Physicians

Department / Division
Medicine / Medicine - Oncology

Address
DUMC 3872
Durham, NC 27710

Appointment Telephone
919-684-8964

Office Telephone
919-684-8964

Fax Telephone
919-684-5325

Training

• MD, University of Texas Southwestern Medical School, 1985

Residency

• Internal Medicine, Parkland Memorial Hospital (Texas), 1985-1988

Fellowship

• Hematology/Oncology, Duke University Medical Center, 1988-1991

Clinical Interests
Hematopoietic disorders, acute leukemia, myelodysplastic syndromes, aplastic anemia, myeloproliferative disorders, anemia, general hematology and oncology, paroxysmal nocturnal hemoglobinuria

Research Interests
Clinical research projects have focused on new and innovative treatments for myelodysplastic syndromes, paroxysmal nocturnal hemoglobinuria, adult leukemias, and lymphomas

Industry Relationships and Collaborations (What's this?)

This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Alexion Pharmaceuticals, Inc.

Representative Publications
He J, de Castro CM, Vandenbark GR, Busciglio J, Gabuzda D. Astrocyte Apoptosis Induced by HIV-1 Transactivation of the c-kit proto-oncogene. Proc Natl Acad Sci USA 94: 3954-3959, 1997. (1997)

Mann KP, de Castro CM, Liu J, Moore JO, Bigner S, Traweek ST. Neural cell adhesion molecule (CD56) positive acute myelogenous leukemia and myelodysplastic syndrome. Am J Clin Pathol 107: 653-660, 1997. 9. Wuebbens MW, Roush ED, de Castro CM, Fierke CA. Cloning, Sequencing, and Recombinant Expression of the Porcine Inhibitor of Carbonic Anhydrase: A Novel Member of the Transferrin Family. Biochemistry 36: 4327-4336, 1997. (1997)

de Castro CM, Rabe SM, Langdon SD, Fleenor DE, Ahmed MN, Qumsiyeh MB, Kaufman RE. Genomic Structure and Chromosomal Localization of PE-2 (ERF), a novel ETS Factor with Potential Tumor Suppressor Properties. Genomics 42: 227-235, 1997. (1997)

Vandenbark GR, Chen Y, Friday E, Pavlik K, Anthony B, de Castro C, Kaufman RE. Complex Regulation of Human c-kit Transcription by Promoter Repressors, Activators, and Specific myb Elements. Cell Growth Different 7:1383-1392, 1996. 6. Fleenor DE, Langdon SD, de Castro CM, Kaufman RE. Comparison of human and Xenopus GATA-2 promoters. Gene 179: 219-223, 1996. (1996)

de Castro CM, Devlin BH, Lee ME, Fleenor DE, Kaufman RE. A Novel b-globin Mutation, b Durham, N.C. [b 114 Leu-Pro], Detected by PCR-SSCP, Produces a Dominant Thalassemia-like Phenotype. Blood 83:1109-1116. 1994. (1994)

de Castro CM, Vandenbark GR, Langdon S, Denning SM, Kurtzberg J, Scearce R, Haynes BF, Kaufman RE. The Kit Proto-oncogene Receptor is Expressed on a Subset of Human CD3-, CD4-, CD8- (Triple Negative) Thymocytes. Exp Hematol 22:1025-1033, 1994. (1994)

Bowen DT, Padua RA, Burnett AK, de Castro CM, Kaufman RE. Two new polymorphisms but no mutations of the kit gene in patients with myelodysplasia at positions corresponding to human fms and murine W locus mutational hot spots. Leukemia 7:1883-1885, 1993. (1993)

Vandenbark GR, de Castro CM, Taylor H, Dew-Knight S, Kaufman RE. Cloning and structural analysis of the human c-kit gene. Oncogene 7:1259-1266, 1992. (1992)