Department / Division
Medicine / Medicine-Infectious Diseases
Durham, NC 27710
Hospital-acquired infections, surgical wound and bone and joint infections, bloodstream and staphylococcal infections
During the past 8 years my research interests have changed from a focus on tick-borne disease and endocarditis to a primary focus on healthcare-associated infections (HAIs). Specifically, I have been interested in HAIs in community hospitals. Using prospective data collected as part of our surveillance activities in the Duke Infection Control Outreach Network (DICON), I and my colleagues have focused on these specific areas of research:
• The accuracy and reliability of surveillance definitions used to document and trend rates of HAIs
• Outcomes of HAIs (both financial and clinical) with particular emphasis on bloodstream and surgical site infections
• Trends in HAIs due to pathogens resistant to common antimicrobial agents
• Temporal and geographic variations in the occurrence of pathogens such as methicillin-resistant S. aureus, E coli and Klebsiella pneumonia
• The prevention and control of HAIs with particular emphasis on the potential role of the environment in the transmission of HAIs
As the principal investigator on one of the 5 national epicenter grants funded by the Centers for Disease control I, along with my co-investigators from the Duke and University of North Carolina Division of Infectious Disease, are involved in a 5-year prospective study of the potential benefit of enhanced cleaning methods (such as the use of ultraviolet light emitters) in the prevention of HAIs. This study involves 9 hospitals in North Carolina and Virginia and will include a trial of 4 different cleaning methods utilized sequentially but randomly in these study hospitals over a 28-month time period. Additionally the Duke Epicenter is also undertaking prospective trials investigating the utility and reliability of new (streamlined) definitions of ventilator-associated pneumonia.
Key words that characterize my work: surgical site infections and nosocomial infections.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
Anderson, DJ; Miller, BA; Chen, LF; Adcock, LH; Cook, E; Cromer, AL; Louis, S; Thacker, PA; Sexton, DJ. The network approach for prevention of healthcare-associated infections: long-term effect of participation in the Duke Infection Control Outreach Network. Infection Control and Hospital Epidemiology. 2011;32:315-322. (2011) Abstract
Miller, BA; Chen, LF; Sexton, DJ; Anderson, DJ. Comparison of the burdens of hospital-onset, healthcare facility-associated Clostridium difficile Infection and of healthcare-associated infection due to methicillin-resistant Staphylococcus aureus in community hospitals. Infection Control and Hospital Epidemiology. 2011;32:387-390. (2011) Abstract
Sexton, DJ; Miller, BA; Anderson, DJ. Measuring the effect of inappropriate initial antibiotic therapy on outcomes of patients with Gram-negative sepsis: An imprecise science. Critical Care Medicine. 2011;39:199-200. (2011) Abstract
Sexton, DJ; Chen, LF; Anderson, DJ. Current definitions of central line-associated bloodstream infection: is the emperor wearing clothes?. Infection Control and Hospital Epidemiology. 2010;31:1286-1289. (2010) Abstract
Freeman, JT; Sexton, DJ; Anderson, DJ. Emergence of extended-spectrum beta-lactamase-producing Escherichia coli in community hospitals throughout North Carolina: a harbinger of a wider problem in the United States?. Clinical Infectious Diseases. 2009;49:e30-e32. (2009) Abstract