Chief, Otolaryngology/Neuroanesthesia
Medical Director, Neurosciences Intensive Care Unit

Department / Division:
Anesthesiology / Anesthesiology

Address:
DUMC 3094
Durham, NC 27710

Appointment Telephone:
919-681-2150

Office Telephone:
919-681-2150

Fax Telephone:
919-681-4698

• MD, Hahnemann (Drexel University College of Medicine, Pennsylvania), 1977

• Internal Medicine, Robert Packer Hospital/Guthrie Clinic (Pennsylvania), 1977-1980
• Anesthesiology, Johns Hopkins Hospital (Maryland), 1981-1983

• Critical Care Medicine, Maryland Institute for Emergency Medical Services, 1980

Clinical Interests:
Neuro-critical care, neuroanesthesiology

Research Interests:
My long term career interests center around anesthesia and critical care for patients with life-threatening neurological illnesses. I am particularly interested in respiratory dysfunction as the result of neurocritical illness.  
Recently I have been involved with projects to explore the pathophysiology of cerebral vasospasm following subarachnoid hemorrhage in vivo and in vitro models, the role of magnesium in cerebral vasospasm, and technical aspects of neuroanesthesia related to awake craniotomy and endovascular cerebrovascular surgery.

Representative Publications:
Borel CO, McKee A, Parra A, Haglund MM, Solan A, Prabhakar V, Sheng H, Warner DS, Niklason L. Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage.  Stroke.  2003 Feb;34(2):427-33. (2003) Abstract

Fabling JM, Gan TJ, El-Moalem HE, Warner DS, Borel CO. A randomized, double-blind comparison of ondansetron versus placebo for prevention of nausea and vomiting after infratentorial craniotomy.  J Neurosurg Anesthesiol.  2002 Apr;14(2):102-7. (2002) Abstract

Brewer RP, Parra A, Lynch J, Chilukuri V, Borel CO. Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage.  J Neurosurg Anesthesiol.  2001 Jul;13(3):202-6. (2001) Abstract

Fabling JM, Gan TJ, El-Moalem HE, Warner DS, Borel CO. A randomized, double-blinded comparison of ondansetron, droperidol, and placebo for prevention of postoperative nausea and vomiting after supratentorial craniotomy.  Anesth Analg.  2000 Aug;91(2):358-61. (2000) Abstract

Bushnell CD, Phillips-Bute BG, Laskowitz DT, Lynch JR, Chilukuri V, Borel CO. Survival and outcome after endotracheal intubation for acute stroke. Neurology. 1999 Apr 22;52(7):1374-81. (1999) Abstract

Borel CO, Guy J, Barcik U, Natoli MJ, Vann RD. Effect of hypobaria on ventilatory and CO2 responses to short-term hypoxic exposure in cats. Respir Physiol. 1998 Jan;111(1):45-53. (1998) Abstract