Welcome to DukeHealth.org.
Skip over navigation
  • Home
  • Patient and Visitor Info
  • Physicians
  • Services
  • Clinical Trials
  • Event Calendar
  • Locations
  • Health Library
  • About Duke Medicine

Quick Links

  • Appointments
  • Quality and Safety
Home > Physicians > Epstein, David L.
Jumbo Large Regular Text:
Print
Physicians

David L. Epstein, MD, MMM

Related Content

Video

Duke Eye Center: Your Vision for the Future

Health Articles

Eye Center Receives $100,000 Research to Prevent Blindness Grant

The Glaucoma Detectives

Duke Receives Research to Prevent Blindness Grants

Locations

  • Duke Eye Center

Services

  • Glaucoma

Share

David L. Epstein, MD, MMM

Chair, Department of Ophthalmology

Department / Division
Ophthalmology / Glaucoma Ophthalmology

Address
DUMC 3802
Durham, NC 27710

Office Telephone
919-684-6611

Fax Telephone
919-681-6343

Training
  • MD, Johns Hopkins University School of Medicine (Maryland), 1968

Residency
  • Glaucoma, Massachusetts Eye and Ear Infirmary, 1973-1975

Fellowship
  • Glaucoma, Massachusetts Eye and Ear Infirmary, 1975-1976

Other Training
  • MMM, Tulane University School of Public Health (Louisiana), 2001

Clinical Interests
Glaucoma consultation

Research Interests
My research is focused on developing novel specific treatments for glaucoma that are directed at the trabecular meshwork, the tissue that is known to be abnormal in glaucoma, causing increased resistance to outflow of aqueous humor from the anterior chamber of the eye. Methods include modern cell biological and molecular techniques to study both the tissue and cells of the outflow pathway in vitro and in vivo. There is an emphasis on the influence of the cytoskeleton on aqueous humor outflow function. In addition, recent work of the laboratory has focused on gene expression during elevations of intraocular pressure or mechanical stretch, with the goal of identifying key homeostatic influences on aqueous humor outflow resistance that might lead to novel therapies for glaucoma. A current hypothesis is that proteasome dysfunction might be involved in the cellular aging that leads to glaucoma.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

  • Aerie Pharmaceuticals, Inc.
  • Allergan, Inc.
  • Glaukos Corporation
  • GrayBug, LLC
  • HyperBranch Medical Technology
  • Retroject, Inc.

Representative Publications
Li, G; Luna, C; Navarro, ID; Epstein, DL; Huang, W; Gonzalez, P; Challa, P. Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity. Investigative Ophthalmology and Visual Science. 2011;52:4395-4401. (2011) Abstract

Li, G; Luna, C; Qiu, J; Epstein, DL; Gonzalez, P. Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells. Investigative Ophthalmology and Visual Science. 2011;52:2999-3007. (2011) Abstract

Luna, C; Li, G; Qiu, J; Epstein, DL; Gonzalez, P. Cross-talk between miR-29 and transforming growth factor-betas in trabecular meshwork cells. Investigative Ophthalmology and Visual Science. 2011;52:3567-3572. (2011) Abstract

Luna, C; Li, G; Qiu, J; Epstein, DL; Gonzalez, P. MicroRNA-24 regulates the processing of latent TGFß1 during cyclic mechanical stress in human trabecular meshwork cells through direct targeting of FURIN. Journal of Cellular Physiology. 2011;226:1407-1414. (2011) Abstract

Inoue, T; Pattabiraman, PP; Epstein, DL; Vasantha Rao, P. Effects of chemical inhibition of N-WASP, a critical regulator of actin polymerization on aqueous humor outflow through the conventional pathway. Experimental Eye Research. 2010;90:360-367. (2010) Abstract

Inoue, T; Pecen, P; Maddala, R; Skiba, NP; Pattabiraman, PP; Epstein, DL; Rao, PV. Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells. Investigative Ophthalmology and Visual Science. 2010;51:6461-6471. (2010) Abstract

Khan, TT; Li, G; Navarro, ID; Kastury, RD; Zeil, CJ; Semchyshyn, TM; Moya, FJ; Epstein, DL; Gonzalez, P; Challa, P. LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma. Molecular Vision. 2010;16:2236-2241. (2010) Abstract

Li, G; Luna, C; Qiu, J; Epstein, DL; Gonzalez, P. Modulation of inflammatory markers by miR-146a during replicative senescence in trabecular meshwork cells. Investigative Ophthalmology and Visual Science. 2010;51:2976-2985. (2010) Abstract

Li, G; Luna, C; Qiu, J; Epstein, DL; Gonzalez, P. Targeting of integrin beta1 and kinesin 2alpha by microRNA 183. Journal of Biological Chemistry. 2010;285:5461-5471. (2010) Abstract

Lin, Y; Epstein, DL; Liton, PB. Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress. Investigative Ophthalmology and Visual Science. 2010;51:6483-6495. (2010) Abstract

Liton, PB; Gonzalez, P; Epstein, DL. The role of proteolytic cellular systems in trabecular meshwork homeostasis. Experimental Eye Research. 2009;88:724-728. (2009) Abstract

Liton, PB; Li, G; Luna, C; Gonzalez, P; Epstein, DL. Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells. Molecular Vision. 2009;15:326-334. (2009) Abstract

Liton, PB; Lin, Y; Gonzalez, P; Epstein, DL. Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma. Autophagy. 2009;5:122-124. (2009) Abstract

Luna, C; Li, G; Liton, PB; Qiu, J; Epstein, DL; Challa, P; Gonzalez, P. Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells. Food and Chemical Toxicology. 2009;47:198-204. (2009) Abstract

Liton, PB; Lin, Y; Luna, C; Li, G; Gonzalez, P; Epstein, DL. Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress. Investigative Ophthalmology and Visual Science. 2008;49:3961-3969. (2008) Abstract

Rao, VP; Epstein, DL. Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma. BioDrugs: clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2007;21:167-177. (2007) Abstract

Liton, PB; Luna, C; Challa, P; Epstein, DL; Gonzalez, P. Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue. Molecular Vision. 2006;12:774-790. (2006) Abstract

Liton, PB; Liu, X; Challa, P; Epstein, DL; Gonzalez, P. Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stress. Journal of Cellular Physiology. 2005;205:364-371. (2005) Abstract

Rao, PV; Shimazaki, A; Ichikawa, M; Franse-Carman, L; Alvarado, JA; Epstein, DL. Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow. Biological and Pharmaceutical Bulletin. 2005;28:2189-2196. (2005) Abstract

Caballero, M; Liton, PB; Challa, P; Epstein, DL; Gonzalez, P. Effects of donor age on proteasome activity and senescence in trabecular meshwork cells. Biochemical and Biophysical Research Communications. 2004;323:1048-1054. (2004) Abstract

Khurana, RN; Deng, PF; Epstein, DL; Vasantha Rao, P. The role of protein kinase C in modulation of aqueous humor outflow facility. Experimental Eye Research. 2003;76:39-47. (2003) Abstract

Rao, PV; Deng, PF; Kumar, J; Epstein, DL. Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. Investigative Ophthalmology and Visual Science. 2001;42:1029-1037. (2001) Abstract

Stamer, WD; Peppel, K; O'Donnell, ME; Roberts, BC; Wu, F; Epstein, DL. Expression of aquaporin-1 in human trabecular meshwork cells: role in resting cell volume. Investigative Ophthalmology and Visual Science. 2001;42:1803-1811. (2001) Abstract

Contact Us | Careers | Privacy Policy | Make a Gift | Site Map | RSS Feeds | En Español | Mobile Site | Help
Duke Medicine | Duke School of Medicine | Duke Children's | Duke University
Toll-Free: 888-ASK-DUKE (888-275-3853)
Copyright © 2004-2013 Duke University Health System

About This Page

Updated: Jan. 5, 2011
Published: Dec. 12, 2006
URL: http://www.dukehealth.org/physicians/david_l_epstein