Director, Cardiac Care Unit
Department / Division
Medicine / Medicine - Cardiology
Durham, NC 27710
Critical care; general inpatient and outpatient cardiology; care of patients with acute and chronic ischemic heart disease; congestive heart failure; valvular heart disease; atrial fibrillation
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. I serve as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. I have also studied the effects of genetic variation on heart disease. I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
Granger, CB. Accelerating ST-segment elevation myocardial infarction care: emergency medical services take center stage. JACC: Cardiovascular Interventions. 2009;2:347-349. (2009) Abstract
Hernandez, AF; Granger, CB. Advancing care for acute heart failure--no time to relax. Lancet. 2009;373:1401-1402. (2009) Abstract
Mehta, RH; Starr, AZ; Lopes, RD; Hochman, JS; Widimsky, P; Pieper, KS; Armstrong, PW; Granger, CB; APEX AMI Investigators. Incidence of and outcomes associated with ventricular tachycardia or fibrillation in patients undergoing primary percutaneous coronary intervention. JAMA: Journal of the American Medical Association. 2009;301:1779-1789. (2009) Abstract
Mehta, SR; Granger, CB; Boden, WE; Steg, PG; Bassand, JP; Faxon, DP; Afzal, R; Chrolavicius, S; Jolly, SS; Widimsky, P; Avezum, A; Rupprecht, HJ; Zhu, J; Col, J; Natarajan, MK; Horsman, C; Fox, KA; Yusuf, S; TIMACS Investigators. Early versus delayed invasive intervention in acute coronary syndromes. New England Journal of Medicine. 2009;360:2165-2175. (2009) Abstract
Granger, CB; Steg, PG; Peterson, E; López-Sendón, J; Van de Werf, F; Kline-Rogers, E; Allegrone, J; Dabbous, OH; Klein, W; Fox, KA; Eagle, KA; GRACE Investigators. Medication performance measures and mortality following acute coronary syndromes. American Journal of Medicine. 2005;118:858-865. (2005) Abstract
Granger, CB; Goldberg, RJ; Dabbous, O; Pieper, KS; Eagle, KA; Cannon, CP; Van De Werf, F; Avezum, A; Goodman, SG; Flather, MD; Fox, KA; Global Registry of Acute Coronary Events Investigators. Predictors of hospital mortality in the global registry of acute coronary events. Archives of Internal Medicine. 2003;163:2345-2353. (2003) Abstract
Granger, CB; McMurray, JJ; Yusuf, S; Held, P; Michelson, EL; Olofsson, B; Ostergren, J; Pfeffer, MA; Swedberg, K; CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet. 2003;362:772-776. (2003) Abstract