Physicians

Department / Division
Anesthesiology / Anesthesiology-Regional Division

Address
DUMC 3094
Durham, NC 27710

Office Telephone
919-681-3551

Fax Telephone
919-681-8994

Training

• MB BS, Saint Mary's Hospital Medical School, University of London (United Kingdom), 1987

Residency

• Anesthesiology, Royal Naval Hospital, Portsmouth (United Kingdom), 1989-1996
• Specialist Registrar, Southampton University Hospitals (United Kingdom), 1996-1998

Fellowship

• Fellow, Royal College of Anaesthetists (United Kingdom), 1996

Clinical Interests
Regional and general anesthesiology; pulse oximetry; ultrasound; placement of central venous catheters, nerve blocks

Research Interests
Education and Regional Anesthesia
My principal clinical interest is the use of peripheral nerve blocks and the development of novel techniques to improve resident training. I have designed and launched a website (www.regionalABC.org) dedicated to lower extremity nerve blocks. This valuable resource is available to all clinicians in the operating room and in the pre-operative block area. It can be accessed by residents for learning and review whilst faculty can use the diagrams and clinical photographs to illustrate particular teaching points at the bedside. I am the co-director of the Carolina Cadaver Course, which is run annually in conjunction with Wake Forest University School of Medicine.
I am also actively involved in teaching the use of ultrasound for the placement of peripheral nerve blocks. I have lectured on several national courses.

Human Pharmacology Lab (HPL)
I am the Director of the HPL which is a Phase 1 research unit. The unit's members consist of clinical faculty with clinical interest across the spectrum of anesthesia. This year the HPL has completed the pharmacokinetic profile of a novel drug delivery device for inhaled fentanyl, which is currently under review by the FDA. We have started further volunteer and clinical studies of a new cerebral oximeter. The study group is about to embark upon a study to determine if dexmedetomidine confers the effect of restorative sleep upon postop surgical patients.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• CAS Medical Systems, Inc.

Representative Publications
Cortinez, LI; Somma, J; Robertson, KM; Keifer, JC; Wright, DR; Hsu, YW; MacLeod, DB; Moretti, EW. Changes in hematocrit based on incremental blood sampling: mathematical models perform poorly. Canadian Journal of Anaesthesia. 2005;52:374-378. (2005) Abstract

MacLeod, DB; Cortinez, LI; Keifer, JC; Cameron, D; Wright, DR; White, WD; Moretti, EW; Radulescu, LR; Somma, J. The desaturation response time of finger pulse oximeters during mild hypothermia. Anaesthesia. 2005;60:65-71. (2005) Abstract

Cortinez, LI; Hsu, YW; Sum-Ping, ST; Young, C; Keifer, JC; Macleod, D; Robertson, KM; Wright, DR; Moretti, EW; Somma, J. Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology. 2004;101:1077-1083. (2004) Abstract

Hsu, YW; Cortinez, LI; Robertson, KM; Keifer, JC; Sum-Ping, ST; Moretti, EW; Young, CC; Wright, DR; Macleod, DB; Somma, J. Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology. 2004;101:1066-1076. (2004) Abstract

Martin, G; Lineberger, CK; MacLeod, DB; El-Moalem, HE; Breslin, DS; Hardman, D; D'Ercole, F. A new teaching model for resident training in regional anesthesia. Anesthesia and Analgesia. 2002;95:1423-1427. (2002) Abstract