May;7(5):1300-3. (2007) Abstract

Reams BD, Musselwhite LW, Zaas DW, Steele MP, Garantziotis S, Eu PC, Snyder LD, Curl J, Lin SS, Davis RD, Palmer SM. Alemtuzumab in the treatment of refractory acute rejection and bronchiolitis obliterans syndrome after human lung transplantation. Am J Transplant. 2007 Dec;7(12):2802-8. (2007) Abstract

Bishop BL, Duncan MJ, Song J, Li G, Zaas D, Abraham SN. Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. Nat Med. 2007 May;13(5):625-30. (2007) Abstract

Zaas DW, Duncan MJ, Li G, Wright JR, Abraham SN. Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. J Biol Chem. 2005 Feb 11;280(6):4864-72. (2005) Abstract

Zaas DW, Duncan M, Rae Wright J, Abraham SN. The role of lipid rafts in the pathogenesis of bacterial infections. Biochim Biophys Acta. 2005 Dec 30;1746(3):305-13. (2005) Abstract

Abraham SN, Duncan MJ, Li G, Zaas D. Bacterial penetration of the mucosal barrier by targeting lipid rafts. J Investig Med. 2005 Sep;53(6):318-21. (2005) Abstract

Zaas D, Wise R, Wiener C, . Airway obstruction is common but unsuspected in patients admitted to a general medicine service. Chest. 2004 Jan;125(1):106-11. (2004) Abstract

Zaas D, Schwartz DA. Genetics of environmental asthma. Semin Respir Crit Care Med. 2003 Apr;24(2):185-96. (2003) Abstract

Zaas D, Palmer SM. Respiratory failure early after lung transplantation: now that we know the extent of the problem, what are the solutions? Chest. 2003 Jan;123(1):14-6. (2003) Abstract

Zaas D, Brock M, Yang S, Sylvester JT. An uncommon mimic of an acute asthma exacerbation. Chest. 2002 May;121(5):1707-9. (2002) Abstract

O'Gorman MR, Bianchi L, Zaas D, Corrochano V, Pachman LM. Decreased levels of CD54 (ICAM-1)-positive lymphocytes in the peripheral blood in untreated patients with active juvenile dermatomyositis. Clin Diagn Lab Immunol. 2000 Jul;7(4):693-7. (2000) Abstract

O'Gorman MR, Zaas D, Paniagua M, Corrochano V, Scholl PR, Pachman LM. Development of a rapid whole blood flow cytometry procedure for the diagnosis of X-linked hyper-IgM syndrome patients and carriers. Clin Immunol Immunopathol. 1997 Nov;85(2):172-81. (1997) Abstract