Physicians

Chief Medical Officer, Private Diagnostic Clinic
Vice-Chair for Clinical Practice, Department of Medicine
Medical Director, Lung Transplant Program

Department / Division
Medicine / Medicine-Pulmonary

Address
DUMC Box 3810
Durham, NC 27710

Appointment Telephone
919-684-2240

Office Telephone
919-613-6877

Fax Telephone
919-681-9571

Training

• MD, Northwestern University Feinberg School of Medicine (Illinois), 1998

Residency

• Internal Medicine, Johns Hopkins Hospital (Maryland), 1998-2001

Fellowship

• Pulmonary and Critical Care, Duke University Medical Center, 2001-2005

Other Training

• MBA, Duke University, 2008

Clinical Interests
Lung transplantation

Research Interests
Dr. Zaas's research includes clinical, translational and basic research investigation centered on the care of lung transplant patients. His basic research has focused on the host pathogen interactions of Pseudomonas pneumonia, which is a frequent post-transplant infection believed to contribute to the progression of bronchiolitis obliterans syndrome. He is involved in a wide range of clinical research investigations aimed at improving the practice of lung transplantation. Specific areas of interest include resource utilization and clinical outcomes after lung transplantation. Dr. Zaas is also actively involved in transplant policy through his involvement with the United Network for Organ Sharing as well as the HRSA Transplant Collaborative.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Covance
• Elsevier
• UpToDate

Representative Publications
Finlen Copeland, CA; Snyder, LD; Zaas, DW; Turbyfill, WJ; Davis, WA; Palmer, SM. Survival after bronchiolitis obliterans syndrome among bilateral lung transplant recipients. American Journal of Respiratory and Critical Care Medicine. 2010;182:784-789. (2010) Abstract

Lease, ED; Zaas, DW. Complex bacterial infections pre- and posttransplant. Seminars in Respiratory and Critical Care Medicine: pulmonology, critical care, allergy and immunology, infections. 2010;31:234-242. (2010) Abstract

Hartwig, MG; Snyder, LD; Finlen-Copeland, A; Lin, SS; Zaas, DW; Davis, RD; Palmer, SM. Lung transplantation at Duke University. Clinical transplants. 2009;197-210. (2009) Abstract

Zaas, DW. Update on medical complications involving the lungs. Current Opinion in Organ Transplantation. 2009;14:488-493. (2009) Abstract

Zaas, DW; Swan, Z; Brown, BJ; Wright, JR; Abraham, SN. The expanding roles of caveolin proteins in microbial pathogenesis. Communitative and Integrative Biology. 2009;2:535-537. (2009) Abstract

Zaas, DW; Swan, ZD; Brown, BJ; Li, G; Randell, SH; Degan, S; Sunday, ME; Wright, JR; Abraham, SN. Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. Journal of Biological Chemistry. 2009;284:9955-9964. (2009) Abstract

Bishop, BL; Duncan, MJ; Song, J; Li, G; Zaas, D; Abraham, SN. Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. Nature Medicine. 2007;13:625-630. (2007) Abstract

Reams, BD; Musselwhite, LW; Zaas, DW; Steele, MP; Garantziotis, S; Eu, PC; Snyder, LD; Curl, J; Lin, SS; Davis, RD; Palmer, SM. Alemtuzumab in the treatment of refractory acute rejection and bronchiolitis obliterans syndrome after human lung transplantation. American Journal of Transplantation. 2007;7:2802-2808. (2007) Abstract

Todd, JL; Lakey, J; Howell, D; Reidy, M; Zaas, D. Portal hypertension and granulomatous liver disease in a lung transplant recipient due to disseminated atypical mycobacterial infection. American Journal of Transplantation. 2007;7:1300-1303. (2007) Abstract

Abraham, SN; Duncan, MJ; Li, G; Zaas, D. Bacterial penetration of the mucosal barrier by targeting lipid rafts. Journal of Investigative Medicine. 2005;53:318-321. (2005) Abstract

Zaas, DW; Duncan, M; Rae Wright, J; Abraham, SN. The role of lipid rafts in the pathogenesis of bacterial infections. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 2005;1746:305-313. (2005) Abstract

Zaas, DW; Duncan, MJ; Li, G; Wright, JR; Abraham, SN. Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. Journal of Biological Chemistry. 2005;280:4864-4872. (2005) Abstract

Zaas, D; Wise, R; Wiener, C; Longcope Spirometry Invetigation Team. Airway obstruction is common but unsuspected in patients admitted to a general medicine service. Chest. 2004;125:106-111. (2004) Abstract

Zaas, D; Palmer, SM. Respiratory failure early after lung transplantation: now that we know the extent of the problem, what are the solutions?. Chest. 2003;123:14-16. (2003) Abstract

Zaas, D; Schwartz, DA. Genetics of environmental asthma. Seminars in Respiratory and Critical Care Medicine: pulmonology, critical care, allergy and immunology, infections. 2003;24:185-196. (2003) Abstract