Daniel Benjamin Jr., MD, PhD, MPH

Department / Division:
Pediatrics / Infectious Diseases

Address:
Box 17969
Durham, NC 27715

Appointment Telephone:
919-668-7081

Office Telephone:
919-668-8295

Fax Telephone:
919-668-7058

• MD, University of Virginia School of Medicine, 1995

• Pediatrics, University of Virginia, 1998

• Infectious Disease, Duke University Medical Center, 2001

• MPH, University of North Carolina, 2001
• PhD, University of North Carolina at Chapel Hill, 2003

Clinical Interests:
Infections in the neonate, meningitis, infections in the bone marrow transplant patient, use of diagnostic tests

Research Interests:
Neonatal Infectious Disease:
1) Neonatal candidiasis including diagnosis, prevention, and therapy
3) Antibiotic and antifungal dosing in neonates, young infants, and children
3) Diagnosis of neonatal meningitis. This is a collaborative study with a large private practice group

Pediatric therapeutics:
1) Global drug development
2) PK-PD, dosing, and safety outcomes in children
3) Data transparency

Representative Publications:
Wade KC, Benjamin DK Jr, Kaufman DA, Ward RM, Smith PB, Jayaraman B, Adamson PC, Gastonguay MR, Barrett JS. Fluconazole dosing for the prevention or treatment of invasive candidiasis in young infants. Pediatr Infect Dis J. 2009 Aug;28(8):717-23. (2009) Abstract

Smith PB, Walsh TJ, Hope W, Arrieta A, Takada A, Kovanda LL, Kearns GL, Kaufman D, Sawamoto T, Buell DN, Benjamin DK Jr. Pharmacokinetics of an elevated dosage of micafungin in premature neonates. Pediatr Infect Dis J. 2009 May;28(5):412-5. (2009) Abstract

Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr, Calandra TF, Edwards JE Jr, Filler SG, Fisher JF, Kullberg BJ, Ostrosky-Zeichner L, Reboli AC, Rex JH, Walsh TJ, Sobel JD, . Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009 Mar 1;48(5):503-35. (2009) Abstract

Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sánchez PJ, Ambalavanan N, Benjamin DK Jr, . Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009 Jan;123(1):58-66. (2009) Abstract

Wade KC, Wu D, Kaufman DA, Ward RM, Benjamin DK Jr, Sullivan JE, Ramey N, Jayaraman B, Hoppu K, Adamson PC, Gastonguay MR, Barrett JS, . Population pharmacokinetics of fluconazole in young infants. Antimicrob Agents Chemother. 2008 Nov;52(11):4043-9. (2008) Abstract

Smith PB, Li JS, Murphy MD, Califf RM, Benjamin DK Jr. Safety of placebo controls in pediatric hypertension trials. Hypertension. 2008 Apr;51(4):829-33. (2008) Abstract

Smith PB, Garges HP, Cotton CM, Walsh TJ, Clark RH, Benjamin DK Jr. Meningitis in preterm neonates: importance of cerebrospinal fluid parameters. Am J Perinatol. 2008 Aug;25(7):421-6. (2008) Abstract

Hope WW, Mickiene D, Petraitis V, Petraitiene R, Kelaher AM, Hughes JE, Cotton MP, Bacher J, Keirns JJ, Buell D, Heresi G, Benjamin DK Jr, Groll AH, Drusano GL, Walsh TJ. The pharmacokinetics and pharmacodynamics of micafungin in experimental hematogenous Candida meningoencephalitis: implications for echinocandin therapy in neonates. J Infect Dis. 2008 Jan 1;197(1):163-71. (2008) Abstract

Greenberg RG, Smith PB, Cotten CM, Moody MA, Clark RH, Benjamin DK Jr. Traumatic lumbar punctures in neonates: test performance of the cerebrospinal fluid white blood cell count. Pediatr Infect Dis J. 2008 Dec;27(12):1047-51. (2008) Abstract

Cohen-Wolkowiez M, Smith PB, Benjamin DK Jr, Fowler VG Jr, Wade KC. Daptomycin use in infants: report of two cases with peak and trough drug concentrations. J Perinatol. 2008 Mar;28(3):233-4. (2008) Abstract

Benjamin DK Jr, Smith PB, Jadhav P, Gobburu JV, Murphy MD, Hasselblad V, Baker-Smith C, Califf RM, Li JS. Pediatric antihypertensive trial failures: analysis of end points and dose range. Hypertension. 2008 Apr;51(4):834-40. (2008) Abstract

Baddley JW, Benjamin DK Jr, Patel M, Miró J, Athan E, Barsic B, Bouza E, Clara L, Elliott T, Kanafani Z, Klein J, Lerakis S, Levine D, Spelman D, Rubinstein E, Tornos P, Morris AJ, Pappas P, Fowler VG Jr, Chu VH, Cabell C, . Candida infective endocarditis. Eur J Clin Microbiol Infect Dis. 2008 Feb 19. (2008) Abstract

Smith PB, Steinbach WJ, Cotten CM, Schell WA, Perfect JR, Walsh TJ, Benjamin DK Jr. Caspofungin for the treatment of azole resistant candidemia in a premature infant. J Perinatol. 2007 Feb;27(2):127-9. (2007) Abstract

Smith PB, Morgan J, Benjamin JD, Fridkin SK, Sanza LT, Harrison LH, Sofair AN, Huie-White S, Benjamin DK Jr. Excess costs of hospital care associated with neonatal candidemia. Pediatr Infect Dis J. 2007 Mar;26(3):197-200. (2007) Abstract

Li JS, Eisenstein EL, Grabowski HG, Reid ED, Mangum B, Schulman KA, Goldsmith JV, Murphy MD, Califf RM, Benjamin DK Jr. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA. 2007 Feb 7;297(5):480-8. (2007) Abstract

Lenfestey RW, Smith PB, Moody MA, Clark RH, Cotten CM, Seed PC, Benjamin DK Jr. Predictive value of cerebrospinal fluid parameters in neonates with intraventricular drainage devices. J Neurosurg. 2007 Sep;107(3 Suppl):209-12. (2007) Abstract

Cohen-Wolkowiez M, Smith PB, Mangum B, Steinbach WJ, Alexander BD, Cotten CM, Clark RH, Walsh TJ, Benjamin DK Jr. Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures. J Perinatol. 2007 Feb;27(2):97-100. (2007) Abstract

Cohen-Wolkowiez M, Benjamin DK Jr, Fowler VG Jr, Wade KC, Alexander BD, Worley G, Goldstein RF, Smith PB. Mortality and neurodevelopmental outcome after Staphylococcus aureus bacteremia in infants. Pediatr Infect Dis J. 2007 Dec;26(12):1159-61. (2007) Abstract

Garges HP, Moody MA, Cotten CM, Smith PB, Tiffany KF, Lenfestey R, Li JS, Fowler VG Jr, Benjamin DK Jr. Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters? Pediatrics. 2006 Apr;117(4):1094-100. (2006) Abstract

Cotten CM, McDonald S, Stoll B, Goldberg RN, Poole K, Benjamin DK Jr, . The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics. 2006 Aug;118(2):717-22. (2006) Abstract

Benjamin DK, Schelonka R, White R, Holley HP, Bifano E, Cummings J, Adcock K, Kaufman D, Puppala B, Riedel P, Hall B, White J, Cotton CM, . A blinded, randomized, multicenter study of an intravenous Staphylococcus aureus immune globulin. J Perinatol. 2006 May;26(5):290-5. (2006) Abstract

Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, Duara S, Poole K, Laptook A, Goldberg R, . Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006 Jan;117(1):84-92. (2006) Abstract

Benjamin DK Jr, Smith PB, Murphy MD, Roberts R, Mathis L, Avant D, Califf RM, Li JS. Peer-reviewed publication of clinical trials completed for pediatric exclusivity. JAMA. 2006 Sep 13;296(10):1266-73. (2006) Abstract

Benjamin DK Jr, Driscoll T, Seibel NL, Gonzalez CE, Roden MM, Kilaru R, Clark K, Dowell JA, Schranz J, Walsh TJ. Safety and pharmacokinetics of intravenous anidulafungin in children with neutropenia at high risk for invasive fungal infections. Antimicrob Agents Chemother. 2006 Feb;50(2):632-8. (2006) Abstract

Tiffany KF, Benjamin DK, Palasanthiran P, O'donnell K, Gutman LT. Improved Neurodevelopmental Outcomes following Long-Term High-Dose Oral Acyclovir Therapy in Infants with Central Nervous System and Disseminated Herpes Simplex Disease. J Perinatol. 2004 Dec 16. (2004) Abstract

Benjamin DK, DeLong E, Cotten CM, Garges HP, Steinbach WJ, Clark RH. Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. J Perinatol. 2004 Mar;24(3):175-80. (2004) Abstract

Benjamin DK Jr, DeLong ER, Cotten CM, Garges HP, Clark RH. Postconception age and other risk factors associated with mortality following Gram-negative rod bacteremia. J Perinatol. 2004 Mar;24(3):169-74. (2004) Abstract

Benjamin DK Jr, Poole C, Steinbach WJ, Rowen JL, Walsh TJ. Neonatal candidemia and end-organ damage: a critical appraisal of the literature using meta-analytic techniques. Pediatrics. 2003 Sep;112(3 Pt 1):634-40. (2003) Abstract

Benjamin DK Jr, DeLong ER, Steinbach WJ, Cotton CM, Walsh TJ, Clark RH. Empirical therapy for neonatal candidemia in very low birth weight infants. Pediatrics. 2003 Sep;112(3 Pt 1):543-7. (2003) Abstract

Benjamin DK Jr, Miller W, Garges H, Benjamin DK, McKinney RE Jr, Cotton M, Fisher RG, Alexander KA. Bacteremia, central catheters, and neonates: when to pull the line. Pediatrics. 2001 Jun;107(6):1272-6. (2001) Abstract

Benjamin DK Jr, Ross K, McKinney RE Jr, Benjamin DK, Auten R, Fisher RG. When to suspect fungal infection in neonates: A clinical comparison of Candida albicans and Candida parapsilosis fungemia with coagulase-negative staphylococcal bacteremia. Pediatrics. 2000 Oct;106(4):712-8. (2000) Abstract