Department / Division:
Medicine / Cellular Therapy

Address:
DUMC 3961
Durham, NC 27710

Appointment Telephone:
919-668-1027

Office Telephone:
919-668-1040

Fax Telephone:
919-668-1091

• MD, University of Rochester School of Medicine and Dentistry (New York), 1991

• Internal Medicine, Strong Memorial Hospital, University of Rochester Medical Center (New York), 1991-1994

• Hematology and Oncology, Duke University Medical Center, 1994-1997

Clinical Interests:
Bone-marrow and stem-cell transplantation; manipulation of minimal residual disease in patients with hematologic malignancies (lymphoma, leukemia); phase 1 trials for leukemia and lymphoma

Research Interests:
My research interests focus on the care of patients with hematologic malignancies, both with and without the use of bone marrow or stem cell transplantation.  I focus my research efforts on new approaches to manipulate minimal residual disease.   Recent endeavors have included:
1) Phase one trials with novel anti-cancer agents targeting aurora kinases, tyrosine kinases, mtor, VEGF, and raf/ras pathways
2) New monoclonal antibodies targeting tumor stroma rather than cellular antigens
3) Investigating new antibody targets, i.e. CD123, endoglin, or tenascin for hematologic malignancies
4) Aggressive therapy and transplantation for mantle cell lymphoma
5) Antiangiogenesis therapy for patients with NHL
6) Nonablative allogeneic transplantation therapy with matched or mismatched donors followed by immune modulation

Representative Publications:
Shanks RH, Rizzieri DA, Flowers JL, Colvin OM, Adams DJ. Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia. Clin Cancer Res. 2005 Jun 1;11(11):4225-33. (2005) Abstract

Rao AV, Akabani G, Rizzieri DA. Radioimmunotherapy for Non-Hodgkin's Lymphoma. Clin Med Res. 2005 Aug;3(3):157-65. (2005) Abstract

Talbot J, Ibom VK, Rizzieri DA, Barrier R, Niedzwieki D, DeCastro CM, Moore JO, Buckley P, Laney R, Stevenson D, Rumbaugh H, Gockerman JP. Dose-intense cyclophosphamide and etoposide for patients with refractory or high-risk non-Hodgkin's lymphoma. Clin Lymphoma. 2004 Sep;5(2):116-22. (2004) Abstract

Snyder MJ, Stenzel TT, Buckley PJ, Lagoo AS, Rizzieri DA, Gasparetto C, Vredenburgh JJ, Chao NJ, Gong JZ. Posttransplant lymphoproliferative disorder following nonmyeloablative allogeneic stem cell transplantation. Am J Surg Pathol. 2004 Jun;28(6):794-800. (2004) Abstract

Rizzieri DA, Sand GJ, McGaughey D, Moore JO, DeCastro C, Chao NJ, Vredenburgh JJ, Gasparetto C, Long GD, Anderson E, Foster T, Toaso B, Adams D, Niedzwiecki D, Gockerman JP. Low-dose weekly paclitaxel for recurrent or refractory aggressive non-Hodgkin lymphoma. Cancer. 2004 Jun 1;100(11):2408-14. (2004) Abstract

Rizzieri DA, Johnson JL, Niedzwiecki D, Lee EJ, Vardiman JW, Powell BL, Barcos M, Bloomfield CD, Schiffer CA, Peterson BA, Canellos GP, Larson RA. Intensive chemotherapy with and without cranial radiation for Burkitt leukemia and lymphoma: final results of Cancer and Leukemia Group B Study 9251. Cancer. 2004 Apr 1;100(7):1438-48. (2004) Abstract

Rizzieri DA, Akabani G, Zalutsky MR, Coleman RE, Metzler SD, Bowsher JE, Toaso B, Anderson E, Lagoo A, Clayton S, Pegram CN, Moore JO, Gockerman JP, DeCastro C, Gasparetto C, Chao NJ, Bigner DD. Phase 1 trial study of 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphoma. Blood. 2004 Aug 1;104(3):642-8. (2004) Abstract

Chao NJ, Koh LP, Long GD, Gasparetto C, Horwitz M, Morris A, Lassiter M, Sullivan KM, Rizzieri DA. Adult recipients of umbilical cord blood transplants after nonmyeloablative preparative regimens. Biol Blood Marrow Transplant. 2004 Aug;10(8):569-75. (2004) Abstract

Bhagat R, Rizzieri DA, Vredenburgh JJ, Chao NJ, Folz RJ. Pulmonary sarcoidosis following stem cell transplantation: is it more than a chance occurrence? Chest. 2004 Aug;126(2):642-4. (2004) Abstract

Talbot J, Rizzieri DA, DeCastro CM, Moore JO, Buckley P, Laney R, Stevenson D, Brumbaugh H, Gockerman JP. High-dose cyclophosphamide and etoposide for patients with refractory acute myeloid leukemia: a case series. Am J Hematol. 2003 Aug;73(4):295-6. (2003) Abstract

Rizzieri DA, Talbot JT, Long GD, Vredenburgh JJ, Gasparetto C, Smith CS, Colvin MO, Adams D, Morris A, Dodge R, Loftis J, Waters-Pick B, Reese M, Carawan H, Koh LP, Chao NJ. 4-hydroperoxycyclophosphamide--purged peripheral blood stem cells for autologous transplantation in patients with acute myeloid leukemia. Biol Blood Marrow Transplant. 2003 Mar;9(3):183-8. (2003) Abstract

Rizzieri DA, Ibom VK, Moore JO, DeCastro CM, Rosner GL, Adams DJ, Foster T, Payne N, Thompson M, Vredenburgh JJ, Gasparetto C, Long GD, Chao NJ, Gockerman JP. Phase I evaluation of prolonged-infusion gemcitabine with fludarabine for relapsed or refractory acute myelogenous leukemia. Clin Cancer Res. 2003 Feb;9(2):663-8. (2003) Abstract

Ibom VK, Prosnitz RG, Gong JZ, Moore JO, DeCastro CM, Prosnitz LR, Rizzieri DA, Gockerman JP. Rituximab in lymphocyte predominance Hodgkin's disease: a case series. Clin Lymphoma. 2003 Sep;4(2):115-8. (2003) Abstract

Gong JZ, Stenzel TT, Bennett ER, Lagoo AS, Dunphy CH, Moore JO, Rizzieri DA, Tepperberg JH, Papenhausen P, Buckley PJ. Burkitt lymphoma arising in organ transplant recipients: a clinicopathologic study of five cases. Am J Surg Pathol. 2003 Jun;27(6):818-27. (2003) Abstract

Rizzieri DA, Bass AJ, Rosner GL, Gockerman JP, DeCastro CM, Petros WP, Adams DJ, Laughlin MJ, Davis P, Foster T, Jacobson R, Hurwitz H, Moore JO. Phase I evaluation of prolonged-infusion gemcitabine with mitoxantrone for relapsed or refractory acute leukemia. J Clin Oncol. 2002 Feb 1;20(3):674-9. (2002) Abstract

McCune SL, Gockerman JP, Moore JO, Decastro CM, Bass AJ, Chao NJ, Long GD, Vredenburgh JJ, Gasparetto C, Adams D, Payne N, Rizzieri DA. Alemtuzumab in relapsed or refractory chronic lymphocytic leukemia and prolymphocytic leukemia. Leuk Lymphoma. 2002 May;43(5):1007-11. (2002) Abstract

Gasparetto C, Gasparetto M, Morse M, Rooney B, Vredenburgh JJ, Long GD, Rizzieri DA, Loftis J, Chao NJ, Smith C. Mobilization of dendritic cells from patients with breast cancer into peripheral blood stem cell leukapheresis samples using Flt-3-Ligand and G-CSF or GM-CSF. Cytokine. 2002 Apr 7;18(1):8-19. (2002) Abstract

Chao NJ, Liu CX, Rooney B, Chen BJ, Long GD, Vredenburgh JJ, Morris A, Gasparetto C, Rizzieri DA. Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells. Biol Blood Marrow Transplant. 2002;8(5):249-56. (2002) Abstract

Bass AJ, Gong J, Nelson R, Rizzieri DA. CD52 expression in mantle cell lymphoma. Leuk Lymphoma. 2002 Feb;43(2):339-42. (2002) Abstract

Bass AJ, Gockerman JP, Hammett E, DeCastro CM, Adams DJ, Rosner GL, Payne N, Davis P, Foster T, Moore JO, Rizzieri DA. Phase I evaluation of prolonged-infusion gemcitabine with irinotecan for relapsed or refractory leukemia or lymphoma. J Clin Oncol. 2002 Jul 1;20(13):2995-3000. (2002) Abstract

Rizzieri DA, Long GD, Vredenburgh JJ, Gasparetto C, Morris A, Stenzel TT, Davis P, Chao NJ. Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen. Blood. 2001 Dec 1;98(12):3486-8. (2001) Abstract

McCune SL, Gockerman JP, Rizzieri DA. Monoclonal antibody therapy in the treatment of non-Hodgkin lymphoma. JAMA. 2001 Sep 12;286(10):1149-52. (2001) Abstract

Laughlin MJ, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE, Gerson SL, Lazarus HM, Cairo M, Stevens CE, Rubinstein P, Kurtzberg J. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med. 2001 Jun 14;344(24):1815-22. (2001) Abstract

Guzman ML, Upchurch D, Grimes B, Howard DS, Rizzieri DA, Luger SM, Phillips GL, Jordan CT. Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells. Blood. 2001 Apr 1;97(7):2177-9. (2001) Abstract

Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA, Luger SM, Jordan CT. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood. 2001 Oct 15;98(8):2301-7. (2001) Abstract

9. McCune S, Moore JO, Gockerman J, DeCastro C, Davis P, Bass A, Foster T, Rizzieri DA. Tolerance and efficacy of CAMPATH 1H for refractory CLL and PLL. Leukemia and lymphoma (accepted) 2001 (2001)

4. Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA, Luger SM, Jordan CT. Nuclear factor-kB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 98: 2301-2307, 2001 (2001)

3. McCune S, Gockerman J, Rizzieri DA. Monoclonal antibody therapy for non-Hodgkin's lymphoma. JAMA 286: 1149-1152, 2001 (2001)

Jordan CT, Upchurch D, Szilvassy SJ, Guzman ML, Howard DS, Pettigrew AL, Meyerrose T, Rossi R, Grimes B, Rizzieri DA, Luger SM, Phillips GL. The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia. 2000 Oct;14(10):1777-84. (2000) Abstract

Elconin JH, Roberts KB, Rizzieri DA, Vermont C, Clough RW, Kim C, Dodge RK, Prosnitz LR. Radiation dose selection in Hodgkin's disease patients with large mediastinal adenopathy treated with combined modality therapy. Int J Radiat Oncol Biol Phys. 2000 Nov 1;48(4):1097-105. (2000) Abstract

2. Rizzieri DA and Chao N. Immunosuppressive drug therapy for graft versus host disease prophylaxis in patients undergoing bone marrow or peripheral blood stem cell transplantation. Graft 2000 (2000)

1. Rizzieri DA, Long GD, Chao N. Acute Leukemia. Hospital Medicine, 1st edition, Ch 81, 2000. Eds. Wachter R, Goldman L, Hollander H. Williams and Wilkins. (2000)

Rizzieri DA, Vredenburgh JJ, Jones R, Ross M, Shpall EJ, Hussein A, Broadwater G, Berry D, Petros WP, Gilbert C, Affronti ML, Coniglio D, Rubin P, Elkordy M, Long GD, Chao NJ, Peters WP. Prognostic and predictive factors for patients with metastatic breast cancer undergoing aggressive induction therapy followed by high-dose chemotherapy with autologous stem-cell support. J Clin Oncol. 1999 Oct;17(10):3064-74. (1999) Abstract

Howard DS, Rizzieri DA, Grimes BA, Upchurch DT, Phillips GL, Stewart AK, Yannelli JR, Jordan CT. Genetic manipulation of primitive leukemic and normal hematopoietic cells using a movel method of adenovirus - mediated gene transfer. Leukemia 13:1608-1616, 1999 (1999)

Rizzieri DA, Chao N. Prevention and treatment of Graft versus Host Disease by pharmacological agents. Current Opinion in Organ Transplantation 3:105-111, 1998 (1998)

Laughlin MJ. Rizzieri DA. Smith CA. Moore JO. Lilly S. McGaughey D. Martin P. Carrier C. Stevens CE. Rubinstein P. Buckley R. Kurtzberg J. Hematologic engraftment and reconstitution of immune function post unrelated placental cord blood transplant in an adult with acute lymphocytic leukemia. Leukemia Research. 22:215-9, 1998 (1998)

Laughlin MJ, Rizzieri DA, Smith CA, Moore JO, Lilly S, McGaughey D, Martin P, Carrier C, Stevens CE, Rubinstein P, Buckley R, Kurtzberg J. Hematologic engraftment and reconstitution of immune function post unrelated placental cord blood transplant in an adult with acute lymphocytic leukemia. Leuk Res. 1998 Mar;22(3):215-9. (1998) Abstract

Rizzieri DA, Liu J, Traweek ST, Miralles GD. Clearance of HHV-8 from peripheral blood mononuclear cells with a protease inhibitor. Lancet. 1997 Mar 15;349(9054):775-6. (1997) Abstract

Rizzieri DA, Liu J, Miralles D, Traweek ST. Kaposi's-sarcoma-associated herpesvirus is detected in peripheral blood mononuclear cells of HIV-infected homosexuals more often than in heterosexuals. Cancer J Sci Am. 1997 May-Jun;3(3):153-6. (1997) Abstract

Rizzieri DA, Chao NJ. Treatment of non-Hodgkin's lymphoma with high-dose therapy and hematopoietic stem cell support. Curr Opin Oncol. 1997 Sep;9(5):420-7. (1997) Abstract

1. Rizzieri D, Chao N. Treatment of non-Hodgkin's lymphoma with high dose therapy and hematopoietic stem cell support. Current Opinion in Oncology 9: 420-427, 1997 (1997)

1. Rizzieri DA, Liu J, Miralles D, Traweek ST. KSHV is detected in PBMCs of HIV infected homosexuals more often than in heterosexuals. The Cancer Journal 3:153-156, 1997 (1997)

Rizzieri DA, Wong WM, Gockerman JP. Thrombocytosis associated with low-molecular-weight heparin. Ann Intern Med. 1996 Jul 15;125(2):157. (1996) Abstract

Rizzieri DA. Rhabdomyolysis after correction of hyponatremia due to psychogenic polydipsia. Mayo Clin Proc. 1995 May;70(5):473-6. (1995) Abstract