Physicians

Chief Medical Officer, Private Diagnostic Clinic
Vice-Chair for Clinical Practice, Department of Medicine
Medical Director, Lung Transplant Program

Department / Division
Medicine / Medicine-Pulmonary

Address
DUMC Box 3703
Durham, NC 27710

Appointment Telephone
919-684-2240

Office Telephone
919-613-6877

Fax Telephone
919-681-9571

Training

• MD, Northwestern University Feinberg School of Medicine (Illinois), 1998

Residency

• Internal Medicine, Johns Hopkins Hospital (Maryland), 1998-2001

Fellowship

• Pulmonary and Critical Care, Duke University Medical Center, 2001-2005

Other Training

• MBA, Duke University, 2008

Clinical Interests
Lung transplantation

Research Interests
Dr. Zaas's research includes clinical, translational and basic research investigation centered on the care of lung transplant patients.  His basic research has focused on the host pathogen interactions of Pseudomonas pneumonia, which is a frequent post-transplant infection believed to contribute to the progression of bronchiolitis obliterans syndrome.  He is involved in a wide range of clinical research investigations aimed at improving the practice of lung transplantation.  Specific areas of interest include resource utilization and clinical outcomes after lung transplantation.  Dr. Zaas is also actively involved in transplant policy through his involvement with the United Network for Organ Sharing as well as the HRSA Transplant Collaborative.

Industry Relationships and Collaborations (What's this?)

This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• APT pharmaceuticals
• Johnson & Johnson
• Pfizer Inc.

Representative Publications
Finlen Copeland CA, Snyder LD, Zaas DW, Turbyfill WJ, Davis WA, Palmer SM. Survival After Bronchiolitis Obliterans Syndrome Among Bilateral Lung Transplant Recipients. Am J Respir Crit Care Med. 2010 May 27. (2010) Abstract

Lease ED, Zaas DW. Complex bacterial infections pre- and posttransplant. Semin Respir Crit Care Med. 2010 Apr;31(2):234-42. (2010) Abstract

Hartwig MG, Snyder LD, Finlen-Copeland A, Lin SS, Zaas DW, Davis RD, Palmer SM. Lung transplantation at Duke University. Clin Transpl. 2009:197-210. (2009) Abstract

Zaas DW, Swan Z, Brown BJ, Wright JR, Abraham SN. The expanding roles of caveolin proteins in microbial pathogenesis. Commun Integr Biol. 2009 Nov;2(6):535-7. (2009) Abstract

Zaas DW, Swan ZD, Brown BJ, Li G, Randell SH, Degan S, Sunday ME, Wright JR, Abraham SN. Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. J Biol Chem. 2009 Apr 10;284(15):9955-64. (2009) Abstract

Zaas DW. Update on medical complications involving the lungs. Curr Opin Organ Transplant. 2009 Jul 17. (2009) Abstract

Bishop BL, Duncan MJ, Song J, Li G, Zaas D, Abraham SN. Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. Nat Med. 2007 May;13(5):625-30. (2007) Abstract

Reams BD, Musselwhite LW, Zaas DW, Steele MP, Garantziotis S, Eu PC, Snyder LD, Curl J, Lin SS, Davis RD, Palmer SM. Alemtuzumab in the treatment of refractory acute rejection and bronchiolitis obliterans syndrome after human lung transplantation. Am J Transplant. 2007 Dec;7(12):2802-8. (2007) Abstract

Todd JL, Lakey J, Howell D, Reidy M, Zaas D. Portal hypertension and granulomatous liver disease in a lung transplant recipient due to disseminated atypical mycobacterial infection. Am J Transplant. 2007 May;7(5):1300-3. (2007) Abstract

Abraham SN, Duncan MJ, Li G, Zaas D. Bacterial penetration of the mucosal barrier by targeting lipid rafts. J Investig Med. 2005 Sep;53(6):318-21. (2005) Abstract

Zaas DW, Duncan M, Rae Wright J, Abraham SN. The role of lipid rafts in the pathogenesis of bacterial infections. Biochim Biophys Acta. 2005 Dec 30;1746(3):305-13. (2005) Abstract

Zaas DW, Duncan MJ, Li G, Wright JR, Abraham SN. Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. J Biol Chem. 2005 Feb 11;280(6):4864-72. (2005) Abstract

Zaas D, Wise R, Wiener C, . Airway obstruction is common but unsuspected in patients admitted to a general medicine service. Chest. 2004 Jan;125(1):106-11. (2004) Abstract

Zaas D, Palmer SM. Respiratory failure early after lung transplantation: now that we know the extent of the problem, what are the solutions? Chest. 2003 Jan;123(1):14-6. (2003) Abstract

Zaas D, Schwartz DA. Genetics of environmental asthma. Semin Respir Crit Care Med. 2003 Apr;24(2):185-96. (2003) Abstract