Daniel Benjamin Jr., MD, PhD, MPH
Faculty Associate Director, Duke Clinical Research Institute
Department / Division
Pediatrics /
Pediatrics-Infectious Diseases
Address
Box 17969
Durham, NC 27715
Appointment Telephone
919-668-8980
Office Telephone
919-668-8980
Fax Telephone
919-681-9457
- MD, University of Virginia School of Medicine, 1995
- Pediatrics, University of Virginia Medical Center, 1998
- Infectious Disease, Duke University Medical Center, 2001
- MPH, University of North Carolina, 2001
- PhD, Epidemiology, University of North Carolina at Chapel Hill, 2003
Clinical Interests
Infections in neonates and bone-marrow transplant patients, meningitis, use of diagnostic tests
Research Interests
Neonatal Infectious Disease:
1) Neonatal candidiasis including diagnosis, prevention, and therapy
2) Antimicrobial therapeutics
Pediatric therapeutics:
1) Global drug development
2) PK-PD, dosing, and safety outcomes in children
3) Data transparency
This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
- Biosynexus, Inc.
- Cerexa (Forest Labs)
- Cubist Pharmaceuticals, Inc.
- GlaxoSmithKline
- Pfizer Inc.
Representative Publications
Cohen-Wolkowiez M, Benjamin DK Jr, Piper L, Cheifetz IM, Moran C, Liu P, Aram J, Kashuba AD, Capparelli E, Walsh TJ, Hope WW, Smith PB. Safety and pharmacokinetics of multiple-dose anidulafungin in infants and neonates. Clin Pharmacol Ther. 2011 May;89(5):702-7.
(2011)
Abstract
Greenberg RG, Benjamin DK Jr, Cohen-Wolkowiez M, Clark RH, Cotten CM, Laughon M, Smith PB. Repeat lumbar punctures in infants with meningitis in the neonatal intensive care unit. J Perinatol. 2011 Jun;31(6):425-9.
(2011)
Abstract
Jean-Baptiste N, Benjamin DK Jr, Cohen-Wolkowiez M, Fowler VG Jr, Laughon M, Clark RH, Smith PB. Coagulase-negative staphylococcal infections in the neonatal intensive care unit. Infect Control Hosp Epidemiol. 2011 Jul;32(7):679-86.
(2011)
Abstract
Piper L, Smith PB, Hornik CP, Cheifetz IM, Barrett JS, Moorthy G, Hope WW, Wade KC, Cohen-Wolkowiez M, Benjamin DK Jr. Fluconazole loading dose pharmacokinetics and safety in infants. Pediatr Infect Dis J. 2011 May;30(5):375-8.
(2011)
Abstract
Smith PB, Cohen-Wolkowiez M, Castro LM, Poindexter B, Bidegain M, Weitkamp JH, Schelonka RL, Ward RM, Wade K, Valencia G, Burchfield D, Arrieta A, Bhatt-Mehta V, Walsh M, Kantak A, Rasmussen M, Sullivan JE, Finer N, Brozanski BS, Sanchez P, van den Anker J, Blumer J, Kearns GL, Capparelli EV, Anand R, Benjamin DK Jr, . Population Pharmacokinetics of Meropenem in Plasma and Cerebrospinal Fluid of Infants With Suspected or Complicated Intra-abdominal Infections. Pediatr Infect Dis J. 2011 Aug 8.
(2011)
Abstract
Yanni SB, Smith PB, Benjamin DK Jr, Augustijns PF, Thakker DR, Annaert PP. Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding. Biopharm Drug Dispos. 2011 May;32(4):222-32.
(2011)
Abstract
Benjamin DK Jr, Smith PB, Arrieta A, Castro L, Sánchez PJ, Kaufman D, Arnold LJ, Kovanda LL, Sawamoto T, Buell DN, Hope WW, Walsh TJ. Safety and pharmacokinetics of repeat-dose micafungin in young infants. Clin Pharmacol Ther. 2010 Jan;87(1):93-9.
(2010)
Abstract
Benjamin DK Jr, Stoll BJ, Gantz MG, Walsh MC, Sánchez PJ, Das A, Shankaran S, Higgins RD, Auten KJ, Miller NA, Walsh TJ, Laptook AR, Carlo WA, Kennedy KA, Finer NN, Duara S, Schibler K, Chapman RL, Van Meurs KP, Frantz ID 3rd, Phelps DL, Poindexter BB, Bell EF, O'Shea TM, Watterberg KL, Goldberg RN, . Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. Pediatrics. 2010 Oct;126(4):e865-73.
(2010)
Abstract
Greenberg RG, Moran C, Ulshen M, Smith PB, Benjamin DK Jr, Cohen-Wolkowiez M. Outcomes of catheter-associated infections in pediatric patients with short bowel syndrome. J Pediatr Gastroenterol Nutr. 2010 Apr;50(4):460-2.
(2010)
Abstract
Hope WW, Smith PB, Arrieta A, Buell DN, Roy M, Kaibara A, Walsh TJ, Cohen-Wolkowiez M, Benjamin DK Jr. Population pharmacokinetics of micafungin in neonates and young infants. Antimicrob Agents Chemother. 2010 Jun;54(6):2633-7.
(2010)
Abstract
Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sánchez PJ, Ambalavanan N, Benjamin DK Jr, . Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009 Jan;123(1):58-66.
(2009)
Abstract
Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr, Calandra TF, Edwards JE Jr, Filler SG, Fisher JF, Kullberg BJ, Ostrosky-Zeichner L, Reboli AC, Rex JH, Walsh TJ, Sobel JD, . Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009 Mar 1;48(5):503-35.
(2009)
Abstract
Smith PB, Walsh TJ, Hope W, Arrieta A, Takada A, Kovanda LL, Kearns GL, Kaufman D, Sawamoto T, Buell DN, Benjamin DK Jr. Pharmacokinetics of an elevated dosage of micafungin in premature neonates. Pediatr Infect Dis J. 2009 May;28(5):412-5.
(2009)
Abstract
Wade KC, Benjamin DK Jr, Kaufman DA, Ward RM, Smith PB, Jayaraman B, Adamson PC, Gastonguay MR, Barrett JS. Fluconazole dosing for the prevention or treatment of invasive candidiasis in young infants. Pediatr Infect Dis J. 2009 Aug;28(8):717-23.
(2009)
Abstract
Benjamin DK Jr, Smith PB, Jadhav P, Gobburu JV, Murphy MD, Hasselblad V, Baker-Smith C, Califf RM, Li JS. Pediatric antihypertensive trial failures: analysis of end points and dose range. Hypertension. 2008 Apr;51(4):834-40.
(2008)
Abstract
Greenberg RG, Smith PB, Cotten CM, Moody MA, Clark RH, Benjamin DK Jr. Traumatic lumbar punctures in neonates: test performance of the cerebrospinal fluid white blood cell count. Pediatr Infect Dis J. 2008 Dec;27(12):1047-51.
(2008)
Abstract
Hope WW, Mickiene D, Petraitis V, Petraitiene R, Kelaher AM, Hughes JE, Cotton MP, Bacher J, Keirns JJ, Buell D, Heresi G, Benjamin DK Jr, Groll AH, Drusano GL, Walsh TJ. The pharmacokinetics and pharmacodynamics of micafungin in experimental hematogenous Candida meningoencephalitis: implications for echinocandin therapy in neonates. J Infect Dis. 2008 Jan 1;197(1):163-71.
(2008)
Abstract
Smith PB, Li JS, Murphy MD, Califf RM, Benjamin DK Jr. Safety of placebo controls in pediatric hypertension trials. Hypertension. 2008 Apr;51(4):829-33.
(2008)
Abstract
Wade KC, Wu D, Kaufman DA, Ward RM, Benjamin DK Jr, Sullivan JE, Ramey N, Jayaraman B, Hoppu K, Adamson PC, Gastonguay MR, Barrett JS, . Population pharmacokinetics of fluconazole in young infants. Antimicrob Agents Chemother. 2008 Nov;52(11):4043-9.
(2008)
Abstract
Cohen-Wolkowiez M, Benjamin DK Jr, Fowler VG Jr, Wade KC, Alexander BD, Worley G, Goldstein RF, Smith PB. Mortality and neurodevelopmental outcome after Staphylococcus aureus bacteremia in infants. Pediatr Infect Dis J. 2007 Dec;26(12):1159-61.
(2007)
Abstract
Cohen-Wolkowiez M, Smith PB, Mangum B, Steinbach WJ, Alexander BD, Cotten CM, Clark RH, Walsh TJ, Benjamin DK Jr. Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures. J Perinatol. 2007 Feb;27(2):97-100.
(2007)
Abstract
Lenfestey RW, Smith PB, Moody MA, Clark RH, Cotten CM, Seed PC, Benjamin DK Jr. Predictive value of cerebrospinal fluid parameters in neonates with intraventricular drainage devices. J Neurosurg. 2007 Sep;107(3 Suppl):209-12.
(2007)
Abstract
Li JS, Eisenstein EL, Grabowski HG, Reid ED, Mangum B, Schulman KA, Goldsmith JV, Murphy MD, Califf RM, Benjamin DK Jr. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA. 2007 Feb 7;297(5):480-8.
(2007)
Abstract
Benjamin DK Jr, Driscoll T, Seibel NL, Gonzalez CE, Roden MM, Kilaru R, Clark K, Dowell JA, Schranz J, Walsh TJ. Safety and pharmacokinetics of intravenous anidulafungin in children with neutropenia at high risk for invasive fungal infections. Antimicrob Agents Chemother. 2006 Feb;50(2):632-8.
(2006)
Abstract
Benjamin DK Jr, Smith PB, Murphy MD, Roberts R, Mathis L, Avant D, Califf RM, Li JS. Peer-reviewed publication of clinical trials completed for pediatric exclusivity. JAMA. 2006 Sep 13;296(10):1266-73.
(2006)
Abstract
Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, Duara S, Poole K, Laptook A, Goldberg R, . Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006 Jan;117(1):84-92.
(2006)
Abstract
Benjamin DK, Schelonka R, White R, Holley HP, Bifano E, Cummings J, Adcock K, Kaufman D, Puppala B, Riedel P, Hall B, White J, Cotton CM, . A blinded, randomized, multicenter study of an intravenous Staphylococcus aureus immune globulin. J Perinatol. 2006 May;26(5):290-5.
(2006)
Abstract
Cotten CM, McDonald S, Stoll B, Goldberg RN, Poole K, Benjamin DK Jr, . The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics. 2006 Aug;118(2):717-22.
(2006)
Abstract
Garges HP, Moody MA, Cotten CM, Smith PB, Tiffany KF, Lenfestey R, Li JS, Fowler VG Jr, Benjamin DK Jr. Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters? Pediatrics. 2006 Apr;117(4):1094-100.
(2006)
Abstract
Benjamin DK Jr, DeLong ER, Cotten CM, Garges HP, Clark RH. Postconception age and other risk factors associated with mortality following Gram-negative rod bacteremia. J Perinatol. 2004 Mar;24(3):169-74.
(2004)
Abstract
Benjamin DK, DeLong E, Cotten CM, Garges HP, Steinbach WJ, Clark RH. Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. J Perinatol. 2004 Mar;24(3):175-80.
(2004)
Abstract
Tiffany KF, Benjamin DK, Palasanthiran P, O'donnell K, Gutman LT. Improved Neurodevelopmental Outcomes following Long-Term High-Dose Oral Acyclovir Therapy in Infants with Central Nervous System and Disseminated Herpes Simplex Disease. J Perinatol. 2004 Dec 16.
(2004)
Abstract
