Physicians

Departments / Divisions

• Radiation Oncology
• Pharmacology & Cancer Biology

Address
DUMC 3085
Durham, NC 27710

Appointment Telephone
919-613-5550 (Sarcoma),
919-660-2100 (Radiation oncology)

Office Telephone
919-668-7339

Fax Telephone
919-668-7345

Training

• MD, Johns Hopkins University School of Medicine (Maryland), 2000

Residency

• Internal Medicine, Greater Baltimore Medical Center (Maryland), 2000-2001
• Radiation Oncology, Massachusetts General Hospital, 2001-2005

Other Training

• PhD, Cellular and Molecular Medicine, Johns Hopkins School of Medicine (Maryland), 2000

Clinical Interests
Bone and soft-tissue sarcomas

Research Interests
My clinical interests are the multi-modality care of patients with bone and soft tissue sarcomas and developing new sarcoma therapies. My laboratory interests include utilizing mouse models of cancer to study cancer and radiation biology in order to develop new cancer therapies in the pre-clinical setting.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Lumicell Diagnostics Inc

Representative Publications
Eward, WC; Mito, JK; Eward, CA; Carter, JE; Ferrer, JM; Kirsch, DG; Brigman, BE. A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs. Clinical Orthopaedics and Related Research. 2013;471:834-842. (2013) Abstract

Mito, JK; Min, HD; Ma, Y; Carter, JE; Brigman, BE; Dodd, L; Dankort, D; McMahon, M; Kirsch, DG. Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma. Journal of Pathology. 2013;229:132-140. (2013) Abstract

Badea, CT; Athreya, KK; Espinosa, G; Clark, D; Ghafoori, AP; Li, Y; Kirsch, DG; Johnson, GA; Annapragada, A; Ghaghada, KB. Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent. PLoS One. 2012;7:e34496. (2012) Abstract

Belyea, B; Kephart, JG; Blum, J; Kirsch, DG; Linardic, CM. Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting. Sarcoma. 2012;2012:406239. (2012) Abstract

Cuneo, KC; Riedel, RF; Dodd, LG; Harpole, DH; Kirsch, DG. Pathologic complete response of a malignant peripheral nerve sheath tumor in the lung treated with neoadjuvant Ifosfamide and radiation therapy. Journal of Clinical Oncology. 2012;30:e291-e293. (2012) Abstract

Kim, S; Dodd, RD; Mito, JK; Ma, Y; Kim, Y; Riedel, RF; Kirsch, DG. Efficacy of phosphatidylinositol-3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcoma. Sarcoma. 2012;2012:680708. (2012) Abstract

Lee, CL; Moding, EJ; Cuneo, KC; Li, Y; Sullivan, JM; Mao, L; Washington, I; Jeffords, LB; Rodrigues, RC; Ma, Y; Das, S; Kontos, CD; Kim, Y; Rockman, HA; Kirsch, DG. p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice. Science Signaling. 2012;5:ra52. (2012) Abstract

Lee, CL; Moding, EJ; Huang, X; Li, Y; Woodlief, LZ; Rodrigues, RC; Ma, Y; Kirsch, DG. Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice. Disease Models and Mechanisms. 2012;5:397-402. (2012) Abstract

Mito, JK; Ferrer, JM; Brigman, BE; Lee, CL; Dodd, RD; Eward, WC; Marshall, LF; Cuneo, KC; Carter, JE; Ramasunder, S; Kim, Y; Lee, WD; Griffith, LG; Bawendi, MG; Kirsch, DG. Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging. Cancer. 2012;118:5320-5330. (2012) Abstract

Sullivan, JM; Jeffords, LB; Lee, CL; Rodrigues, R; Ma, Y; Kirsch, DG. p21 protects "Super p53" mice from the radiation-induced gastrointestinal syndrome. Radiation Research. 2012;177:307-310. (2012) Abstract

Kirsch, DG. Using genetically engineered mice for radiation research. Radiation Research. 2011;176:275-279. (2011) Abstract

Newton, J; Oldham, M; Thomas, A; Li, Y; Adamovics, J; Kirsch, DG; Das, S. Commissioning a small-field biological irradiator using point, 2D, and 3D dosimetry techniques. Medical Physics. 2011;38:6754-6762. (2011) Abstract

Wang, D; Bosch, W; Kirsch, DG; Al Lozi, R; El Naqa, I; Roberge, D; Finkelstein, SE; Petersen, I; Haddock, M; Chen, YL; Saito, NG; Hitchcock, YJ; Wolfson, AH; DeLaney, TF. Variation in the gross tumor volume and clinical target volume for preoperative radiotherapy of primary large high-grade soft tissue sarcoma of the extremity among RTOG sarcoma radiation oncologists. International Journal of Radiation: Oncology - Biology - Physics. 2011;81:e775-e780. (2011) Abstract

Wang, D; Bosch, W; Roberge, D; Finkelstein, SE; Petersen, I; Haddock, M; Chen, YL; Saito, NG; Kirsch, DG; Hitchcock, YJ; Wolfson, AH; DeLaney, TF. RTOG sarcoma radiation oncologists reach consensus on gross tumor volume and clinical target volume on computed tomographic images for preoperative radiotherapy of primary soft tissue sarcoma of extremity in Radiation Therapy Oncology Group studies. International Journal of Radiation: Oncology - Biology - Physics. 2011;81:e525-e528. (2011) Abstract

Weidhaas, JB; Kirsch, DG. The Holman Research Pathway in radiation oncology. International Journal of Radiation: Oncology - Biology - Physics. 2011;80:321-323. (2011) Abstract

Yoon, SS; Duda, DG; Karl, DL; Kim, TM; Kambadakone, AR; Chen, YL; Rothrock, C; Rosenberg, AE; Nielsen, GP; Kirsch, DG; Choy, E; Harmon, DC; Hornicek, FJ; Dreyfuss, J; Ancukiewicz, M; Sahani, DV; Park, PJ; Jain, RK; Delaney, TF. Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas. International Journal of Radiation: Oncology - Biology - Physics. 2011;81:1081-1090. (2011) Abstract

Curtis, SJ; Sinkevicius, KW; Li, D; Lau, AN; Roach, RR; Zamponi, R; Woolfenden, AE; Kirsch, DG; Wong, KK; Kim, CF. Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. Cell Stem Cell. 2010;7:127-133. (2010) Abstract

Dodd, RD; Mito, JK; Kirsch, DG. Animal models of soft-tissue sarcoma. Disease Models and Mechanisms. 2010;3:557-566. (2010) Abstract

Kim, B; Chen, YL; Kirsch, DG; Goldberg, SI; Kobayashi, W; Kung, JH; Wolfgang, JA; Doppke, K; Rosenberg, AE; Nielsen, GP; Raskin, KA; Springfield, DS; Schwab, JH; Gebhardt, MC; Yoon, SS; Hornicek, FJ; DeLaney, TF. An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control. International Journal of Radiation: Oncology - Biology - Physics. 2010;77:843-850. (2010) Abstract

Kirsch, DG; Grimm, J; Guimaraes, AR; Wojtkiewicz, GR; Perez, BA; Santiago, PM; Anthony, NK; Forbes, T; Doppke, K; Weissleder, R; Jacks, T. Imaging primary lung cancers in mice to study radiation biology. International Journal of Radiation: Oncology - Biology - Physics. 2010;76:973-977. (2010) Abstract

Kirsch, DG; Santiago, PM; di Tomaso, E; Sullivan, JM; Hou, WS; Dayton, T; Jeffords, LB; Sodha, P; Mercer, KL; Cohen, R; Takeuchi, O; Korsmeyer, SJ; Bronson, RT; Kim, CF; Haigis, KM; Jain, RK; Jacks, T. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science. 2010;327:593-596. (2010) Abstract

Williams, JP; Brown, SL; Georges, GE; Hauer-Jensen, M; Hill, RP; Huser, AK; Kirsch, DG; Macvittie, TJ; Mason, KA; Medhora, MM; Moulder, JE; Okunieff, P; Otterson, MF; Robbins, ME; Smathers, JB; McBride, WH. Animal models for medical countermeasures to radiation exposure. Radiation Research. 2010;173:557-578. (2010) Abstract

Yoon, SS; Chen, YL; Kirsch, DG; Maduekwe, UN; Rosenberg, AE; Nielsen, GP; Sahani, DV; Choy, E; Harmon, DC; DeLaney, TF. Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas. Annals of Surgical Oncology. 2010;17:1515-1529. (2010) Abstract

Kumar, MS; Pester, RE; Chen, CY; Lane, K; Chin, C; Lu, J; Kirsch, DG; Golub, TR; Jacks, T. Dicer1 functions as a haploinsufficient tumor suppressor. Genes and Development. 2009;23:2700-2704. (2009) Abstract

Mito, JK; Riedel, RF; Dodd, L; Lahat, G; Lazar, AJ; Dodd, RD; Stangenberg, L; Eward, WC; Hornicek, FJ; Yoon, SS; Brigman, BE; Jacks, T; Lev, D; Mukherjee, S; Kirsch, DG. Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. PLoS One. 2009;4:e8075. (2009) Abstract

Wagner, TD; Kobayashi, W; Dean, S; Goldberg, SI; Kirsch, DG; Suit, HD; Hornicek, FJ; Pedlow, FX; Raskin, KA; Springfield, DS; Yoon, SS; Gebhardt, MC; Mankin, HJ; Delaney, TF. Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the bone. International Journal of Radiation: Oncology - Biology - Physics. 2009;73:259-266. (2009) Abstract

Yoon, SS; Stangenberg, L; Lee, YJ; Rothrock, C; Dreyfuss, JM; Baek, KH; Waterman, PR; Nielsen, GP; Weissleder, R; Mahmood, U; Park, PJ; Jacks, T; Dodd, RD; Fisher, CJ; Ryeom, S; Kirsch, DG. Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. International Journal of Radiation: Oncology - Biology - Physics. 2009;74:1207-1216. (2009) Abstract

Lin, NU; Carey, LA; Liu, MC; Younger, J; Come, SE; Ewend, M; Harris, GJ; Bullitt, E; Van den Abbeele, AD; Henson, JW; Li, X; Gelman, R; Burstein, HJ; Kasparian, E; Kirsch, DG; Crawford, A; Hochberg, F; Winer, EP. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. Journal of Clinical Oncology. 2008;26:1993-1999. (2008) Abstract

Niedre, MJ; de Kleine, RH; Aikawa, E; Kirsch, DG; Weissleder, R; Ntziachristos, V. Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. Proceedings of the National Academy of Sciences of USA. 2008;105:19126-19131. (2008) Abstract

Abraham, JA; Hornicek, FJ; Kaufman, AM; Harmon, DC; Springfield, DS; Raskin, KA; Mankin, HJ; Kirsch, DG; Rosenberg, AE; Nielsen, GP; Desphpande, V; Suit, HD; DeLaney, TF; Yoon, SS. Treatment and outcome of 82 patients with angiosarcoma. Annals of Surgical Oncology. 2007;14:1953-1967. (2007) Abstract

Delaney, TF; Kepka, L; Goldberg, SI; Hornicek, FJ; Gebhardt, MC; Yoon, SS; Springfield, DS; Raskin, KA; Harmon, DC; Kirsch, DG; Mankin, HJ; Rosenberg, AE; Nielsen, GP; Suit, HD. Radiation therapy for control of soft-tissue sarcomas resected with positive margins. International Journal of Radiation: Oncology - Biology - Physics. 2007;67:1460-1469. (2007) Abstract

Kirsch, DG; Dinulescu, DM; Miller, JB; Grimm, J; Santiago, PM; Young, NP; Nielsen, GP; Quade, BJ; Chaber, CJ; Schultz, CP; Takeuchi, O; Bronson, RT; Crowley, D; Korsmeyer, SJ; Yoon, SS; Hornicek, FJ; Weissleder, R; Jacks, T. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nature Medicine. 2007;13:992-997. (2007) Abstract

Ventura, A; Kirsch, DG; McLaughlin, ME; Tuveson, DA; Grimm, J; Lintault, L; Newman, J; Reczek, EE; Weissleder, R; Jacks, T. Restoration of p53 function leads to tumour regression in vivo. Nature. 2007;445:661-665. (2007) Abstract

Kirsch, DG; Doseff, A; Chau, BN; Lim, DS; de Souza-Pinto, NC; Hansford, R; Kastan, MB; Lazebnik, YA; Hardwick, JM. Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. Journal of Biological Chemistry. 1999;274:21155-21161. (1999) Abstract

Cheng, EH; Kirsch, DG; Clem, RJ; Ravi, R; Kastan, MB; Bedi, A; Ueno, K; Hardwick, JM. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science. 1997;278:1966-1968. (1997) Abstract