Physicians

Department / Division
Radiation Oncology / Radiation Onc-Clinical Sup

Address
DUMC 3085
Durham, NC 27710

Appointment Telephone
919-660-2100

Office Telephone
919-668-7336

Fax Telephone
919-668-7345

Training

• MD, Medical College of Georgia School of Medicine, 1996

Residency

• Radiation Oncology, Massachusetts General Hospital, 1997-2001

Clinical Interests
Radiation oncology, gastrointestinal radiation oncology including esophagus, stomach, pancreas, hepatobiliary, colon, rectum, and anus; phase 1 clinical trials

Research Interests
Listed in Best Doctors in America. Listed in Top Doctors in North Carolina. His research interests include gastrointestinal malignancies, including treatment and integration of novel systemic agents with radiation therapy in the treatment of esophageal, gastric, hepatobiliary, pancreatic, colorectal and anal malignancies; phase I/II clinical trials evaluating novel systemic/targeted agents in conjunction with radiation therapy; investigation and optimization of the treatment of gastrointestinal malignancies, with focus on the above tumor sites.

Industry Relationships and Collaborations (What's this?)

This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Amgen, Inc.
• Genentech, Inc (Roche Holding)
• OSI Pharmaceuticals, Inc
• UpToDate, Inc.

Representative Publications
Czito BG, Willett CG. Intraoperative Irradiation. In Gunderson LL, Tepper JE. Clinical Radiation Oncology, 3rd edition (in press). (2011)

Book “Rectal Cancer: International Perspectives on Multimodality Management” Czito BG, Willett CG, eds. Humana Press (2010)

Czito B, Donahue J, Willett C, et al. Retroperitoneal Sarcomas. In “ Intraoperative Irradiation - Techniques and Results” 2nd Edition. Eds LL Gunderson, CG Willett, FC Calvo and LB Harrison (in press) (2010)

Czito BG, Willett CG. Adjuvant Radiation Therapy for Distal Pancreatic Cancer: Is There a Role?  Ann Surg Oncol.  2010 Sep 29. (2010) Abstract

Czito BG, Willett CG. Colon Cancer. In Gunderson LL, Tepper JE. Clinical Radiation Oncology, 3rd edition (in press) (2010)

Czito BG, Willett CG. Gastrointestinal Radiation Injury. In Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 9th edition. Feldman M, Friedman L, Brandt L Editor, p 639-652
(2010)

Czito BG, Willett CG.  Radiation Injury to the Stomach. In Radiation Injury, 1st Edition.  Shrieve, D, Loeffler J. eds. Red Act Group p. 444-452 (2010)

Duda DG, Willett CG, Ancukiewicz M, di Tomaso E, Shah M, Czito BG, Bentley R, Poleski M, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Clark JW, Jain RK. Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer. Oncologist. 2010;15(6):577-83. (2010) Abstract

Ghafoori AP, Nelson JW, Willett CG, Chino J, Tyler DS, Hurwitz HI, Uronis HE, Morse MA, Clough RW, Czito BG. Radiotherapy in the Treatment of Patients with Unresectable Extrahepatic Cholangiocarcinoma. Int J Radiat Oncol Biol Phys. 2010 Sep 22. (2010) Abstract

Higgins KA, Willett CG, Czito BG. Nonoperative management of rectal cancer: current perspectives. Clin Colorectal Cancer. 2010 Apr;9(2):83-8. (2010) Abstract

Meyer J, Willett C, Czito B. Current and emerging treatment strategies for anal cancer. Curr Oncol Rep. 2010 May;12(3):168-74. (2010) Abstract

Pepek JM, Willett CG, Czito BG. Radiation therapy advances for treatment of anal cancer. J Natl Compr Canc Netw. 2010 Jan;8(1):123-9. (2010) Abstract

Pepek JM, Willett CG, Wu QJ, Yoo S, Clough RW, Czito BG. Intensity-Modulated Radiation Therapy for Anal Malignancies: A Preliminary Toxicity and Disease Outcomes Analysis.  Int J Radiat Oncol Biol Phys.  2010 Dec 1;78(5): 1413-9 (2010) Abstract

Willett CG, Czito BG. Neoadjuvant treatment of rectal cancer. In Radiation Medicine Rounds. Lower Gastrointestinal Malignancies. Eds. Ben-Josef E, Koong A. Demos Medical p 261-278 (2010)

Willett CG, Czito BG. Radiation Injury to the Pancreas. In Radiation Injury, 1st Edition.  Shrieve, D, Loeffler J. Eds. Red Act Group p 441-443 (2010)

Willett CG, Duda DG, Ancukiewicz M, Shah M, Czito BG, Bentley R, Poleski M, Fujita H, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Chung DC, Clark JW, Jain RK. A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer. Oncologist. 2010;15(8):845-51. (2010) Abstract

Xu L, Czito BG, Willett CG. Epigenetic markers in rectal cancer. Clin Cancer Res. 2010 May 15;16(10):2699-701. (2010) Abstract

Zagar TM, Willett CG, Czito BG. Intensity-modulated radiation therapy for anal cancer: toxicity versus outcomes. Oncology (Williston Park). 2010 Aug;24(9):815-23, 828. (2010) Abstract

Czito B, Lordick F. Accomplishments in 2008 in the adjuvant treatment of rectal cancer. Gastrointest Cancer Res. 2009 Sep;3(5 Supplement 2):S8-S14. (2009) Abstract

Czito B. Role of Radiation Therapy in Metastatic Rectal Cancer. Proceedings of Gastrointestinal Cancers Symposium. Educational Summary pg. 54-55, 2009. (2009)

Czito BG, Pepek JM, Meyer JJ, Yoo S, Willett CG. Intensity-modulated radiation therapy for anal cancer. Oncology (Williston Park). 2009 Nov 15;23(12):1082-9. (2009) Abstract

Czito BG, Willett CG. Current management of anal canal cancer. Curr Oncol Rep. 2009 May;11(3):186-92. (2009) Abstract

Czito BG, Willett CG. E updates: Controversies in the management of rectal cancer Are 3-D or IMRT radiation techniques helpful? Cancer network.com continuing medical education (2009)

Czito BG, Willett CG. In pursuit of progress: multimodality strategies will form the cornerstone of cure for esophageal cancer. Gastrointest Cancer Res. 2009 Mar;3(2):74-6. (2009) Abstract

Fuller CD, Wang SJ, Choi M, Czito BG, Cornell J, Welzel TM, McGlynn KA, Luh JY, Thomas CR Jr. Multimodality therapy for locoregional extrahepatic cholangiocarcinoma: a population-based analysis. Cancer. 2009 Nov 15;115(22):5175-83. (2009) Abstract

Nelson JW, Ghafoori AP, Willett CG, Tyler DS, Pappas TN, Clary BM, Hurwitz HI, Bendell JC, Morse MA, Clough RW, Czito BG. Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma. Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):148-53. (2009) Abstract

Willett CG, Czito BG, Bendell J Pancreatic Cancer. In Hafty BG, Wilson LD, Eds. Handbook of Radiation Oncology: Basic Principles and Clinical Protocols. Jones and Bartlett, First Edition, p 463-480. (2009)

Willett CG, Czito BG. Chemoradiotherapy in gastrointestinal malignancies. Clin Oncol (R Coll Radiol). 2009 Sep;21(7):543-56. (2009) Abstract

Willett CG, Czito BG. Combined Modality Therapy of Esophageal Cancer. ASCO Educational Book 2009.
(2009)

Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol. 2009 Jun 20;27(18):3020-6. (2009) Abstract

Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res. 2009 Oct 15;69(20):7905-10. (2009) Abstract

Czito BG, Cohen DP, Kelsey CR, Lockhart AC, Bendell JC, Willett CG, Petros WP, D'Amico TA, Truax R, Hurwitz HI. A Phase I Study of UFT/Leucovorin, Carboplatin, and Paclitaxel in Combination With External Beam Radiation Therapy for Advanced Esophageal Carcinoma. Int J Radiat Oncol Biol Phys. 2008 Mar 15;70(4):1066-72. (2008) Abstract

Czito BG, DeNittis A, Willett CG. Cancer of the Esophagus. In Principles and Practice of Radiation Oncology. Perez C, Brady L, Halperin E, Eds; 5th Edition. Lippincott, Williams and Wilkins p1131-1153. (2008)

Czito BG, Fuller CD. Radiation therapy for Disease of the Biliary Tree and Gall bladder.  In Biliary Tract and Gallbladder Cancer: Diagnosis and Therapy. Thomas CR, Fuller CD, Eds. 1st Edition. p 217-236 (2008)

Czito BG, Meyer JJ, Willett CG. Gastrointestinal toxicity of radiation therapy-parts I and II. In Up-to-date online reviews. (2008)

Czito BG, Willett CG. Thirty years of rectal cancer research: a brief history. Oncology (Williston Park). 2008 Nov 15;22(12):1441-2, 1444. (2008) Abstract

Meyer JJ, Czito BG, Willett CG. Intensity-modulated radiation therapy for gastrointestinal tumors. Curr Oncol Rep. 2008 May;10(3):206-11. (2008) Abstract

Meyer JJ, Willett CG, Czito BG. Emerging role of intensity-modulated radiation therapy in anorectal cancer. Expert Rev Anticancer Ther. 2008 Apr;8(4):585-93. (2008) Abstract

Meyer JJ, Willett CG, Czito BG. Is there a role for advanced radiation therapy technologies in the treatment of pancreatic adenocarcinoma? Future Oncol. 2008 Apr;4(2):241-55. (2008) Abstract

Mohiuddin M, Czito BG, Willett CG. Cancer of the Colon and Rectum. In Principles and Practice of Radiation Oncology. Perez C, Brady L, Halperin E, Eds; 5th Edition. Lippincott, Williams and Wilkins p1366-1382 (2008)

Petersen RP, Bendell J, Czito B, and Tyler DS.  Neoadjuvant therapy for resectable pancreatic cancer.  In: Pancreatic Cancer. 1st edition MD Anderson Solid Tumor Oncology Series. Lowy AM, Leach SD, and Philip PA., eds. Springer-Verlag. New York.  pp 549-562, 2008 (2008)

Willett C, Czito B. Neoadjuvant chemoradiation for rectal cancer.  Seminars in Colon and Rectal Surgery: Chemotherapy. 2008 Dec; 19:197-202. (2008)

Willett CG, Czito BG  “MTD Approach to Liver Metastases” in Jankowski J, Sampliner R, Kerr D and Fong Y. Gastrointestinal Oncology: A Critical Multidisciplinary Approach. p494-497. (2008)

Willett CG, Czito BG, C. Bendell JC. Cancer of the Pancreas. In Principles and Practice of Radiation Oncology. Perez C, Brady L, Halperin E, Eds; Fifth Edition Lippincott, Williams and Wilkins p1336-1348 (2008)

Willett CG, Czito BG. Does adjuvant chemoradiation benefit patients who have undergone resection of pancreatic or periampullary cancer? Nat Clin Pract Gastroenterol Hepatol. 2008 Jul;5(7):364-5. (2008) Abstract

Willett CG, Czito BG. Impact of time duration after neoadjuvant therapy to surgery on response and outcome in rectal cancer patients. Ann Surg Oncol. 2008 Oct;15(10):2636-8. (2008) Abstract

Czito BG, Bendell JC, Willett CG, Morse MA, Blobe GC, Tyler DS, Thomas J, Ludwig KA, Mantyh CR, Ashton J, Yu D, Hurwitz HI. Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results. Int J Radiat Oncol Biol Phys. 2007 Jun 1;68(2):472-8. (2007) Abstract

Czito BG, Kelsey CR, Hurwitz HI, Willett CG, Morse MA, Blobe GC, Fernando NH, D'Amico TA, Harpole DH, Honeycutt W, Yu D, Bendell JC. A Phase I study of capecitabine, carboplatin, and paclitaxel with external beam radiation therapy for esophageal carcinoma. Int J Radiat Oncol Biol Phys. 2007 Mar 15;67(4):1002-7. (2007) Abstract

Czito BG, Willett CG, Bendell JC. Combined-modality therapy for rectal cancer: future prospects. Clin Colorectal Cancer. 2007 Sep;6(9):625-33. (2007) Abstract

Czito BG, Willett CG. Commentary: rectal cancer an evolution of treatment. Oncologist. 2007 Nov;12(11):1319-20. (2007) Abstract

Czito BG, Willett CG. Contemporary management of rectal cancer: new standards, mounting questions, emerging challenges. Gastrointest Cancer Res. 2007 Mar;1(2):66-7. (2007) Abstract

Czito BG, Willett CG. Editorial "Contemporary Management of Rectal Cancer: New Standards, Mounting Questions, Emerging Challenges" Gastrointestinal Cancer Research 1: pg 66-67, 2007. (2007)

Czito BG, Willett CG. Rationale, design and results of clinical trials combining radiotherapy with antiangiogenic therapy in rectal cancer (Expert column) Medscape September 2007(Online) (2007)

Kelsey CR, Chino JP, Willett CG, Clough RW, Hurwitz HI, Morse MA, Bendell JC, D'Amico TA, Czito BG. Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer. Int J Radiat Oncol Biol Phys. 2007 Nov 1;69(3):770-6. (2007) Abstract

Kelsey CR, Nelson JW, Willett CG, Chino JP, Clough RW, Bendell JC, Tyler DS, Hurwitz HI, Morse MA, Clary BM, Pappas TN, Czito BG. Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1436-41. (2007) Abstract

Meyer J, Czito B, Yin FF, Willett C. Advanced radiation therapy technologies in the treatment of rectal and anal cancer: intensity-modulated photon therapy and proton therapy. Clin Colorectal Cancer. 2007 Jan;6(5):348-56. (2007) Abstract

Meyer JJ, Czito BG, Willett CG. Particle radiation therapy for gastrointestinal malignancies. Gastrointest Cancer Res. 2007;1(4 Suppl 2):S50-9. (2007) Abstract

Meyer JM, Czito BG, Willett CG. Particle radiotherapy for gastrointestinal malignancies. Gastrointestinal Cancer Research 2007; 1 (suppl 2): S54-S63. (2007)

Willett CG, Czito BG, Bendell JC. Adjuvant therapy of pancreatic cancer. Cancer J. 2007 May-Jun;13(3):185-91. (2007) Abstract

Willett CG, Czito BG, Bendell JC. Radiation therapy in stage II and III rectal cancer. Clin Cancer Res. 2007 Nov 15;13(22 Pt 2):6903s-8s. (2007) Abstract

Willett CG, Czito BG, Tyler DS. Intraoperative radiation therapy. J Clin Oncol. 2007 Mar 10;25(8):971-7. (2007) Abstract

Willett CG, Duda DG, Czito BG, Bendell JC, Clark JW, Jain RK. Targeted therapy in rectal cancer. Oncology (Williston Park). 2007 Aug;21(9):1055-65; discussion 1065, 1070, 1075 passim. (2007) Abstract

Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, Ludwig KA, Jain RK. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nat Clin Pract Oncol. 2007 May;4(5):316-21. (2007) Abstract

Czito BG  “Prevention of Radiation Proctitis”. In UpToDate online reviews May 2006. (2006)

Czito BG, Anscher MA. Radiation Therapy for Disease of the Biliary Tree and Gallbladder. In Clavien PA, Baillie J. Diseases of the Gallbladder and Bile Ducts, 2nd edition, Blackwell Publishing; p147-162 (2006). (2006)

Czito BG, Anscher MS, Willett CG. Radiation therapy in the treatment of cholangiocarcinoma. Oncology (Williston Park). 2006 Jul;20(8):873-84; discussion 886-8, 893-5. (2006) Abstract

Czito BG, Bendell J, Willett CG. Radiation therapy for resectable colon cancer. Is there a role in the modern chemotherapy era? Oncology (Williston Park). 2006 Feb;20(2):179-87; discussion 187-8, 192. (2006) Abstract

Czito BG, Hong TJ, Cohen DP, Petros WP, Tyler DS, Pappas TN, Yu D, Lee CG, Lockhart AC, Morse MA, Fernando N, Hurwitz HI. A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract. Cancer Invest. 2006 Feb;24(1):9-17. (2006) Abstract

Czito BG, Siddidi NH, Mamon HJ, et al. Gastrointestinal Brachytherapy. In Devlin P. Brachytherapy: Applications and Techniques, 1st edition, Lippincott, Williams and Wilkins p159-180 (2006). (2006)

Czito BG, Willett CG, Bendell JC, Morse MA, Tyler DS, Fernando NH, Mantyh CR, Blobe GC, Honeycutt W, Yu D, Clary BM, Pappas TN, Ludwig KA, Hurwitz HI. Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results. J Clin Oncol. 2006 Feb 1;24(4):656-62. (2006) Abstract

Czito BG, Willett CG. Colon Cancer. In Gunderson LL, Tepper JE. Clinical Radiation Oncology, 2nd edition Chapter 47, p 1101-1111 (2006). (2006)

Czito BG, Willett CG. Intraoperative Irradiation. In Gunderson LL, Tepper JE. Clinical Radiation Oncology, 2nd edition, Chapter 15, p 315-329 (2006) (2006)