Physicians

Department / Division
Radiation Oncology / Radiation Onc-Clinical Sup

Address
DUMC 3085
Durham, NC 27710

Appointment Telephone
919-660-2100

Office Telephone
919-668-7336

Fax Telephone
919-668-7345

Training

• MD, Medical College of Georgia School of Medicine, 1996

Residency

• Radiation Oncology, Massachusetts General Hospital, 1997-2001

Clinical Interests
Radiation oncology, gastrointestinal radiation oncology including esophagus, stomach, pancreas, hepatobiliary, colon, rectum, and anus; phase 1 clinical trials

Research Interests
Listed in Best Doctors in America. Listed in Top Doctors in North Carolina. His research interests include gastrointestinal malignancies, including treatment and integration of novel systemic agents with radiation therapy in the treatment of esophageal, gastric, hepatobiliary, pancreatic, colorectal and anal malignancies; phase I/II clinical trials evaluating novel systemic/targeted agents in conjunction with radiation therapy; investigation and optimization of the treatment of gastrointestinal malignancies, with focus on the above tumor sites.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Abbott Laboratories
• Amgen, Inc.
• up to date

Representative Publications
Turley, RS; Czito, BG; Haney, JC; Tyler, DS; Mantyh, CR; Migaly, J. Intraoperative pelvic brachytherapy for treatment of locally advanced or recurrent colorectal cancer. Techniques in Coloproctology. 2013;17:95-100. (2013) Abstract

Hood, RC; Wu, QJ; McMahon, R; Czito, B; Willett, C. IMRT treatment of anal cancer with a scrotal shield. Medical Dosimetry. 2012;37:432-435. (2012) Abstract

Palta, M; Patel, P; Broadwater, G; Willett, C; Pepek, J; Tyler, D; Zafar, SY; Uronis, H; Hurwitz, H; White, R; Czito, B. Carcinoma of the ampulla of Vater: patterns of failure following resection and benefit of chemoradiotherapy. Annals of Surgical Oncology. 2012;19:1535-1540. (2012) Abstract

Papalezova, KT; Tyler, DS; Blazer, DG; Clary, BM; Czito, BG; Hurwitz, HI; Uronis, HE; Pappas, TN; Willett, CG; White, RR. Does preoperative therapy optimize outcomes in patients with resectable pancreatic cancer?. Journal of Surgical Oncology. 2012;106:111-118. (2012) Abstract

Zagar, TM; White, RR; Willett, CG; Tyler, DS; Papavassiliou, P; Papalezova, KT; Guy, CD; Broadwater, G; Clough, RW; Czito, BG. Resected pancreatic neuroendocrine tumors: patterns of failure and disease-related outcomes with or without radiotherapy. International Journal of Radiation: Oncology - Biology - Physics. 2012;83:1126-1131. (2012) Abstract

Czito, BG; Willett, CG. Beyond 5-fluorouracil: the emerging role of newer chemotherapeutics and targeted agents with radiation therapy. Seminars in Radiation Oncology. 2011;21:203-211. (2011) Abstract

Czito, BG; Willett, CG. Introduction: current controversies in rectal cancer. Seminars in Radiation Oncology. 2011;21:167-168. (2011) Abstract

Ghafoori, AP; Nelson, JW; Willett, CG; Chino, J; Tyler, DS; Hurwitz, HI; Uronis, HE; Morse, MA; Clough, RW; Czito, BG. Radiotherapy in the treatment of patients with unresectable extrahepatic cholangiocarcinoma. International Journal of Radiation: Oncology - Biology - Physics. 2011;81:654-659. (2011) Abstract

Meyer, J; Balch, G; Willett, C; Czito, B. Update on treatment advances in combined-modality therapy for anal and rectal carcinomas. Current Oncology Reports. 2011;13:177-185. (2011) Abstract

Palta, M; Willett, C; Czito, B. Role of radiation therapy in patients with resectable pancreatic cancer. Oncology. 2011;25:715-727. (2011) Abstract

Czito, BG; Willett, CG. Adjuvant radiation therapy for distal pancreatic cancer: is there a role?. Annals of Surgical Oncology. 2010;17:3082-3084. (2010) Abstract

Duda, DG; Willett, CG; Ancukiewicz, M; di Tomaso, E; Shah, M; Czito, BG; Bentley, R; Poleski, M; Lauwers, GY; Carroll, M; Tyler, D; Mantyh, C; Shellito, P; Clark, JW; Jain, RK. Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer. The Oncologist. 2010;15:577-583. (2010) Abstract

Higgins, KA; Willett, CG; Czito, BG. Nonoperative management of rectal cancer: current perspectives. Clinical colorectal cancer. 2010;9:83-88. (2010) Abstract

Meyer, J; Willett, C; Czito, B. Current and emerging treatment strategies for anal cancer. Current Oncology Reports. 2010;12:168-174. (2010) Abstract

Pepek, JM; Willett, CG; Czito, BG. Radiation therapy advances for treatment of anal cancer. Journal of the National Comprehensive Cancer Network : JNCCN. 2010;8:123-129. (2010) Abstract

Pepek, JM; Willett, CG; Wu, QJ; Yoo, S; Clough, RW; Czito, BG. Intensity-modulated radiation therapy for anal malignancies: a preliminary toxicity and disease outcomes analysis. International Journal of Radiation: Oncology - Biology - Physics. 2010;78:1413-1419. (2010) Abstract

Willett, CG; Duda, DG; Ancukiewicz, M; Shah, M; Czito, BG; Bentley, R; Poleski, M; Fujita, H; Lauwers, GY; Carroll, M; Tyler, D; Mantyh, C; Shellito, P; Chung, DC; Clark, JW; Jain, RK. A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer. The Oncologist. 2010;15:845-851. (2010) Abstract

Xu, L; Czito, BG; Willett, CG. Epigenetic markers in rectal cancer. Clinical Cancer Research. 2010;16:2699-2701. (2010) Abstract

Zagar, TM; Willett, CG; Czito, BG. Intensity-modulated radiation therapy for anal cancer: toxicity versus outcomes. Oncology. 2010;24:815-828. (2010) Abstract

Czito, B; Lordick, F. Accomplishments in 2008 in the adjuvant treatment of rectal cancer. Gastrointestinal Cancer Research. 2009;3:S8-S14. (2009) Abstract

Czito, BG; Pepek, JM; Meyer, JJ; Yoo, S; Willett, CG. Intensity-modulated radiation therapy for anal cancer. Oncology. 2009;23:1082-1089. (2009) Abstract

Czito, BG; Willett, CG. Current management of anal canal cancer. Current Oncology Reports. 2009;11:186-192. (2009) Abstract

Czito, BG; Willett, CG. In pursuit of progress: multimodality strategies will form the cornerstone of cure for esophageal cancer. Gastrointestinal Cancer Research. 2009;3:74-76. (2009) Abstract

Fuller, CD; Wang, SJ; Choi, M; Czito, BG; Cornell, J; Welzel, TM; McGlynn, KA; Luh, JY; Thomas, CR. Multimodality therapy for locoregional extrahepatic cholangiocarcinoma: a population-based analysis. Cancer. 2009;115:5175-5183. (2009) Abstract

Nelson, JW; Ghafoori, AP; Willett, CG; Tyler, DS; Pappas, TN; Clary, BM; Hurwitz, HI; Bendell, JC; Morse, MA; Clough, RW; Czito, BG. Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma. International Journal of Radiation: Oncology - Biology - Physics. 2009;73:148-153. (2009) Abstract

Willett, CG; Czito, BG. Chemoradiotherapy in gastrointestinal malignancies. Clinical Oncology. 2009;21:543-556. (2009) Abstract

Willett, CG; Duda, DG; di Tomaso, E; Boucher, Y; Ancukiewicz, M; Sahani, DV; Lahdenranta, J; Chung, DC; Fischman, AJ; Lauwers, GY; Shellito, P; Czito, BG; Wong, TZ; Paulson, E; Poleski, M; Vujaskovic, Z; Bentley, R; Chen, HX; Clark, JW; Jain, RK. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. Journal of Clinical Oncology. 2009;27:3020-3026. (2009) Abstract

Xu, L; Duda, DG; di Tomaso, E; Ancukiewicz, M; Chung, DC; Lauwers, GY; Samuel, R; Shellito, P; Czito, BG; Lin, PC; Poleski, M; Bentley, R; Clark, JW; Willett, CG; Jain, RK. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Research. 2009;69:7905-7910. (2009) Abstract

Czito, BG; Cohen, DP; Kelsey, CR; Lockhart, AC; Bendell, JC; Willett, CG; Petros, WP; D'Amico, TA; Truax, R; Hurwitz, HI. A phase I study of UFT/leucovorin, carboplatin, and paclitaxel in combination with external beam radiation therapy for advanced esophageal carcinoma. International Journal of Radiation: Oncology - Biology - Physics. 2008;70:1066-1072. (2008) Abstract

Czito, BG; Willett, CG. Thirty years of rectal cancer research: a brief history. Oncology. 2008;22:1441-1444. (2008) Abstract

Meyer, JJ; Czito, BG; Willett, CG. Intensity-modulated radiation therapy for gastrointestinal tumors. Current Oncology Reports. 2008;10:206-211. (2008) Abstract

Meyer, JJ; Willett, CG; Czito, BG. Emerging role of intensity-modulated radiation therapy in anorectal cancer. Expert Review of Anticancer Therapy: an essential contribution to decision making in cancer care. 2008;8:585-593. (2008) Abstract

Meyer, JJ; Willett, CG; Czito, BG. Is there a role for advanced radiation therapy technologies in the treatment of pancreatic adenocarcinoma?. Future Oncology. 2008;4:241-255. (2008) Abstract

Willett, CG; Czito, BG. Does adjuvant chemoradiation benefit patients who have undergone resection of pancreatic or periampullary cancer?. Nature Clinical Practice Gastroenterology and Hepatology. 2008;5:364-365. (2008) Abstract

Willett, CG; Czito, BG. Impact of time duration after neoadjuvant therapy to surgery on response and outcome in rectal cancer patients. Annals of Surgical Oncology. 2008;15:2636-2638. (2008) Abstract

Czito, BG; Bendell, JC; Willett, CG; Morse, MA; Blobe, GC; Tyler, DS; Thomas, J; Ludwig, KA; Mantyh, CR; Ashton, J; Yu, D; Hurwitz, HI. Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results. International Journal of Radiation: Oncology - Biology - Physics. 2007;68:472-478. (2007) Abstract

Czito, BG; Kelsey, CR; Hurwitz, HI; Willett, CG; Morse, MA; Blobe, GC; Fernando, NH; D'Amico, TA; Harpole, DH; Honeycutt, W; Yu, D; Bendell, JC. A Phase I study of capecitabine, carboplatin, and paclitaxel with external beam radiation therapy for esophageal carcinoma. International Journal of Radiation: Oncology - Biology - Physics. 2007;67:1002-1007. (2007) Abstract

Czito, BG; Willett, CG. Commentary: rectal cancer an evolution of treatment. The Oncologist. 2007;12:1319-1320. (2007) Abstract

Czito, BG; Willett, CG. Contemporary management of rectal cancer: new standards, mounting questions, emerging challenges. Gastrointestinal Cancer Research. 2007;1:66-67. (2007) Abstract

Czito, BG; Willett, CG; Bendell, JC. Combined-modality therapy for rectal cancer: future prospects. Clinical Colorectal Cancer. 2007;6:625-633. (2007) Abstract

Kelsey, CR; Chino, JP; Willett, CG; Clough, RW; Hurwitz, HI; Morse, MA; Bendell, JC; D'Amico, TA; Czito, BG. Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer. International Journal of Radiation: Oncology - Biology - Physics. 2007;69:770-776. (2007) Abstract

Kelsey, CR; Nelson, JW; Willett, CG; Chino, JP; Clough, RW; Bendell, JC; Tyler, DS; Hurwitz, HI; Morse, MA; Clary, BM; Pappas, TN; Czito, BG. Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy. International Journal of Radiation: Oncology - Biology - Physics. 2007;69:1436-1441. (2007) Abstract

Meyer, J; Czito, B; Yin, FF; Willett, C. Advanced radiation therapy technologies in the treatment of rectal and anal cancer: intensity-modulated photon therapy and proton therapy. Clinical Colorectal Cancer. 2007;6:348-356. (2007) Abstract

Meyer, JJ; Czito, BG; Willett, CG. Particle radiation therapy for gastrointestinal malignancies. Gastrointestinal Cancer Research. 2007;1:S50-S59. (2007) Abstract

Willett, CG; Czito, BG; Bendell, JC. Adjuvant therapy of pancreatic cancer. The Cancer Journal. 2007;13:185-191. (2007) Abstract

Willett, CG; Czito, BG; Bendell, JC. Radiation therapy in stage II and III rectal cancer. Clinical Cancer Research. 2007;13:6903s-6908s. (2007) Abstract

Willett, CG; Czito, BG; Tyler, DS. Intraoperative radiation therapy. Journal of Clinical Oncology. 2007;25:971-977. (2007) Abstract

Willett, CG; Duda, DG; Czito, BG; Bendell, JC; Clark, JW; Jain, RK. Targeted therapy in rectal cancer. Oncology. 2007;21:1055-1065. (2007) Abstract

Willett, CG; Duda, DG; di Tomaso, E; Boucher, Y; Czito, BG; Vujaskovic, Z; Vlahovic, G; Bendell, J; Cohen, KS; Hurwitz, HI; Bentley, R; Lauwers, GY; Poleski, M; Wong, TZ; Paulson, E; Ludwig, KA; Jain, RK. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nature Clinical Practice Oncology. 2007;4:316-321. (2007) Abstract

Czito, BG; Anscher, MS; Willett, CG. Radiation therapy in the treatment of cholangiocarcinoma. Oncology. 2006;20:873-884. (2006) Abstract

Czito, BG; Bendell, J; Willett, CG. Radiation therapy for resectable colon cancer. Is there a role in the modern chemotherapy era?. Oncology. 2006;20:179-187. (2006) Abstract

Czito, BG; Hong, TJ; Cohen, DP; Petros, WP; Tyler, DS; Pappas, TN; Yu, D; Lee, CG; Lockhart, AC; Morse, MA; Fernando, N; Hurwitz, HI. A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract. Cancer Investigation. 2006;24:9-17. (2006) Abstract

Czito, BG; Willett, CG; Bendell, JC; Morse, MA; Tyler, DS; Fernando, NH; Mantyh, CR; Blobe, GC; Honeycutt, W; Yu, D; Clary, BM; Pappas, TN; Ludwig, KA; Hurwitz, HI. Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results. Journal of Clinical Oncology. 2006;24:656-662. (2006) Abstract