Physicians

Pathology Course Director, Duke University School of Medicine

Departments / Divisions

• Pathology / Pathology Clinical Services
• Medicine / Medicine-Neurology

Address
DUMC 3712
Durham, NC 27710

Appointment Telephone
919-684-3641

Office Telephone
919-684-3994

Fax Telephone
919-684-3670

Training

• MD, University of Louisville School of Medicine (Kentucky), 1983

Residency

• Pathology, University of California–Los Angeles Medical Center (California), 1983-1987

Fellowship

• Neuropathology, Duke University Medical Center, 1987-1989

Clinical Interests
Autopsy and surgical neuropathology, neurodegenerative disorders, post-mortem diagnosis of dementia

Research Interests
Clinical Interests
Christine Hulette MD is Professor of Pathology and Neuropathology at Duke University Medical Center. She is Attending Physician and Neuropathologist on the Autopsy Service and serves in the Pathology Residency training program. She is consultant to the Surgical Neuropathology service and is expert in the post mortem diagnosis of neurodegenerative disorders.

Research Interests
Dr. Hulette is known for developing strong collaborations and coordinating productive research programs with the Departments of Pathology, Medicine (Neurology) and Psychiatry. She has served as director of the Kathleen Price Bryan Brain Bank, a repository of greater than 1300 well characterized specimens which are used for a wide variety of research programs. The Rapid Autopsy Program is unique, enjoying national and international recognition. Dr Hulette is global leader and advisor to autopsy and tissue banking programs. Her work has resulted in over 200 publications.

Educational Interests
Dr. Hulette is responsible for a Neuroanatomy course structured to meet the educational needs of Pathologist Assistant students. She developed the Neuroanatomy Web Resource.
http://pathology.mc.duke.edu/neuropath/nawr/nawr_index.html with a grant from the Duke Center for Instructional Technology,

She has served as Pathology Course Director for Duke School of Medicine since 2004. She played a key role in integrating Pathology instruction into the multidisciplinary “Body and Disease” beginning in 2005 and introduced virtual microscopy in 2007. Most recently she has integrated Microbiology into the Pathology curriculum.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Naj, AC; Jun, G; Beecham, GW; Wang, LS; Vardarajan, BN; Buros, J; Gallins, PJ; Buxbaum, JD; Jarvik, GP; Crane, PK; Larson, EB; Bird, TD; Boeve, BF; Graff-Radford, NR; De Jager, PL; Evans, D; Schneider, JA; Carrasquillo, MM; Ertekin-Taner, N; Younkin, SG; Cruchaga, C; Kauwe, JS; Nowotny, P; Kramer, P; Hardy, J; Huentelman, MJ; Myers, AJ; Barmada, MM; Demirci, FY; Baldwin, CT; Green, RC; Rogaeva, E; St George-Hyslop, P; Arnold, SE; Barber, R; Beach, T; Bigio, EH; Bowen, JD; Boxer, A; Burke, JR; Cairns, NJ; Carlson, CS; Carney, RM; Carroll, SL; Chui, HC; Clark, DG; Corneveaux, J; Cotman, CW; Cummings, JL; DeCarli, C; DeKosky, ST; Diaz-Arrastia, R; Dick, M; Dickson, DW; Ellis, WG; Faber, KM; Fallon, KB; Farlow, MR; Ferris, S; Frosch, MP; Galasko, DR; Ganguli, M; Gearing, M; Geschwind, DH; Ghet. . . Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 2011;43:436-441. (2011) Abstract

Reynolds, RM; Boswell, E; Hulette, CM; Cummings, TJ; Haglund, MM; Boswell, E; Hulette, CM; Cumm Ings, TJ; Haglund, MM. Sudden death from diffuse leptomeningeal oligodendrogliomatosis. Journal of Neurosurgery: Spine. 2011;15:625-629. (2011) Abstract

Liang, WS; Dunckley, T; Beach, TG; Grover, A; Mastroeni, D; Ramsey, K; Caselli, RJ; Kukull, WA; McKeel, D; Morris, JC; Hulette, CM; Schmechel, D; Reiman, EM; Rogers, J; Stephan, DA. Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology. Neurobiology of Aging. 2010;31:549-566. (2010) Abstract

Naylor, JC; Kilts, JD; Hulette, CM; Steffens, DC; Blazer, DG; Ervin, JF; Strauss, JL; Allen, TB; Massing, MW; Payne, VM; Youssef, NA; Shampine, LJ; Marx, CE. Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 2010;1801:951-959. (2010) Abstract

Van Deerlin, VM; Sleiman, PM; Martinez-Lage, M; Chen-Plotkin, A; Wang, LS; Graff-Radford, NR; Dickson, DW; Rademakers, R; Boeve, BF; Grossman, M; Arnold, SE; Mann, DM; Pickering-Brown, SM; Seelaar, H; Heutink, P; van Swieten, JC; Murrell, JR; Ghetti, B; Spina, S; Grafman, J; Hodges, J; Spillantini, MG; Gilman, S; Lieberman, AP; Kaye, JA; Woltjer, RL; Bigio, EH; Mesulam, M; Al-Sarraj, S; Troakes, C; Rosenberg, RN; White, CL; Ferrer, I; Lladó, A; Neumann, M; Kretzschmar, HA; Hulette, CM; Welsh-Bohmer, KA; Miller, BL; Alzualde, A; Lopez de Munain, A; McKee, AC; Gearing, M; Levey, AI; Lah, JJ; Hardy, J; Rohrer, JD; Lashley, T; Mackenzie, IR; Feldman, HH; Hamilton, RL; Dekosky, ST; van der Zee, J; Kumar-Singh, S; Van Broeckhoven, C; Mayeux, R; Vonsattel, JP; Troncoso, JC; Kril, JJ; Kwok, JB; Ha. . . Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics. 2010;42:234-239. (2010) Abstract

Hulette, CM; Ervin, JF; Edmonds, Y; Antoine, S; Stewart, N; Szymanski, MH; Hayden, KM; Pieper, CF; Burke, JR; Welsh-Bohmer, KA. Cerebrovascular smooth muscle actin is increased in nondemented subjects with frequent senile plaques at autopsy: implications for the pathogenesis of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 2009;68:417-424. (2009) Abstract

Stopa, EG; Butala, P; Salloway, S; Johanson, CE; Gonzalez, L; Tavares, R; Hovanesian, V; Hulette, CM; Vitek, MP; Cohen, RA. Cerebral cortical arteriolar angiopathy, vascular beta-amyloid, smooth muscle actin, Braak stage, and APOE genotype. Stroke. 2008;39:814-821. (2008) Abstract

Ervin, JF; Heinzen, EL; Cronin, KD; Goldstein, D; Szymanski, MH; Burke, JR; Welsh-Bohmer, KA; Hulette, CM. Postmortem delay has minimal effect on brain RNA integrity. Journal of Neuropathology and Experimental Neurology. 2007;66:1093-1099. (2007) Abstract

Trembath, D; Ervin, JF; Broom, L; Szymanski, M; Welsh-Bohmer, K; Pieper, C; Hulette, CM. The distribution of cerebrovascular amyloid in Alzheimer's disease varies with ApoE genotype. Acta Neuropathologica. 2007;113:23-31. (2007) Abstract

Corder, EH; Ervin, JF; Lockhart, E; Szymanski, MH; Schmechel, DE; Hulette, CM. Cardiovascular damage in Alzheimer disease: autopsy findings from the Bryan ADRC. Journal of Biomedicine and Biotechnology. 2005;2005:189-197. (2005) Abstract

Mott, RT; Dickson, DW; Trojanowski, JQ; Zhukareva, V; Lee, VM; Forman, M; Van Deerlin, V; Ervin, JF; Wang, DS; Schmechel, DE; Hulette, CM. Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias. Journal of Neuropathology and Experimental Neurology. 2005;64:420-428. (2005) Abstract

Ervin, JF; Pannell, C; Szymanski, M; Welsh-Bohmer, K; Schmechel, DE; Hulette, CM. Vascular smooth muscle actin is reduced in Alzheimer disease brain: a quantitative analysis. Journal of Neuropathology and Experimental Neurology. 2004;63:735-741. (2004) Abstract

Hulette, CM. Brain banking in the United States. Journal of Neuropathology and Experimental Neurology. 2003;62:715-722. (2003) Abstract

Trembath, Y; Rosenberg, C; Ervin, JF; Schmechel, DE; Gaskell, P; Pericak-Vance, M; Vance, J; Hulette, CM. Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease. Acta Neuropathologica. 2003;105:484-488. (2003) Abstract

Cummings, TJ; Strum, JC; Yoon, LW; Szymanski, MH; Hulette, CM. Recovery and expression of messenger RNA from postmortem human brain tissue. Modern Pathology. 2001;14:1157-1161. (2001) Abstract

Rosenberg, CK; Cummings, TJ; Saunders, AM; Widico, C; McIntyre, LM; Hulette, CM. Dementia with Lewy bodies and Alzheimer's disease. Acta Neuropathologica. 2001;102:621-626. (2001) Abstract

Rosenberg, CK; Pericak-Vance, MA; Saunders, AM; Gilbert, JR; Gaskell, PC; Hulette, CM. Lewy body and Alzheimer pathology in a family with the amyloid-beta precursor protein APP717 gene mutation. Acta Neuropathologica. 2000;100:145-152. (2000) Abstract

Hulette, CM; Pericak-Vance, MA; Roses, AD; Schmechel, DE; Yamaoka, LH; Gaskell, PC; Welsh-Bohmer, KA; Crowther, RA; Spillantini, MG. Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21-22 (FTDP-17): Duke Family 1684. Journal of Neuropathology and Experimental Neurology. 1999;58:859-866. (1999) Abstract

Stern, RC; Hulette, CM. Paraneoplastic limbic encephalitis associated with small cell carcinoma of the prostate. Modern Pathology. 1999;12:814-818. (1999) Abstract

Xu, PT; Gilbert, JR; Qiu, HL; Ervin, J; Rothrock-Christian, TR; Hulette, C; Schmechel, DE. Specific regional transcription of apolipoprotein E in human brain neurons. American Journal of Pathology. 1999;154:601-611. (1999) Abstract

Chu, CT; Gray, L; Goldstein, LB; Hulette, CM. Diagnosis of intracranial vasculitis: a multi-disciplinary approach. Journal of Neuropathology and Experimental Neurology. 1998;57:30-38. (1998) Abstract

Einstein, G; Patel, V; Bautista, P; Kenna, M; Melone, L; Fader, R; Karson, K; Mann, S; Saunders, AM; Hulette, C; Mash, D; Roses, AD; Schmechel, DE. Intraneuronal ApoE in human visual cortical areas reflects the staging of Alzheimer disease pathology. Journal of Neuropathology and Experimental Neurology. 1998;57:1190-1201. (1998) Abstract

Hulette, CM; Welsh-Bohmer, KA; Murray, MG; Saunders, AM; Mash, DC; McIntyre, LM. Neuropathological and neuropsychological changes in "normal" aging: evidence for preclinical Alzheimer disease in cognitively normal individuals. Journal of Neuropathology and Experimental Neurology. 1998;57:1168-1174. (1998) Abstract

Hulette, CM; Welsh-Bohmer, KA; Crain, B; Szymanski, MH; Sinclaire, NO; Roses, AD. Rapid brain autopsy. The Joseph and Kathleen Bryan Alzheimer's Disease Research Center experience. Archives of Pathology and Laboratory Medicine. 1997;121:615-618. (1997) Abstract

White, LE; Andrews, TJ; Hulette, C; Richards, A; Groelle, M; Paydarfar, J; Purves, D. Structure of the human sensorimotor system. I: Morphology and cytoarchitecture of the central sulcus. Cerebral Cortex. 1997;7:18-30. (1997) Abstract

White, LE; Andrews, TJ; Hulette, C; Richards, A; Groelle, M; Paydarfar, J; Purves, D. Structure of the human sensorimotor system. II: Lateral symmetry. Cerebral Cortex. 1997;7:31-47. (1997) Abstract

Hulette, CM. Microglioma, a histiocytic neoplasm of the central nervous system. Modern Pathology. 1996;9:316-319. (1996) Abstract

Rubin, P; Hulette, C; Khawly, JA; Elkordy, M; Hussein, A; Vredenburgh, JJ; Jaffe, GJ; Peters, WP. Ocular toxicity following high dose chemotherapy and autologous transplant. Bone Marrow Transplantation. 1996;18:253-256. (1996) Abstract

Saunders, AM; Hulette, O; Welsh-Bohmer, KA; Schmechel, DE; Crain, B; Burke, JR; Alberts, MJ; Strittmatter, WJ; Breitner, JC; Rosenberg, C. Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet. 1996;348:90-93. (1996) Abstract

Yamaoka, LH; Welsh-Bohmer, KA; Hulette, CM; Gaskell, PC; Murray, M; Rimmler, JL; Helms, BR; Guerra, M; Roses, AD; Schmechel, DE; Pericak-Vance, MA. Linkage of frontotemporal dementia to chromosome 17: clinical and neuropathological characterization of phenotype. American Journal of Human Genetics. 1996;59:1306-1312. (1996) Abstract

Hulette, C; Mirra, S; Wilkinson, W; Heyman, A; Fillenbaum, G; Clark, C. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part IX. A prospective cliniconeuropathologic study of Parkinson's features in Alzheimer's disease. Neurology. 1995;45:1991-1995. (1995) Abstract

Smith, MS; Schambra, UB; Wilson, KH; Page, SO; Hulette, C; Light, AR; Schwinn, DA. alpha 2-Adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha 2-adrenergic receptor subtypes at four distinct levels. Brain Research. 1995;34:109-117. (1995) Abstract

Boyko, OB; Alston, SR; Fuller, GN; Hulette, CM; Johnson, GA; Burger, PC. Utility of postmortem magnetic resonance imaging in clinical neuropathology. Archives of Pathology and Laboratory Medicine. 1994;118:219-225. (1994) Abstract

Burke, JR; Wingfield, MS; Lewis, KE; Roses, AD; Lee, JE; Hulette, C; Pericak-Vance, MA; Vance, JM. The Haw River syndrome: dentatorubropallidoluysian atrophy (DRPLA) in an African-American family. Nature Genetics. 1994;7:521-524. (1994) Abstract

Han, SH; Hulette, C; Saunders, AM; Einstein, G; Pericak-Vance, M; Strittmatter, WJ; Roses, AD; Schmechel, DE. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Experimental Neurology. 1994;128:13-26. (1994) Abstract

Lane, KL; Brown, P; Howell, DN; Crain, BJ; Hulette, CM; Burger, PC; DeArmond, SJ. Creutzfeldt-Jakob disease in a pregnant woman with an implanted dura mater graft. Neurosurgery. 1994;34:737-739. (1994) Abstract

Andrews, PI; Hulette, CM. An infant with macrocephaly, abnormal neuronal migration and persistent olfactory ventricles. Clinical Neuropathology. 1993;12:13-18. (1993) Abstract

Mihovilovic, M; Hulette, C; Mittelstaedt, J; Austin, C; Roses, AD. Nicotinic neuronal acetylcholine receptor alpha-3 subunit transcription in normal and myasthenic thymus. Annals of the New York Academy of Sciences. 1993;681:83-96. (1993) Abstract

Schmechel, DE; Saunders, AM; Strittmatter, WJ; Crain, BJ; Hulette, CM; Joo, SH; Pericak-Vance, MA; Goldgaber, D; Roses, AD. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of USA. 1993;90:9649-9653. (1993) Abstract

Hulette, CM; Downey, BT; Burger, PC. Macrophage markers in diagnostic neuropathology. American Journal of Surgical Pathology. 1992;16:493-499. (1992) Abstract

Hulette, CM; Earl, NL; Crain, BJ. Evaluation of cerebral biopsies for the diagnosis of dementia. Archives of Neurology. 1992;49:28-31. (1992) Abstract

Farmer, TW; Wingfield, MS; Lynch, SA; Vogel, FS; Hulette, C; Katchinoff, B; Jacobson, PL. Ataxia, chorea, seizures, and dementia. Pathologic features of a newly defined familial disorder. Archives of Neurology. 1989;46:774-779. (1989) Abstract

Hulette, CM; Effros, RB; Walford, RL. Immunization of normal human splenocytes in vitro to produce human monoclonal antibodies to cellular antigens. Tissue Antigens: immune response genetics. 1987;30:25-33. (1987) Abstract

Hulette, CM; Walford, RL. Immunological aspects of Alzheimer disease: a review. Alzheimer Disease and Associated Disorders. 1987;1:72-82. (1987) Abstract

Effros, RB; Hulette, CM; Ettenger, R; Dillard, LC; Zeller, E; Duong, R; Walford, RL. A human-human hybridoma secreting anti-HLA class II antibody. Journal of Immunology. 1986;137:1599-1603. (1986) Abstract

Hulette, C; Carstens, PH. Electron-dense deposits in extraglomerular vascular structures in IgA nephropathy. A retrospective study. The Nephron Journals. 1985;39:179-183. (1985) Abstract

Hulette, CM; Effros, RB; Dillard, LC; Walford, RL. Production of a human monoclonal antibody to HLA by human-human hybridoma technology. A preliminary report. American Journal of Pathology. 1985;121:10-14. (1985) Abstract

Hulette, CM; Walford, RL. HLA and complement studies in Alzheimer's disease. Bulletin of Clinical Neurosciences. 1985;50:32-35. (1985) Abstract