Physicians

Chief, Gastrointestinal and Colorectal Surgery

Department / Division
Surgery / Surgical Oncology

Address
DUMC 3117
Durham, NC 27710

Appointment Telephone
919-684-4064

Office Telephone
919-681-3977

Fax Telephone
919-681-7934

Training

• MD, University of Wisconsin School of Medicine and Public Health, 1991

Residency

• General Surgery, Duke University Medical Center, 1991-1998

Fellowship

• Colorectal Surgery, Cleveland Clinic Foundation (Ohio), 1998-1999

Clinical Interests
Colorectal surgery; surgery for inflammatory bowel disease; benign anal/rectal surgery; sphincter-saving procedures for rectal cancer; fecal incontinence surgery; rectal prolapse repair; familial polyposis surgery; laparoscopic colon surgery; treatment of diverticulitis, anal cancer, Crohn's disease, ulcerative colitis, ileus, motility, neurogenic inflammation

Research Interests
Neurogenic inflammation
Ulcerative colitis
Crohn's disease
Neuropeptides
Receptors
Vanilloid receptor
Substance P
Intestinal motility
Colorectal cancer outcomes
Colon cancer
Rectal cancer

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Kalady, MF; Fields, RC; Klein, S; Nielsen, KC; Mantyh, CR; Ludwig, KA. Loop ileostomy closure at an ambulatory surgery facility: a safe and cost-effective alternative to routine hospitalization. Diseases of the Colon and Rectum. 2003;46:486-490. (2003) Abstract

Kihara, N; de la Fuente, SG; Fujino, K; Takahashi, T; Pappas, TN; Mantyh, CR. Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats. Gut. 2003;52:713-719. (2003) Abstract

de la Fuente, SG; Gottfried, MR; Lawson, DC; Harris, MB; Mantyh, CR; Pappas, TN. Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing. Journal of Gastrointestinal Surgery. 2003;7:96-101. (2003) Abstract

de la Fuente, SG; Levin, LS; Reynolds, JD; Olivares, C; Pappas, TN; Ludwig, KA; Mantyh, CR. Elective stoma construction improves outcomes in medically intractable pressure ulcers. Diseases of the Colon and Rectum. 2003;46:1525-1530. (2003) Abstract

de la Fuente, SG; Ludwig, KA; Mantyh, CR. Preoperative immune status determines anal condyloma recurrence after surgical excision. Diseases of the Colon and Rectum. 2003;46:367-373. (2003) Abstract

Mantyh, CR; Hull, TL; Fazio, VW. Coloplasty in low colorectal anastomosis: manometric and functional comparison with straight and colonic J-pouch anastomosis. Diseases of the Colon and Rectum. 2001;44:37-42. (2001) Abstract

Fazio, VW; Mantyh, CR; Hull, TL. Colonic "coloplasty": novel technique to enhance low colorectal or coloanal anastomosis. Diseases of the Colon and Rectum. 2000;43:1448-1450. (2000) Abstract

Mantyh, CR; McVey, DC; Vigna, SR. Extrinsic surgical denervation inhibits Clostridium difficile toxin A-induced enteritis in rats. Neuroscience Letters. 2000;292:95-98. (2000) Abstract

Mantyh, CR; Maggio, JE; Mantyh, PW; Vigna, SR; Pappas, TN. Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis. Digestive Diseases and Sciences. 1996;41:614-620. (1996) Abstract

Mantyh, CR; Pappas, TN; Lapp, JA; Washington, MK; Neville, LM; Ghilardi, JR; Rogers, SD; Mantyh, PW; Vigna, SR. Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. Gastroenterology. 1996;111:1272-1280. (1996) Abstract

Mantyh, PW; Rogers, SD; Ghilardi, JR; Maggio, JE; Mantyh, CR; Vigna, SR. Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo. Brain Research. 1996;719:8-13. (1996) Abstract

Mantyh, CR; Vigna, SR; Bollinger, RR; Mantyh, PW; Maggio, JE; Pappas, TN. Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. Gastroenterology. 1995;109:850-860. (1995) Abstract

Mantyh, PW; Allen, CJ; Ghilardi, JR; Rogers, SD; Mantyh, CR; Liu, H; Basbaum, AI; Vigna, SR; Maggio, JE. Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. Proceedings of the National Academy of Sciences of USA. 1995;92:2622-2626. (1995) Abstract

Mantyh, PW; DeMaster, E; Malhotra, A; Ghilardi, JR; Rogers, SD; Mantyh, CR; Liu, H; Basbaum, AI; Vigna, SR; Maggio, JE. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science. 1995;268:1629-1632. (1995) Abstract

Lawson, DC; Mantyh, CR; Pappas, TN. Effect of CGRP antagonist, alpha-CGRP 8-37, on acid secretion in the dog. Digestive Diseases and Sciences. 1994;39:1405-1408. (1994) Abstract

Mantyh, CR; Pappas, TN; Vigna, SR. Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract. Gastroenterology. 1994;107:1019-1030. (1994) Abstract

Mantyh, CR; Vigna, SR; Maggio, JE; Mantyh, PW; Bollinger, RR; Pappas, TN. Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors. Neuroscience Letters. 1994;178:255-259. (1994) Abstract

Kilgore, WR; Mantyh, PW; Mantyh, CR; McVey, DC; Vigna, SR. Bombesin/GRP-preferring and neuromedin B-preferring receptors in the rat urogenital system. Neuropeptides. 1993;24:43-52. (1993) Abstract

Bacay, AC; Mantyh, CR; Cohen, AH; Mantyh, PW; Fine, LG. Glomerular atrial natriuretic factor receptors in primary glomerulopathies: studies on human renal biopsies. American Journal of Kidney Diseases. 1989;14:386-395. (1989) Abstract

Gates, TS; Zimmerman, RP; Mantyh, CR; Vigna, SR; Mantyh, PW. Calcitonin gene-related peptide-alpha receptor binding sites in the gastrointestinal tract. Neuroscience. 1989;31:757-770. (1989) Abstract

Mantyh, PW; Gates, T; Mantyh, CR; Maggio, JE. Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. The Journal of Neuroscience. 1989;9:258-279. (1989) Abstract

Vigna, SR; Mantyh, CR; Soll, AH; Maggio, JE; Mantyh, PW. Substance P receptors on canine chief cells: localization, characterization, and function. The Journal of Neuroscience. 1989;9:2878-2886. (1989) Abstract

Zimmerman, RP; Gates, TS; Mantyh, CR; Vigna, SR; Welton, ML; Passaro, EP; Mantyh, PW. Vasoactive intestinal polypeptide receptor binding sites in the human gastrointestinal tract: localization by autoradiography. Neuroscience. 1989;31:771-783. (1989) Abstract

Bacay, AC; Mantyh, CR; Vigna, SR; Mantyh, PW. Receptor binding sites for atrial natriuretic factor are expressed by brown adipose tissue. Peptides. 1988;9:1021-1026. (1988) Abstract

Gates, TS; Zimmerman, RP; Mantyh, CR; Vigna, SR; Maggio, JE; Welton, ML; Passaro, EP; Mantyh, PW. Substance P and substance K receptor binding sites in the human gastrointestinal tract: localization by autoradiography. Peptides. 1988;9:1207-1219. (1988) Abstract

Kruger, L; Mantyh, PW; Sternini, C; Brecha, NC; Mantyh, CR. Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites. Brain Research. 1988;463:223-244. (1988) Abstract

Mantyh, CR; Gates, TS; Zimmerman, RP; Welton, ML; Passaro, EP; Vigna, SR; Maggio, JE; Kruger, L; Mantyh, PW. Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. Proceedings of the National Academy of Sciences of USA. 1988;85:3235-3239. (1988) Abstract

Mantyh, PW; Mantyh, CR; Gates, T; Vigna, SR; Maggio, JE. Receptor binding sites for substance P and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease. Neuroscience. 1988;25:817-837. (1988) Abstract

Popper, P; Mantyh, CR; Vigna, SR; Maggio, JE; Mantyh, PW. The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes. Peptides. 1988;9:257-267. (1988) Abstract

Zimmerman, RP; Gates, TS; Mantyh, CR; Vigna, SR; Boehmer, CG; Mantyh, PW. Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract. Peptides. 1988;9:1241-1253. (1988) Abstract

Akesson, TR; Mantyh, PW; Mantyh, CR; Matt, DW; Micevych, PE. Estrous cyclicity of 125I-cholecystokinin octapeptide binding in the ventromedial hypothalamic nucleus. Evidence for downmodulation by estrogen. Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships. 1987;45:257-262. (1987) Abstract

Mantyh, CR; Kruger, L; Brecha, NC; Mantyh, PW. Localization of specific binding sites for atrial natriuretic factor in the central nervous system of rat, guinea pig, cat and human. Brain Research. 1987;412:329-342. (1987) Abstract

Vigna, SR; Mantyh, CR; Giraud, AS; Soll, AH; Walsh, JH; Mantyh, PW. Localization of specific binding sites for bombesin in the canine gastrointestinal tract. Gastroenterology. 1987;93:1287-1295. (1987) Abstract

Mantyh, CR; Kruger, L; Brecha, NC; Mantyh, PW. Localization of specific binding sites for atrial natriuretic factor in peripheral tissues of the guinea pig, rat, and human. Hypertension. 1986;8:712-721. (1986) Abstract

Mantyh, CR; Brecha, NC; Soon-Shiong, P; Mantyh, PW. Specific binding sites for atrial natriuretic factor in the human kidney. New England Journal of Medicine. 1985;312:1710. (1985) Abstract

Mantyh, CR; Mantyh, PW. Differential localization of cholecystokinin-8 binding sites in the rat vs. the guinea pig brain. European Journal of Pharmacology. 1985;113:137-139. (1985) Abstract