Vice Chair, Faculty Affairs

Department / Division:
Surgery / Cardiovascular and Thoracic Surgery

Address:
DUMC 3627
Durham, NC 27710

Appointment Telephone:
919-668-8413

Office Telephone:
919-668-8413

Fax Telephone:
919-668-7157

• MD, University of Virginia School of Medicine, 1984

• General Surgery, Duke University Medical Center, 1984-1991

• Thoracic Surgery, Duke University Medical Center, 1991-1993
• Thoracic Oncology, Dana Farber Cancer Institute, Harvard Medical School (Massachusetts), 1993-1995

Clinical Interests:
Thoracic oncology; general thoracic surgery; benign and malignant disease of the lung, esophagus, and mediastinum; advanced airway and thoracoscopic surgery; hyperhidrosis palmaris; mesothelioma

Research Interests:
A.  Non-small cell lung cancer
1.  Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2.  Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3.  The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B.  Clinical research activities
1.  Creation of a prospective database for the Duke Thoracic Oncology Program.
2.  A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3.  Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures:  The VA Cooperative Surgical Risk Study
4.  A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Representative Publications:
Kinch MS, Moore MB, Harpole DH Jr. Predictive Value of the EphA2 Receptor Tyrosine Kinase in Lung Cancer Recurrence and Survival. Clin Cancer Res. 2003 Feb;9(2):613-8. (2003) Abstract

Joshi MB, D'Amico TA, Harpole DH Jr. Molecular biologic substaging of stage I NSCLC through immunohistochemistry performed on formalin-fixed, paraffin-embedded tissue. Methods Mol Med. 2003;75:369-88. (2003) Abstract

Bailey SH, Bull DA, Harpole DH, Rentz JJ, Neumayer LA, Pappas TN, Daley J, Henderson WG, Krasnicka B, Khuri SF. Outcomes after esophagectomy: a ten-year prospective cohort. Ann Thorac Surg. 2003 Jan;75(1):217-22; discussion 222. (2003) Abstract

Toloza EM, Harpole DH Jr. Intraoperative techniques to prevent air leaks. Chest Surg Clin N Am. 2002 Aug;12(3):489-505. (2002) Abstract

Lau CL, Moore MB, Brooks KR, D'Amico TA, Harpole DH Jr. Molecular staging of lung and esophageal cancer. Surg Clin North Am. 2002 Jun;82(3):497-523. (2002) Abstract

D'Amico TA, Wong TZ, Harpole DH, Brown SD, Coleman RE. Impact of computed tomography-positron emission tomography fusion in staging patients with thoracic malignancies. Ann Thorac Surg. 2002 Jul;74(1):160-3; discussion 163. (2002) Abstract

Marom EM, Aloia TA, Moore MB, Hara M, Herndon JE 2nd, Harpole DH Jr, Goodman PC, Patz EF Jr. Correlation of FDG-PET imaging with Glut-1 and Glut-3 expression in early-stage non-small cell lung cancer. Lung Cancer. 2001 Aug-Sep;33(2-3):99-107. (2001) Abstract

Kelley MJ, Li S, Harpole DH. Genetic analysis of the beta-tubulin gene, TUBB, in non-small-cell lung cancer. J Natl Cancer Inst. 2001 Dec 19;93(24):1886-8. (2001) Abstract

Harpole DH Jr, Moore MB, Herndon JE 2nd, Aloia T, D'Amico TA, Sporn T, Parr A, Linoila I, Allegra C. The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer. Clin Cancer Res. 2001 Mar;7(3):562-9. (2001) Abstract

D'Amico TA, Aloia TA, Moore MB, Conlon DH, Herndon JE 2nd, Kinch MS, Harpole DH Jr. Predicting the sites of metastases from lung cancer using molecular biologic markers. Ann Thorac Surg. 2001 Oct;72(4):1144-8. (2001) Abstract

Aloia TA, Harpole DH Jr, Reed CE, Allegra C, Moore MB, Herndon JE 2nd, D'Amico TA. Tumor marker expression is predictive of survival in patients with esophageal cancer. Ann Thorac Surg. 2001 Sep;72(3):859-66. (2001) Abstract

Harpole DH Jr, Gall SA, Rankin JS, Jones RH. Effects of valve replacement on ventricular mechanics in mitral regurgitation and aortic stenosis. Ann Thorac Surg 1996; 62:756-761. (1996)

Harpole DH Jr, Marks JR, Richards W, Sugarbaker DJ. Localized adenocarcinoma of the lung: oncogene expression of erbB-2 and p53 in 150 patients. Clin Cancer Res 1995; 1:659-664. (1995)

Harpole DH Jr, Herndon JE, Wolfe WG, Iglehart JD, Marks JR. A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression. Cancer Res, 1995; 55:51-56 (1995)

Harpole DH Jr, Rankin JS, Wolfe WG, Clements FM, VanTrigt P, Young WG, Jones RH. Effects of standard mitral valve replacement on left ventricular function. Ann Thorac Surg 1990; 49:866-74. (1990)