Department / Division:
Medicine / Neurology

Address:
DUMC 2900
Durham, NC 27710

Appointment Telephone:
919-668-7600

Office Telephone:
919-668-5546

Fax Telephone:
919-684-6514

• MD, University of Western Ontario Schulich School of Medicine & Dentistry (Canada), 1985

• Internal Medicine, University of Western Ontario (Canada), 1986-1988
• Neurology, University of Western Ontario (Canada), 1988-1991

• Stroke Clinical Fellowship, University of Western Ontario (Canada), 1991
• Stroke Molecular Genetics, Duke University Medical Center, 1992-1994
• Vascular Neurology, University of Western Ontario; Duke University Medical Center, 1990-1991
• Neurosonology, Duke University Medical Center, 2005
• Neurocritical Care, University of Western Ontario, Duke University Medical Center, 1991-1994

• Fellow, Royal College of Physicians (Canada)
• Board Certifications, Neurology and Vascular Neurology

Clinical Interests:
Neurocritical care, stroke, acute care neurology

Research Interests:
As an neurointensivist with subspecialty training in cerebrovascular disease and neurocritical care my research focus is on the application of neurocritical care interventions to help patients with acute strokes and head injuries. My clinical research has focused on exploring methods to control body temperature in order to mitigate the detrimental effects of hyperthermia following acute neurological injury. Clinical trials utilizing novel intravascular thermoregulatory devices have demonstrated highly effective new methodoligies.

Current research studies include the use of therapeutic hypothermia to treat patients with acute traumatic brain injuries as well as following cardiac arrest. Out group at Duke is collaborating with other investigators to evolve the field of therapeutic hypothermia to be able to deliver this therapy in the field by EMS-paramedic personel.

Our research interests in intracerebral hemorrhage include the acute managment of hypertension, as well as the control of intracebral hypertension. We are collaborating in multiple NIH based studies involving patients with ICH.

Representative Publications:
Bushnell CD, Griffin J, Newby KL, Goldstein LB, Mahaffey KW, Graffagnino C, Harrington RA, White HD, Simes R J, Califf RM, Topol EJ., Easton JD. Statin Use and Sex-Specific Stroke Outcomes in Patients With Vascular Disease. Stroke. 2006; 37: 1427-1431. (2006)

Olson DM, Graffagnino C. Managing temperature in brain-injured patients. Nursing. Jul 2005;35(7):32cc31-32. (2005)

Neurocritical Care Fever Reduction Trial Group. Treatment of fever in the neurologic intensive care unit with a catheter-based heat exchange system. Critical Care Medicine. 2004; 32(2): 559-64. (2004)

Kassem-Moussa H, Mahaffey KW, Graffagnino C, Tasissa G, Sila CA, Simes RJ, White HD, Califf RM, Bhapkar MV, Newby LK, . Incidence and characteristics of stroke during 90-day follow-up in patients stabilized after an acute coronary syndrome. Am Heart J. 2004 Sep;148(3):439-46. (2004) Abstract

Al-Senani FM, Graffagnino C, Grotta JC, Saiki R, Wood D, Chung W, Palmer G, Collins KA. A prospective, multicenter pilot study to evaluate the feasibility and safety of using the CoolGard System and Icy catheter following cardiac arrest. Resuscitation. 2004 Aug;62(2):143-50. (2004) Abstract

Topol EJ, Easton D, Harrington RA, Amarenco P, Califf RM, Graffagnino C, Davis S, Diener HC, Ferguson J, Fitzgerald D, Granett J, Shuaib A, Koudstaal PJ, Theroux P, Van de Werf F, Sigmon K, Pieper K, Vallee M, Willerson JT, . Randomized, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease. Circulation. 2003 Jul 29;108(4):399-406. (2003) Abstract

McCarron MO, Weir CJ, Muir KW, Hoffmann KL, Graffagnino C, Nicoll JA, Lees KR, Alberts MJ. Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. Acta Neurol Scand. 2003 Feb;107(2):106-109. (2003) Abstract

Kassem-Moussa H, Graffagnino C. Nonocclusion and spontaneous recanalization rates in acute ischemic stroke: a review of cerebral angiography studies. Arch Neurol. 2002 Dec;59(12):1870-3. (2002) Abstract

Bulsara KR, Alexander MJ, Villavicencio AT, Graffagnino C. De novo cerebral arteriovenous malformation: case report. Neurosurgery. 2002 May;50(5):1137-40; discussion 1140-1. (2002) Abstract

Alberts MJ, McCarron MO, Hoffmann KL, Graffagnino C. Familial clustering of intracerebral hemorrhage: a prospective study in North Carolina. Neuroepidemiology. 2002 Jan-Feb;21(1):18-21. (2002) Abstract

Schwab S, Georgiadis D, Berrouschot J, Schellinger PD, Graffagnino C, Mayer SA. Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke. 2001 Sep;32(9):2033-5. (2001) Abstract

Topol EJ, Easton JD, Amarenco P, Califf R, Harrington R, Graffagnino C, Davis S, Diener HC, Ferguson J, Fitzgerald D, Shuaib A, Koudstaal PJ, Theroux P, Van de Werf F, Willerson JT, Chan R, Samuels R, Ilson B, Granett J. Design of the blockade of the glycoprotein IIb/IIIa receptor to avoid vascular occlusion (BRAVO) trial. Am Heart J. 2000 Jun;139(6):927-33. (2000) Abstract

Harrington RA, Armstrong PW, Graffagnino C, Van De Werf F, Kereiakes DJ, Sigmon KN, Card T, Joseph DM, Samuels R, Granett J, Chan R, Califf RM, Topol EJ. Dose-finding, safety, and tolerability study of an oral platelet glycoprotein IIb/IIIa inhibitor, lotrafiban, in patients with coronary or cerebral atherosclerotic disease. Circulation. 2000 Aug 15;102(7):728-35. (2000) Abstract

Mahaffey KW, Harrington RA, Simoons ML, Granger CB, Graffagnino C, Alberts MJ, Laskowitz DT, Miller JM, Sloan MA, Berdan LG, MacAulay CM, Lincoff AM, Deckers J, Topol EJ, Califf RM. Stroke in patients with acute coronary syndromes: incidence and outcomes in the platelet glycoprotein IIb/IIIa in unstable angina. Receptor suppression using integrilin therapy (PURSUIT) trial. The PURSUIT Investigators. Circulation. 1999 May 11;99(18):2371-7. (1999) Abstract

Gasecki AP, Graffagnino C, Hachinski V. Tissue plasminogen activator in a vertebral artery dissection. Can J Neurol Sci. 1997 May;24(2):151-4. (1997) Abstract

Alberts MJ, Davis JP, Graffagnino C, McClenny C, Delong D, Granger C, Herbstreith MH, Boteva K, Marchuk DA, Roses AD. Endoglin gene polymorphism as a risk factor for sporadic intracerebral hemorrhage. Ann Neurol. 1997 May;41(5):683-6. (1997) Abstract

Hachinski V, Graffagnino C, Beaudry M, Bernier G, Buck C, Donner A, Spence JD, Doig G, Wolfe BM. Lipids and stroke: a paradox resolved. Arch Neurol. 1996 Apr;53(4):303-8. (1996) Abstract

Graffagnino C, Herbstreith MH, Schmechel DE, Levy E, Roses AD, Alberts MJ. Cystatin C mutation in an elderly man with sporadic amyloid angiopathy and intracerebral hemorrhage. Stroke. 1995 Nov;26(11):2190-3. (1995) Abstract

Alberts MJ, Quinones A, Graffagnino C, Friedman A, Roses AD. Risk of intracranial aneurysms in families with subarachnoid hemorrhage. Can J Neurol Sci. 1995 May;22(2):121-5. (1995) Abstract

Alberts MJ, Graffagnino C, McClenny C, DeLong D, Strittmatter W, Saunders AM, Roses AD. ApoE genotype and survival from intracerebral haemorrhage. Lancet. 1995 Aug 26;346(8974):575. (1995) Abstract

Graffagnino C, Herbstreith MH, Roses AD, Alberts MJ. A molecular genetic study of intracerebral hemorrhage. Arch Neurol. 1994 Oct;51(10):981-4. (1994) Abstract

Graffagnino C, Gasecki AP, Doig GS, Hachinski VC. The importance of family history in cerebrovascular disease. Stroke. 1994 Aug;25(8):1599-604. (1994) Abstract

Graffagnino C, Alberts MJ. Restriction fragment length polymorphism of the apoprotein A-I-C-III gene cluster in control and stroke-prone white and black subjects: racial differences. Stroke. 1993 Jun;24(6):909-10. (1993) Abstract

Alberts MJ, Graffagnino C. Ulcerated plaques in the aortic arch in patients with stroke. N Engl J Med. 1992 Jul 9;327(2):128-9. (1992) Abstract