Physicians

Department / Division
Medicine / Medicine - Cardiology

Address
DUMC 3485
Durham, NC 27710

Appointment Telephone
919-681-5816

Office Telephone
919-668-8775

Fax Telephone
919-668-7060

Training

• MD, Tufts University School of Medicine (Massachusetts), 1978

Residency

• Internal Medicine, University of Virginia Hospital, 1980-1982
• Cardiology, Duke University Medical Center, 1982-1985

Other Training

• MPH, Harvard School of Public Health (Massachusetts), 1979

Clinical Interests
Intensive cardiac care, acute myocardial infarction and unstable angina, consultative cardiology

Research Interests
Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center.  He is also the Director of Outcomes Research at the Duke Clinical Research Institute.  He has been on the full-time faculty at Duke since 1985.  Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard.  In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians.  These organizations are the two most prestigious honor societies in academic medicine.  In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care.  Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH).  He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline.  He is also the Editor of the American Heart Journal.  Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters.  He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Industry Relationships and Collaborations (What's this?)

This physician has no reported relationships with industry.

Representative Publications
Mark DB, Harrington RA, Lincoff AM, Califf RM, Nelson CL, Tsiatis AA, Buell HE, Mahaffey KW, Davidson-Ray L, Topol EJ. Cost effectiveness of platelet glycoprotein IIb/IIIa inhibition with eptifibatide in patients with Non-ST elevation acute coronary syndromes. Circulation 2000;101(4):366-371. (2000)

Braunwald E, Mark DB, Jones RH, Cheitlin MD, Fuster V, McCauley KM, Edwards C, Green LA, Mushlin AI, Swain JA, Smith EE, Cowan M, Rose GC, Concannon CA, Grines CL, Brown L, Lytle BW, Goldman L, Topol EJ, Willerson JT, Brown J, Archibald N. Diagnosing and managing unstable angina. Clinical Practice Guideline Number X. AHCPR Publication No. 97-N010. December 1996. (1996)

Mark DB, Hlatky MA, Califf RM, Naylor CD, Lee KL, Armstrong P, Barbash G, White H, Simoons ML, Nelson CL, Clapp-Channing N, Knight JD, Harrell FE Jr., Simes J, Topol EJ. Cost effectiveness of thrombolytic therapy with tissue plasminogen activator as compared with streptokinase for acute myocardial infarction. N Engl J Med 1995;332(21):1418-1424. (1995)

Mark DB, Naylor CD, Hlatky MA, Califf RM, Topol EJ, Granger CB, Knight JD, Nelson CL, Lee KL, Clapp-Channing N, Sutherland W, Pilote L, Armstrong PW. Use of medical resources and quality of life outcomes after acute myocardial infarction in Canada versus the United States. N Engl J Med 1994;331(17):1130-1135. (1994)

Mark DB, Shaw L, Harrell FE Jr., Hlatky MA, Lee KL, Bengtson JR, McCants CB, Califf RM, Pryor DB. Prognostic value of a treadmill exercise score in outpatients with suspected coronary artery disease. N Engl J Med 1991;325:849-53. (1991)