Physicians

Co-Director, Duke Comprehensive Hemostasis and Thrombosis Center
Director, Duke Pediatric Sickle Cell Clinic

Department / Division
Pediatrics / Pediatrics-Hematology/Oncology

Address
DUMC 102382
Durham, NC 27710

Appointment Telephone
919-684-3401

Office Telephone
919-684-3401

Fax Telephone
919-681-7950

Training

• MD, Duke University School of Medicine, 1998

Residency

• Pediatrics, Duke University Medical Center, 1998-2001

Fellowship

• Pediatric Hematology-Oncology, University of Michigan Medical Center, 2001-2004
• National Hemophilia Foundation Clinical Fellowship, Hemostasis and Thrombosis, University of Michigan, 2003-2005

Other Training

• MS, Clinical Research Design and Statistical Analysis, University of Michigan, 2005

Clinical Interests
Bleeding, thrombotic, and hematologic disorders in children; pharmacogenetics testing

Research Interests
Pediatric Thrombosis
Prospective Multi-Center Evaluation of the Duration of Therapy for Thrombosis in Children
Thrombosis and Hemostasis Centers Research and Prevention Network
American Thrombosis and Hemostasis Network

Hemophilia
Public Health Surveillance of Bleeding Disorders Outside of Hemophilia Treatment Centers

ITP
Eltrombopag PETIT: Eltrombopag in Pediatric Patients with Thrombocytopenia

Sickle Cell Anemia
BABY HUG Follow-up Study II
TCD with Transfusions Changing to Hydroxyurea-Clinical Center
Pharmacokinetics and Relative Bioavailability of a Liquid Formulation of Hydroxyurea in Pediatric Patients with Sickle Cell Anemia

Pediatric Pharmacogenetics

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Alvarez, O; Miller, ST; Wang, WC; Luo, Z; McCarville, MB; Schwartz, GJ; Thompson, B; Howard, T; Iyer, RV; Rana, SR; Rogers, ZR; Sarnaik, SA; Thornburg, CD; Ware, RE; BABY HUG Investigators. Effect of hydroxyurea treatment on renal function parameters: results from the multi-center placebo-controlled BABY HUG clinical trial for infants with sickle cell anemia. Pediatric Blood and Cancer. 2012;59:668-674. (2012) Abstract

Grace, RF; Bennett, CM; Ritchey, AK; Jeng, M; Thornburg, CD; Lambert, MP; Neier, M; Recht, M; Kumar, M; Blanchette, V; Klaassen, RJ; Buchanan, GR; Kurth, MH; Nugent, DJ; Thompson, AA; Stine, K; Kalish, LA; Neufeld, EJ. Response to steroids predicts response to rituximab in pediatric chronic immune thrombocytopenia. Pediatric Blood and Cancer. 2012;58:221-225. (2012) Abstract

Josephson, CD; Granger, S; Assmann, SF; Castillejo, MI; Strauss, RG; Slichter, SJ; Steiner, ME; Journeycake, JM; Thornburg, CD; Bussel, J; Grabowski, EF; Neufeld, EJ; Savage, W; Sloan, SR. Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia. Blood. 2012;120:748-760. (2012) Abstract

Mouttalib, S; Rice, HE; Snyder, D; Levens, JS; Reiter, A; Soler, P; Rothman, JA; Thornburg, CD. Evaluation of partial and total splenectomy in children with sickle cell disease using an Internet-based registry. Pediatric Blood and Cancer. 2012;59:100-104. (2012) Abstract

Shah, N; Landi, D; Shah, R; Rothman, J; De Castro, LM; Thornburg, CD. Complications of implantable venous access devices in patients with sickle cell disease. American Journal of Hematology. 2012;87:224-226. (2012) Abstract

Thornburg, CD; Carpenter, S; Zappa, S; Munn, J; Leissinger, C. Current prescription of prophylactic factor infusions and perceived adherence for children and adolescents with haemophilia: a survey of haemophilia healthcare professionals in the United States. Haemophilia. 2012;18:568-574. (2012) Abstract

Greenway, A; Ware, RE; Thornburg, CD. Long-term results using hydroxyurea/phlebotomy for reducing secondary stroke risk in children with sickle cell anemia and iron overload. American Journal of Hematology. 2011;86:357-361. (2011) Abstract

Moran, C; Thornburg, CD; Barfield, RC. Ethical considerations for pharmacogenomic testing in pediatric clinical care and research. Pharmacogenomics. 2011;12:889-895. (2011) Abstract

Smith, GM; Lewis, VR; Whitworth, E; Gold, DT; Thornburg, CD. Growing up with sickle cell disease: a pilot study of a transition program for adolescents with sickle cell disease. Journal of Pediatric Hematology/Oncology. 2011;33:379-382. (2011) Abstract

Thornburg, CD; Calatroni, A; Panepinto, JA. Differences in health-related quality of life in children with sickle cell disease receiving hydroxyurea. Journal of Pediatric Hematology/Oncology. 2011;33:251-254. (2011) Abstract

Wang, WC; Ware, RE; Miller, ST; Iyer, RV; Casella, JF; Minniti, CP; Rana, S; Thornburg, CD; Rogers, ZR; Kalpatthi, RV; Barredo, JC; Brown, RC; Sarnaik, SA; Howard, TH; Wynn, LW; Kutlar, A; Armstrong, FD; Files, BA; Goldsmith, JC; Waclawiw, MA; Huang, X; Thompson, BW; BABY HUG investigators. Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG). Lancet. 2011;377:1663-1672. (2011) Abstract

Thompson, BW; Miller, ST; Rogers, ZR; Rees, RC; Ware, RE; Waclawiw, MA; Iyer, RV; Casella, JF; Luchtman-Jones, L; Rana, S; Thornburg, CD; Kalpatthi, RV; Barredo, JC; Brown, RC; Sarnaik, S; Howard, TH; Luck, L; Wang, WC. The pediatric hydroxyurea phase III clinical trial (BABY HUG): challenges of study design. Pediatric Blood and Cancer. 2010;54:250-255. (2010) Abstract

Thornburg, CD; Jones, E; Bomgaars, L; Gage, BF. Pediatric warfarin practice and pharmacogenetic testing. Thrombosis Research. 2010;126:e144-e146. (2010) Abstract

Thornburg, CD; Rogers, ZR; Jeng, MR; Rana, SR; Iyer, RV; Faughnan, L; Hassen, L; Marshall, J; McDonald, RP; Wang, WC; Huang, X; Rees, RC; BABY HUG Investigators. Adherence to study medication and visits: data from the BABY HUG trial. Pediatric Blood and Cancer. 2010;54:260-264. (2010) Abstract

Raffini, L; Thornburg, C. Testing children for inherited thrombophilia: more questions than answers. British Journal of Haematology. 2009;147:277-288. (2009) Abstract

Thornburg, CD; Dixon, N; Burgett, S; Mortier, NA; Schultz, WH; Zimmerman, SA; Bonner, M; Hardy, KK; Calatroni, A; Ware, RE. A pilot study of hydroxyurea to prevent chronic organ damage in young children with sickle cell anemia. Pediatric Blood and Cancer. 2009;52:609-615. (2009) Abstract

Thornburg, CD. Physicians' perceptions of adherence to prophylactic clotting factor infusions. Haemophilia. 2008;14:25-29. (2008) Abstract

Thornburg, CD; Dixon, N; Paulyson-Nuñez, K; Ortel, T. Thrombophilia screening in asymptomatic children. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 2008;121:597-604. (2008) Abstract

Thornburg, CD; Smith, PB; Smithwick, ML; Cotten, CM; Benjamin, DK. Association between thrombosis and bloodstream infection in neonates with peripherally inserted catheters. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 2008;122:782-785. (2008) Abstract

Thornburg, C; Pipe, S. Neonatal thromboembolic emergencies. Seminars in Fetal and Neonatal Medicine. 2006;11:198-206. (2006) Abstract

Thornburg, CD; Pipe, SW. Adherence to prophylactic infusions of factor VIII or factor IX for haemophilia. Haemophilia. 2006;12:198-199. (2006) Abstract

Thornburg, CD; Ware, RE. The utility of the autohaemolysis test for children with congenital haemolytic anaemia. International Journal of Laboratory Hematology. 2003;25:25-28. (2003) Abstract