Department / Division:
Radiation Oncology / Radiation Oncology

Address:
DUMC 3085
Durham, NC 27710

Appointment Telephone:
919-613-5550

Office Telephone:
919-668-7339

Fax Telephone:
919-668-7345

• MD, Johns Hopkins University School of Medicine (Maryland), 2000

• Internal Medicine, Greater Baltimore Medical Center (Maryland), 2000-2001
• Radiation Oncology, Massachusetts General Hospital, 2001-2005

• PhD, Cellular and Molecular Medicine, Johns Hopkins School of Medicine (Maryland), 2000

Clinical Interests:
Bone and soft-tissue sarcomas

Research Interests:
My clinical interests are the multi-modality care of patients with bone and soft tissue sarcomas and developing new sarcoma therapies.  My laboratory interests include utilizing mouse models of cancer to study cancer and radiation biology in order to develop new cancer therapies in the pre-clinical setting.

Representative Publications:
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T. Restoration of p53 function leads to tumour regression in vivo. Nature. 2007 Feb 8;445(7128):661-5. (2007) Abstract

Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med. 2007 Sep;13(8):992-997. (2007) Abstract

Delaney TF, Kepka L, Goldberg SI, Hornicek FJ, Gebhardt MC, Yoon SS, Springfield DS, Raskin KA, Harmon DC, Kirsch DG, Mankin HJ, Rosenberg AE, Nielsen GP, Suit HD. Radiation therapy for control of soft-tissue sarcomas resected with positive margins. Int J Radiat Oncol Biol Phys. 2007 Apr 1;67(5):1460-9. (2007) Abstract

Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, Desphpande V, Suit HD, DeLaney TF, Yoon SS. Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol. 2007 Jun;14(6):1953-67. (2007) Abstract

Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R. Use of gene expression profiling to direct in vivo molecular imaging of lung cancer. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14404-9. (2005) Abstract

Kirsch DG, Doseff A, Chau BN, Lim DS, de Souza-Pinto NC, Hansford R, Kastan MB, Lazebnik YA, Hardwick JM. Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. J Biol Chem. 1999 Jul 23;274(30):21155-61. (1999) Abstract

Cheng EH, Kirsch DG, Clem RJ, Ravi R, Kastan MB, Bedi A, Ueno K, Hardwick JM. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science. 1997 Dec 12;278(5345):1966-8. (1997) Abstract

Kirsch DG, Hornicek FJ. Radiation Therapy for Soft-Tissue Sarcomas.  In Schwartz HS, editor. Orthopaedic Knowledge Update: Musculoskeletal Tumors ed 2 Rosemont, IL, American Association of Orthopaedic Surgeons. 2007, pp 313-320.

DeLaney TF, Rosenberg AE, Rosenberg, Harmon DC, Hornicek FJ, Yoon S, Kirsch DG, Mankin HJ, Rosenthal D, and Suit HD.  Soft tissue sarcomas.  In Price P, Sikora K, Illidge T. editors.  Arnold Publishing, UK. Treatment of Cancer (5th edition) 2007 in press.