Chief, Gastrointestinal and Colorectal Surgery
Department / Division
Surgery /
Surgical Oncology
Address
DUMC 3117
Durham, NC 27710
Appointment Telephone
919-684-4064
Office Telephone
919-681-3977
Fax Telephone
919-681-7934
Clinical Interests
Colorectal surgery; surgery for inflammatory bowel disease; benign anal/rectal surgery; sphincter-saving procedures for rectal cancer; fecal incontinence surgery; rectal prolapse repair; familial polyposis surgery; laparoscopic colon surgery; treatment of diverticulitis, anal cancer, Crohn's disease, ulcerative colitis, ileus, motility, neurogenic inflammation
Research Interests
Neurogenic inflammation
Ulcerative colitis
Crohn's disease
Neuropeptides
Receptors
Vanilloid receptor
Substance P
Intestinal motility
Colorectal cancer outcomes
Colon cancer
Rectal cancer
This faculty member has no reported relationships with industry.
Representative Publications
Kalady, MF; Fields, RC; Klein, S; Nielsen, KC; Mantyh, CR; Ludwig, KA. Loop ileostomy closure at an ambulatory surgery facility: a safe and cost-effective alternative to routine hospitalization. Diseases of the Colon and Rectum. 2003;46:486-490.
(2003)
Abstract
Kihara, N; de la Fuente, SG; Fujino, K; Takahashi, T; Pappas, TN; Mantyh, CR. Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats. Gut. 2003;52:713-719.
(2003)
Abstract
de la Fuente, SG; Gottfried, MR; Lawson, DC; Harris, MB; Mantyh, CR; Pappas, TN. Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing. Journal of Gastrointestinal Surgery. 2003;7:96-101.
(2003)
Abstract
de la Fuente, SG; Levin, LS; Reynolds, JD; Olivares, C; Pappas, TN; Ludwig, KA; Mantyh, CR. Elective stoma construction improves outcomes in medically intractable pressure ulcers. Diseases of the Colon and Rectum. 2003;46:1525-1530.
(2003)
Abstract
de la Fuente, SG; Ludwig, KA; Mantyh, CR. Preoperative immune status determines anal condyloma recurrence after surgical excision. Diseases of the Colon and Rectum. 2003;46:367-373.
(2003)
Abstract
Mantyh, CR; Hull, TL; Fazio, VW. Coloplasty in low colorectal anastomosis: manometric and functional comparison with straight and colonic J-pouch anastomosis. Diseases of the Colon and Rectum. 2001;44:37-42.
(2001)
Abstract
Fazio, VW; Mantyh, CR; Hull, TL. Colonic "coloplasty": novel technique to enhance low colorectal or coloanal anastomosis. Diseases of the Colon and Rectum. 2000;43:1448-1450.
(2000)
Abstract
Mantyh, CR; McVey, DC; Vigna, SR. Extrinsic surgical denervation inhibits Clostridium difficile toxin A-induced enteritis in rats. Neuroscience Letters. 2000;292:95-98.
(2000)
Abstract
Mantyh, CR; Maggio, JE; Mantyh, PW; Vigna, SR; Pappas, TN. Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis. Digestive Diseases and Sciences. 1996;41:614-620.
(1996)
Abstract
Mantyh, CR; Pappas, TN; Lapp, JA; Washington, MK; Neville, LM; Ghilardi, JR; Rogers, SD; Mantyh, PW; Vigna, SR. Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. Gastroenterology. 1996;111:1272-1280.
(1996)
Abstract
Mantyh, PW; Rogers, SD; Ghilardi, JR; Maggio, JE; Mantyh, CR; Vigna, SR. Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo. Brain Research. 1996;719:8-13.
(1996)
Abstract
Mantyh, CR; Vigna, SR; Bollinger, RR; Mantyh, PW; Maggio, JE; Pappas, TN. Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. Gastroenterology. 1995;109:850-860.
(1995)
Abstract
Mantyh, PW; Allen, CJ; Ghilardi, JR; Rogers, SD; Mantyh, CR; Liu, H; Basbaum, AI; Vigna, SR; Maggio, JE. Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. Proceedings of the National Academy of Sciences of USA. 1995;92:2622-2626.
(1995)
Abstract
Mantyh, PW; DeMaster, E; Malhotra, A; Ghilardi, JR; Rogers, SD; Mantyh, CR; Liu, H; Basbaum, AI; Vigna, SR; Maggio, JE. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science. 1995;268:1629-1632.
(1995)
Abstract
Lawson, DC; Mantyh, CR; Pappas, TN. Effect of CGRP antagonist, alpha-CGRP 8-37, on acid secretion in the dog. Digestive Diseases and Sciences. 1994;39:1405-1408.
(1994)
Abstract
Mantyh, CR; Pappas, TN; Vigna, SR. Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract. Gastroenterology. 1994;107:1019-1030.
(1994)
Abstract
Mantyh, CR; Vigna, SR; Maggio, JE; Mantyh, PW; Bollinger, RR; Pappas, TN. Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors. Neuroscience Letters. 1994;178:255-259.
(1994)
Abstract
Kilgore, WR; Mantyh, PW; Mantyh, CR; McVey, DC; Vigna, SR. Bombesin/GRP-preferring and neuromedin B-preferring receptors in the rat urogenital system. Neuropeptides. 1993;24:43-52.
(1993)
Abstract
Bacay, AC; Mantyh, CR; Cohen, AH; Mantyh, PW; Fine, LG. Glomerular atrial natriuretic factor receptors in primary glomerulopathies: studies on human renal biopsies. American Journal of Kidney Diseases. 1989;14:386-395.
(1989)
Abstract
Gates, TS; Zimmerman, RP; Mantyh, CR; Vigna, SR; Mantyh, PW. Calcitonin gene-related peptide-alpha receptor binding sites in the gastrointestinal tract. Neuroscience. 1989;31:757-770.
(1989)
Abstract
Mantyh, PW; Gates, T; Mantyh, CR; Maggio, JE. Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. The Journal of Neuroscience. 1989;9:258-279.
(1989)
Abstract
Vigna, SR; Mantyh, CR; Soll, AH; Maggio, JE; Mantyh, PW. Substance P receptors on canine chief cells: localization, characterization, and function. The Journal of Neuroscience. 1989;9:2878-2886.
(1989)
Abstract
Zimmerman, RP; Gates, TS; Mantyh, CR; Vigna, SR; Welton, ML; Passaro, EP; Mantyh, PW. Vasoactive intestinal polypeptide receptor binding sites in the human gastrointestinal tract: localization by autoradiography. Neuroscience. 1989;31:771-783.
(1989)
Abstract
Bacay, AC; Mantyh, CR; Vigna, SR; Mantyh, PW. Receptor binding sites for atrial natriuretic factor are expressed by brown adipose tissue. Peptides. 1988;9:1021-1026.
(1988)
Abstract
Gates, TS; Zimmerman, RP; Mantyh, CR; Vigna, SR; Maggio, JE; Welton, ML; Passaro, EP; Mantyh, PW. Substance P and substance K receptor binding sites in the human gastrointestinal tract: localization by autoradiography. Peptides. 1988;9:1207-1219.
(1988)
Abstract
Kruger, L; Mantyh, PW; Sternini, C; Brecha, NC; Mantyh, CR. Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites. Brain Research. 1988;463:223-244.
(1988)
Abstract
Mantyh, CR; Gates, TS; Zimmerman, RP; Welton, ML; Passaro, EP; Vigna, SR; Maggio, JE; Kruger, L; Mantyh, PW. Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. Proceedings of the National Academy of Sciences of USA. 1988;85:3235-3239.
(1988)
Abstract
Mantyh, PW; Mantyh, CR; Gates, T; Vigna, SR; Maggio, JE. Receptor binding sites for substance P and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease. Neuroscience. 1988;25:817-837.
(1988)
Abstract
Popper, P; Mantyh, CR; Vigna, SR; Maggio, JE; Mantyh, PW. The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes. Peptides. 1988;9:257-267.
(1988)
Abstract
Zimmerman, RP; Gates, TS; Mantyh, CR; Vigna, SR; Boehmer, CG; Mantyh, PW. Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract. Peptides. 1988;9:1241-1253.
(1988)
Abstract
Akesson, TR; Mantyh, PW; Mantyh, CR; Matt, DW; Micevych, PE. Estrous cyclicity of 125I-cholecystokinin octapeptide binding in the ventromedial hypothalamic nucleus. Evidence for downmodulation by estrogen. Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships. 1987;45:257-262.
(1987)
Abstract
Mantyh, CR; Kruger, L; Brecha, NC; Mantyh, PW. Localization of specific binding sites for atrial natriuretic factor in the central nervous system of rat, guinea pig, cat and human. Brain Research. 1987;412:329-342.
(1987)
Abstract
Vigna, SR; Mantyh, CR; Giraud, AS; Soll, AH; Walsh, JH; Mantyh, PW. Localization of specific binding sites for bombesin in the canine gastrointestinal tract. Gastroenterology. 1987;93:1287-1295.
(1987)
Abstract
Mantyh, CR; Kruger, L; Brecha, NC; Mantyh, PW. Localization of specific binding sites for atrial natriuretic factor in peripheral tissues of the guinea pig, rat, and human. Hypertension. 1986;8:712-721.
(1986)
Abstract
Mantyh, CR; Brecha, NC; Soon-Shiong, P; Mantyh, PW. Specific binding sites for atrial natriuretic factor in the human kidney. New England Journal of Medicine. 1985;312:1710.
(1985)
Abstract
Mantyh, CR; Mantyh, PW. Differential localization of cholecystokinin-8 binding sites in the rat vs. the guinea pig brain. European Journal of Pharmacology. 1985;113:137-139.
(1985)
Abstract
