Physicians

Faculty Associate Director, Duke Clinical Research Institute

Department / Division
Pediatrics / Pediatrics-Infectious Diseases

Address
Box 17969
Durham, NC 27715

Appointment Telephone
919-668-7081

Office Telephone
919-668-7081

Fax Telephone
919-681-9457

Training

• MD, University of Virginia School of Medicine, 1995

Residency

• Pediatrics, University of Virginia Medical Center, 1998

Fellowship

• Infectious Disease, Duke University Medical Center, 2001

Other Training

• MPH, University of North Carolina, 2001
• PhD, Epidemiology, University of North Carolina–Chapel Hill, 2003

Clinical Interests
Infections in neonates and bone-marrow transplant patients, meningitis, use of diagnostic tests

Research Interests
Neonatal Infectious Disease:
1) Neonatal candidiasis including diagnosis, prevention, and therapy
2) Antimicrobial therapeutics

Pediatric therapeutics:
1) Global drug development
2) PK-PD, dosing, and safety outcomes in children
3) Data transparency

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Astellas Pharma Inc.
• Cempra Pharmaceuticals
• Centocor, Inc. (Johnson & Johnson)
• Cerexa (Forest Labs)
• Cubist Pharmaceuticals, Inc.
• Medicines Company
• Merck & Co. USA (not assoc'd with Merck KGaA)
• Pfizer Inc.

Representative Publications
Cohen-Wolkowiez, M; Benjamin, DK; Piper, L; Cheifetz, IM; Moran, C; Liu, P; Aram, J; Kashuba, AD; Capparelli, E; Walsh, TJ; Hope, WW; Smith, PB. Safety and pharmacokinetics of multiple-dose anidulafungin in infants and neonates. Clinical Pharmacology and Therapeutics. 2011;89:702-707. (2011) Abstract

Greenberg, RG; Benjamin, DK; Cohen-Wolkowiez, M; Clark, RH; Cotten, CM; Laughon, M; Smith, PB. Repeat lumbar punctures in infants with meningitis in the neonatal intensive care unit. Journal of Perinatology. 2011;31:425-429. (2011) Abstract

Jean-Baptiste, N; Benjamin, DK; Cohen-Wolkowiez, M; Fowler, VG; Laughon, M; Clark, RH; Smith, PB. Coagulase-negative staphylococcal infections in the neonatal intensive care unit. Infection Control and Hospital Epidemiology. 2011;32:679-686. (2011) Abstract

Piper, L; Smith, PB; Hornik, CP; Cheifetz, IM; Barrett, JS; Moorthy, G; Hope, WW; Wade, KC; Cohen-Wolkowiez, M; Benjamin, DK. Fluconazole loading dose pharmacokinetics and safety in infants. Pediatric Infectious Disease Journal. 2011;30:375-378. (2011) Abstract

Smith, PB; Cohen-Wolkowiez, M; Castro, LM; Poindexter, B; Bidegain, M; Weitkamp, JH; Schelonka, RL; Ward, RM; Wade, K; Valencia, G; Burchfield, D; Arrieta, A; Bhatt-Mehta, V; Walsh, M; Kantak, A; Rasmussen, M; Sullivan, JE; Finer, N; Brozanski, BS; Sanchez, P; van den Anker, J; Blumer, J; Kearns, GL; Capparelli, EV; Anand, R; Benjamin, DK; Meropenem Study Team. Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections. Pediatric Infectious Disease Journal. 2011;30:844-849. (2011) Abstract

Yanni, SB; Smith, PB; Benjamin, DK; Augustijns, PF; Thakker, DR; Annaert, PP. Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding. Biopharmaceutics and Drug Disposition. 2011;32:222-232. (2011) Abstract

Benjamin, DK; Smith, PB; Arrieta, A; Castro, L; Sánchez, PJ; Kaufman, D; Arnold, LJ; Kovanda, LL; Sawamoto, T; Buell, DN; Hope, WW; Walsh, TJ. Safety and pharmacokinetics of repeat-dose micafungin in young infants. Clinical Pharmacology and Therapeutics. 2010;87:93-99. (2010) Abstract

Benjamin, DK; Stoll, BJ; Gantz, MG; Walsh, MC; Sánchez, PJ; Das, A; Shankaran, S; Higgins, RD; Auten, KJ; Miller, NA; Walsh, TJ; Laptook, AR; Carlo, WA; Kennedy, KA; Finer, NN; Duara, S; Schibler, K; Chapman, RL; Van Meurs, KP; Frantz, ID; Phelps, DL; Poindexter, BB; Bell, EF; O'Shea, TM; Watterberg, KL; Goldberg, RN; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. Pediatrics. 2010;126:e865-e873. (2010) Abstract

Greenberg, RG; Moran, C; Ulshen, M; Smith, PB; Benjamin, DK; Cohen-Wolkowiez, M. Outcomes of catheter-associated infections in pediatric patients with short bowel syndrome. Journal of Pediatric Gastroenterology and Nutrition. 2010;50:460-462. (2010) Abstract

Hope, WW; Smith, PB; Arrieta, A; Buell, DN; Roy, M; Kaibara, A; Walsh, TJ; Cohen-Wolkowiez, M; Benjamin, DK. Population pharmacokinetics of micafungin in neonates and young infants. Antimicrobial Agents and Chemotherapy. 2010;54:2633-2637. (2010) Abstract

Cotten, CM; Taylor, S; Stoll, B; Goldberg, RN; Hansen, NI; Sánchez, PJ; Ambalavanan, N; Benjamin, DK; NICHD Neonatal Research Network. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009;123:58-66. (2009) Abstract

Pappas, PG; Kauffman, CA; Andes, D; Benjamin, DK; Calandra, TF; Edwards, JE; Filler, SG; Fisher, JF; Kullberg, BJ; Ostrosky-Zeichner, L; Reboli, AC; Rex, JH; Walsh, TJ; Sobel, JD; Infectious Diseases Society of America. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clinical Infectious Diseases. 2009;48:503-535. (2009) Abstract

Smith, PB; Walsh, TJ; Hope, W; Arrieta, A; Takada, A; Kovanda, LL; Kearns, GL; Kaufman, D; Sawamoto, T; Buell, DN; Benjamin, DK. Pharmacokinetics of an elevated dosage of micafungin in premature neonates. Pediatric Infectious Disease Journal. 2009;28:412-415. (2009) Abstract

Wade, KC; Benjamin, DK; Kaufman, DA; Ward, RM; Smith, PB; Jayaraman, B; Adamson, PC; Gastonguay, MR; Barrett, JS. Fluconazole dosing for the prevention or treatment of invasive candidiasis in young infants. Pediatric Infectious Disease Journal. 2009;28:717-723. (2009) Abstract

Benjamin, DK; Smith, PB; Jadhav, P; Gobburu, JV; Murphy, MD; Hasselblad, V; Baker-Smith, C; Califf, RM; Li, JS. Pediatric antihypertensive trial failures: analysis of end points and dose range. Hypertension. 2008;51:834-840. (2008) Abstract

Greenberg, RG; Smith, PB; Cotten, CM; Moody, MA; Clark, RH; Benjamin, DK. Traumatic lumbar punctures in neonates: test performance of the cerebrospinal fluid white blood cell count. Pediatric Infectious Disease Journal. 2008;27:1047-1051. (2008) Abstract

Hope, WW; Mickiene, D; Petraitis, V; Petraitiene, R; Kelaher, AM; Hughes, JE; Cotton, MP; Bacher, J; Keirns, JJ; Buell, D; Heresi, G; Benjamin, DK; Groll, AH; Drusano, GL; Walsh, TJ. The pharmacokinetics and pharmacodynamics of micafungin in experimental hematogenous Candida meningoencephalitis: implications for echinocandin therapy in neonates. Journal of Infectious Diseases. 2008;197:163-171. (2008) Abstract

Smith, PB; Li, JS; Murphy, MD; Califf, RM; Benjamin, DK. Safety of placebo controls in pediatric hypertension trials. Hypertension. 2008;51:829-833. (2008) Abstract

Wade, KC; Wu, D; Kaufman, DA; Ward, RM; Benjamin, DK; Sullivan, JE; Ramey, N; Jayaraman, B; Hoppu, K; Adamson, PC; Gastonguay, MR; Barrett, JS; National Institute of Child Health and Development Pediatric Pharmacology Research Unit Network. Population pharmacokinetics of fluconazole in young infants. Antimicrobial Agents and Chemotherapy. 2008;52:4043-4049. (2008) Abstract

Cohen-Wolkowiez, M; Benjamin, DK; Fowler, VG; Wade, KC; Alexander, BD; Worley, G; Goldstein, RF; Smith, PB. Mortality and neurodevelopmental outcome after Staphylococcus aureus bacteremia in infants. Pediatric Infectious Disease Journal. 2007;26:1159-1161. (2007) Abstract

Cohen-Wolkowiez, M; Smith, PB; Mangum, B; Steinbach, WJ; Alexander, BD; Cotten, CM; Clark, RH; Walsh, TJ; Benjamin, DK. Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures. Journal of Perinatology. 2007;27:97-100. (2007) Abstract

Lenfestey, RW; Smith, PB; Moody, MA; Clark, RH; Cotten, CM; Seed, PC; Benjamin, DK. Predictive value of cerebrospinal fluid parameters in neonates with intraventricular drainage devices. Journal of Neurosurgery. 2007;107:209-212. (2007) Abstract

Li, JS; Eisenstein, EL; Grabowski, HG; Reid, ED; Mangum, B; Schulman, KA; Goldsmith, JV; Murphy, MD; Califf, RM; Benjamin, DK. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA: Journal of the American Medical Association. 2007;297:480-488. (2007) Abstract

Benjamin, DK; Driscoll, T; Seibel, NL; Gonzalez, CE; Roden, MM; Kilaru, R; Clark, K; Dowell, JA; Schranz, J; Walsh, TJ. Safety and pharmacokinetics of intravenous anidulafungin in children with neutropenia at high risk for invasive fungal infections. Antimicrobial Agents and Chemotherapy. 2006;50:632-638. (2006) Abstract

Benjamin, DK; Schelonka, R; White, R; Holley, HP; Bifano, E; Cummings, J; Adcock, K; Kaufman, D; Puppala, B; Riedel, P; Hall, B; White, J; Cotton, CM; S. aureus prevention investigators. A blinded, randomized, multicenter study of an intravenous Staphylococcus aureus immune globulin. Journal of Perinatology. 2006;26:290-295. (2006) Abstract

Benjamin, DK; Smith, PB; Murphy, MD; Roberts, R; Mathis, L; Avant, D; Califf, RM; Li, JS. Peer-reviewed publication of clinical trials completed for pediatric exclusivity. JAMA: Journal of the American Medical Association. 2006;296:1266-1273. (2006) Abstract

Benjamin, DK; Stoll, BJ; Fanaroff, AA; McDonald, SA; Oh, W; Higgins, RD; Duara, S; Poole, K; Laptook, A; Goldberg, R; National Institute of Child Health and Human Development Neonatal Research Network. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006;117:84-92. (2006) Abstract

Cotten, CM; McDonald, S; Stoll, B; Goldberg, RN; Poole, K; Benjamin, DK; National Institute for Child Health and Human Development Neonatal Research Network. The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics. 2006;118:717-722. (2006) Abstract

Garges, HP; Moody, MA; Cotten, CM; Smith, PB; Tiffany, KF; Lenfestey, R; Li, JS; Fowler, VG; Benjamin, DK. Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters?. Pediatrics. 2006;117:1094-1100. (2006) Abstract

Tiffany, KF; Benjamin, DK; Palasanthiran, P; O'Donnell, K; Gutman, LT. Improved neurodevelopmental outcomes following long-term high-dose oral acyclovir therapy in infants with central nervous system and disseminated herpes simplex disease. Journal of Perinatology. 2005;25:156-161. (2005) Abstract

Benjamin, DK; DeLong, E; Cotten, CM; Garges, HP; Steinbach, WJ; Clark, RH. Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. Journal of Perinatology. 2004;24:175-180. (2004) Abstract

Benjamin, DK; DeLong, ER; Cotten, CM; Garges, HP; Clark, RH. Postconception age and other risk factors associated with mortality following Gram-negative rod bacteremia. Journal of Perinatology. 2004;24:169-174. (2004) Abstract