Physicians

Department / Division
Surgery / Urology

Address
DUMC 3274
Durham, NC 27710

Appointment Telephone
919-684-2127

Office Telephone
919-684-2127

Fax Telephone
919-681-7423

Training

• MD, Temple University School of Medicine (Pennsylvania), 1979

Residency

• Surgery, U.S. Public Health Service Hospital (California), 1979-1986
• Urology, Letterman Army Medical Center, Presidio of San Francisco (California), 1981-1985
• University of California, San Francisco, 1990-1991

Clinical Interests
Erectile dysfunction, male sexual dysfunction, infertility, vasectomies and reversal of vasectomies, prostate enlargement, prostate brachytherapy for prostate cancer

Research Interests
Erectile dysfunction:
BASIC:
*nonadrenergic-noncholinergic neurotransmission and neuropathy
*hyperlipidemia and endothelial relaxation in erection
*vascular endothelial growth factor, its role in erection and potential for  therapeutic action
*tunica vaginalis versus saphenous vein circumferential grafting of the corpora cavernosa, and animal model of Peyronie's Disease
APPLIED:
*clinical trial of sildenafil for the treatment of men with erectile dysfunction and depression
*alternative delivery systems for vasoactive drugs used in a pharmacologic erection program
*the effect of focused psychological intervention on long-term compliance rates with minimally invasive therapies of erectile dysfunction
*incidence of sexual dysfunction in male heart transplant patients

Benign Prostatic Hyperplasia:
BASIC:
alpha adrenergic nervous system in the pathogenesis of BPH
APPLIED:
Minimally invasive therapy outcomes in the treatment of benign prostatic hyperplasia

Industry Relationships and Collaborations (What's this?)

This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Abbott Laboratories
• American Medical Systems
• Auxilium Pharmaceuticals, Inc.
• Coloplast Corp
• Eli Lilly & Co.
• Endo Pharmaceuticals
• Pfizer Inc.
• Shionogi Pharma

Representative Publications
Dahm P, Rao DS, Donatucci CF. Antiandrogens in the treatment of priapism. Urology. 2002 Jan;59(1):138. (2002) Abstract

Byrne RR, Henry GD, Rao DS, Huynh TT, Pippen AM, Annex BH, Hagen PO, Donatucci CF. Vascular endothelial growth factor restores corporeal smooth muscle function in vitro. J Urol. 2001 Apr;165(4):1310-5. (2001) Abstract

Byrne RR, Henry GD, Rao DS, Huynh TTT, Pippen AM, Annex BH, Hagen PO, Donatucci CF. Vascular Endothelial Growth Factor Restores Corporeal Smooth Muscle Function In Vitro. Journal of Urology. 165(4):1310-1315, April 2001. (2001)

Rao DS, Donatucci CF. Vasculogenic impotence. Arterial and venous surgery. Urol Clin North Am. 2001 May;28(2):309-19. (2001) Abstract

Bladder neck hypertrophy. In: The 5 Minute Urology Consult. Edited by: L.G. Gomella, Lippincott Williams & Wilkins, Baltimore, MD, 86-89, 2000. (2000)

Donatucci CF. Male sexual dysfunction--the new millennium. Curr Opin Urol. 2000 Jul;10(4):313-7. (2000) Abstract

Henry GD, Byrne R, Hunyh TT, Abraham V, Annex BH, Hagen PO, Donatucci CF. Intracavernosal injections of vascular endothelial growth factor protects endothelial dependent corpora cavernosal smooth muscle relaxation in the hypercholesterolemic rabbit: a preliminary study. Int J Impot Res. 2000 Dec;12(6):334-9. (2000) Abstract

Male sexual function - the new millennium. Current Opinions in Urology 10: 313-317, 2000. (2000)

Methods and results of vasectomy reversal. AUA News, 5(5): 10, 2000. (2000)

Neurogenic bladder. In: The 5 Minute Urology Consult. Edited by: L.G. Gomella, Lippincott Williams & Wilkins, Baltimore, MD, 86-89, 2000. (2000)

1. Donatucci, DF: Alternative methods for management of prostatic outflow obstruction. Current Opinions in Urology, 9: 39-44, 1999. (1999)

Donatucci CF. Alternative methods for management of prostatic outflow obstruction. Curr Opin Urol. 1999 Jan;9(1):39-44. (1999) Abstract

1. Donatucci CF, and Ritter E: Correction of the buried penis in morbidly obese adults. Journal of Urology, 159:420-424, 1998. (1998)

2. Malloy BJ, Price DT, Donatucci CF, Price RR, Bienstock AM, Dole MK, Funk BL, and Schwinn DA: a1-Andrenergic receptor subtypes in human detrusor. Journal of Urology, 160:937-43, 1998. (1998)

3. Donatucci CF. Benign Prostatic Hyperplasia: Postoperative care. Surgery of the Prostate (Resnick MI and Thompson IA, eds.), Blackwell Pub, Inc., 1998:333-344. (1998)

4. Effect of Androgen Manipulation on the expression of Vascular Endothelial Growth Factor (VEGF) and Endothelial Nitric Oxide Synthase (eNOS) in Rat Erectile Tissue, International Journal of Impotence Research, 10:S54, 1998. (1998)

5. a1-Andrenergic receptor subtypes in human detrusor. Journal of Urology, 159:43, 1998. (1998)

Donatucci CF, Ritter EF. Management of the buried penis in adults. J Urol. 1998 Feb;159(2):420-4. (1998) Abstract

Malloy BJ, Price DT, Price RR, Bienstock AM, Dole MK, Funk BL, Rudner XL, Richardson CD, Donatucci CF, Schwinn DA. Alpha1-adrenergic receptor subtypes in human detrusor. J Urol. 1998 Sep;160(3 Pt 1):937-43. (1998) Abstract

1. Richardson CD, Donatucci CF, Page SO,Wilson KH, and Schwinn DA. Pharmacology of Tamsulosin: Saturation binding isotherms and competition analysis using cloned a-adrenergic receptor sybtypes. Prostate, 33:55-59, 1997. (1997)

2. Friedrichs, PA, Moul, JW, Wojcik, B, Donatucci, CF, Optenberg, S, Kreder, K, Thompson, IM Jr: A long-term study of the efficacy of treatment of localized prostate cancer. Urologic Oncology 3(5-6) 171-176, 1997. (1997)

Richardson CD, Donatucci CF, Page SO, Wilson KH, Schwinn DA. Pharmacology of tamsulosin: saturation-binding isotherms and competition analysis using cloned alpha 1-adrenergic receptor subtypes. Prostate. 1997 Sep 15;33(1):55-9. (1997) Abstract

1. Lacey JP, Donatucci CF, Price DT, et al. Effects of androgen deprivation on prostate alpha 1-adrenergic receptors. Urology 48(2):335-41, 1996. (1996)

2. Limoge JP, Olins E, Henderson D, Donatucci CF. Minimally invasive therapies in the treatment of erectile dysfunction in anticoagulated cases: a study of satisfaction and safety. J Urol 155(4):1276-9, 1996. (1996)

3. A Long-Term Study of the Efficacy of Treatment of Localized Prostate Cancer, Journal of Urology, 155:401A, 1996. (1996)

4. Post-Prostatectomy Erectile Dysfunction: An Outcome Analysis of Goal Directed Therapy. International Journal of Impotence Resedarch, 8:149, 1996. (1996)

4. Regulation of alpha 1-adrenergic Receptors by Androgens. Journal of Urology, 155:533A, 1996. (1996)

5. Management of the Buried Penis in Adults, International Journal of Impotence Research, 8:174, 1996. (1996)

Lacey JP, Donatucci CF, Price DT, Page SO, Bennett SA, Tenniswood MP, Schwinn DA. Effects of androgen deprivation on prostate alpha 1-adrenergic receptors. Urology. 1996 Aug;48(2):335-41. (1996) Abstract

Limoge JP, Olins E, Henderson D, Donatucci CF. Minimally invasive therapies in the treatment of erectile dysfunction in anticoagulated cases: a study of satisfaction and safety. J Urol. 1996 Apr;155(4):1276-9. (1996) Abstract

1. Trigo-Rocha F, Martinez-Pineiro L, Donatucci CF, Hsu GL, Lue TF and Tanagho EA: Sodium nitroprusside: physiologic effects as a nitric oxide donor in three species. Int J Impotence Res 7:49-56, 1995. (1995)

2. Trigo-Rocha F, Donatucci CF, Hsu GL, Nunes LL, Lue TF and Tanagho EA: The effect of intracavernous injection of potassium channel openers in monkeys and dogs. Int J Impotence Res 7:41-48, 1995. (1995)

Trigo-Rocha F, Donatucci CF, Hsu GL, Nunes L, Lue TF, Tanagho EA. The effect of intracavernous injection of potassium channel openers in monkeys and dogs. Int J Impot Res. 1995 Mar;7(1):41-8. (1995) Abstract

Trigo-Rocha F, Martinez-Piñeiro L, Donatucci CF, Hsu GL, Lue TF, Tanagho EA. Sodium nitroprusside: physiologic effects as a nitric oxide donor in three species. Int J Impot Res. 1995 Mar;7(1):49-56. (1995) Abstract

1. Thrasher JB, Donatucci CF. Malakoplakia and carcinoma of the prostate [letter;comment]. Br J Urol :73(1):111-112, 1994. (1994)

2. Trigo-Rocha F, Hsu GL, Donatucci CF, Martinez-Pineiro L, Lue TF, Tanagho EA. Intracellular mechanism of penile erection in monkeys. Neurourol Urodyn 13(1):71-80, 1994. (1994)

3. Spaulding H. Jr., Sutherland RS, Sklarew PR, Punja MK, Thrashe, JB, Vaughan TR, Donatucci CF. Effect of terfenadine on urination. Ann Allergy:72(5):441-5, 1994. (1994)

4. Thrasher JB, Donatucci CF. Malakoplakia and carcinoma of the prostate [letter]. Br J Urol 74(2):263, 1994. (1994)

Spaulding HS Jr, Sutherland RS, Sklarew PR, Punja MK, Thrasher JB, Vaughan TR, Donatucci CF. Effect of terfenadine on urination. Ann Allergy. 1994 May;72(5):441-5. (1994) Abstract

Thrasher JB, Donatucci CF. Malakoplakia and carcinoma of the prostate. Br J Urol. 1994 Aug;74(2):263. (1994) Abstract

Thrasher JB, Donatucci CF. Malakoplakia and carcinoma of the prostate. Br J Urol. 1994 Jan;73(1):111-2. (1994) Abstract

Trigo-Rocha F, Hsu GL, Donatucci CF, Martinez-Piñeiro L, Lue TF, Tanagho EA. Intracellular mechanism of penile erection in monkeys. Neurourol Urodyn. 1994;13(1):71-80. (1994) Abstract

1. von Heyden B, Donatucci CF, Marshall GA, Brock GB, Lue TF. A prostaglandin El dose-response study in man (see comments). J Urol:150(6):1825-8, 1993. (1993)

2. Kreder KJ, Stack R, Thrasher JB, Donatucci CF. Direct vision internal urethrotomy using topical anesthesia. Urology:42(5):548-50, 1993. (1993)

3. Donatucci CF, Trigo-Rocha F, Paick JS, Lue TF, Tanagho EA. The implantable penile venous compression device: experience in the chronic canine model. J Urol 149:1152-1155, 1993. (1993)

4. Donatucci CF, Kreder KJ, Berger N, Donohue RE, Raife MJ, Crawford ED: A randomized clinical trial comparing balloon dilation to transurethral resection of the prostate for benign prostatic hyperplasia. Urology 42:42-49, 1993. (1993)

5. Trigo-Rocha F, Hsu GL, Donatucci CF, Lue TF: The role of cyclic AMP, cyclic GMP, endothelium and non-adrenergic non-cholinergic neurotransmission in canine penile erection. J Urol 149:872-877, 1993. (1993)

Donatucci CF, Berger N, Kreder KJ, Donohue RE, Raife MJ, Crawford ED. Randomized clinical trial comparing balloon dilatation to transurethral resection of prostate for benign prostatic hyperplasia. Urology. 1993 Jul;42(1):42-9. (1993) Abstract

Donatucci CF, Lue TF. Erectile dysfunction in men under 40: etiology and treatment choice. Int J Impot Res. 1993 Jun;5(2):97-103. (1993) Abstract

Donatucci CF, Trigo-Rocha F, Paick JS, Lue TF, Tanagho EA. Implantable penile venous compression device: initial experience in the chronic canine model. J Urol. 1993 May;149(5):1152-5. (1993) Abstract

Kreder KJ, Stack R, Thrasher JB, Donatucci CF. Direct vision internal urethrotomy using topical anesthesia. Urology. 1993 Nov;42(5):548-50. (1993) Abstract

Paick JS, Donatucci CF, Lue TF. Anatomy of cavernous nerves distal to prostate: microdissection study in adult male cadavers. Urology. 1993 Aug;42(2):145-9. (1993) Abstract

Thrasher JB, Kreder KJ, Peterson NE, Donatucci CF. Lidocaine as topical anesthesia for bladder mappings and cold-cup biopsies. J Urol. 1993 Aug;150(2 Pt 1):335-6. (1993) Abstract

Trigo-Rocha F, Hsu GL, Donatucci CF, Lue TF. The role of cyclic adenosine monophosphate, cyclic guanosine monophosphate, endothelium and nonadrenergic, noncholinergic neurotransmission in canine penile erection. J Urol. 1993 Apr;149(4):872-7. (1993) Abstract

von Heyden B, Donatucci CF, Kaula N, Lue TF. Intracavernous pharmacotherapy for impotence: selection of appropriate agent and dose. J Urol. 1993 May;149(5 Pt 2):1288-90. (1993) Abstract

von Heyden B, Donatucci CF, Marshall GA, Brock GB, Lue TF. A prostaglandin E1 dose-response study in man. J Urol. 1993 Dec;150(6):1825-8. (1993) Abstract

2. Donatucci CF, Lue TF: The combined intracavernous injection and stimulation test: Diagnostic accuracy. J Urol 148:61-62, 1992. (1992)

Donatucci CF, Berger TG, Deshon GE Jr. Management of urinary tract in children with epidermolysis bullosa. Urology. 1992 Aug;40(2):137-42. (1992) Abstract

Donatucci CF, Lue TF. Correction of penile deformity assisted by intracavernous injection of papaverine. J Urol. 1992 Apr;147(4):1108-10. (1992) Abstract

Donatucci CF, Lue TF. The combined intracavernous injection and stimulation test: diagnostic accuracy. J Urol. 1992 Jul;148(1):61-2. (1992) Abstract

Thrasher JB, Sutherland RS, Limoge JP, Sims JE, Donatucci CF. Transrectal ultrasound and biopsy in diagnosis of malakoplakia of prostate. Urology. 1992 Mar;39(3):262-5. (1992) Abstract

Thrasher JB, Peterson NE, Donatucci CF. Lidocaine as a topical anesthetic for bladder biopsies. J Urol. 1991 Jun;145(6):1209-10. (1991) Abstract

1. Donatucci CF, Hunt ML, Deshon GE, Jr., Wade CE: Furosemide-induced disturbances of renal function in patients undergoing transurethral resection of the prostate. Urology 35(4):295-300, 1990. (1990)

Donatucci CF, Deshon GE Jr, Wade CE, Hunt M. Furosemide-induced disturbances of renal function in patients undergoing TURP. Urology. 1990 Apr;35(4):295-300. (1990) Abstract

Berger TG, Detlefs RL, Donatucci CF. Junctional epidermolysis bullosa, pyloric atresia, and genitourinary disease. Pediatr Dermatol. 1986 Feb;3(2):130-4. (1986) Abstract

Odom DG, Donatucci CF, Deshon GE. Mucinous adenocarcinoma of the prostate. Hum Pathol. 1986 Aug;17(8):863-5. (1986) Abstract

Donatucci CF. In anticipation of Flexner. Trans Stud Coll Physicians Phila. 1978 Jul;45(5):280-9. (1978) Abstract

Moore TM, Strauss JL, Herman S, and Donatucci CF.  Erectile dysfunction in early, middle, and late adulthood:  Symptom patterns and psychosocial correlates.  Journal of Sex & Marital Therapy 29(5): 381-399, 2003.

Silverstein A and Donatucci CF.  Bacterial biofilms and implantable prosthetic devices.  International Journal of Impotence Research S150-154, 2003.