Brad J. Kolls, MD, PhD, MMCi
Department / Division
Medicine /
Medicine-Neurology
Address
DUMC 2900
Durham, NC 27710
Appointment Telephone
Not accepting patients
Office Telephone
919-684-0084
Fax Telephone
919-684-6514
- MD, University of California–Irvine, School of Medicine, 2001
- Neurology, Duke University Medical Center, 2001-2005
- Neurocritical Care and Stroke, Duke University Medical Center, 2005-2007
- PhD, Neuroscience, University of California–Irvine, 1999
- MMCi, Master of Management and Clinical Informatics, Duke Fuqua School of Business, 2011
Clinical Interests
Neurologic critical care and multimodal monitoring; research interests include development of mouse-based models of post-traumatic epilepsy and brain monitoring in the ICU
Research Interests
As a neurointensivist, I am interested in improving our ability to monitor brain function and impact of therapy on our patients in the critical care setting. To this end I am developing new approaches to patient monitoring that will integrate patient physiologic monitoring with brain activity recorded by electroencephalography (EEG). On the basic science side I am interested in the central nervous system's response to injury. Although much attention has been focused on closed head injury as of late, stroke and brain hemorrhage are just as common in the civilian population and pose many of the same clinical challenges as traumatic brain injury. Using mouse models of clinically relevant brain injury, including models of stroke, subarachnoid hemorrhage, lobar hemorrhage, closed head injury and penetrating brain injury, we can explore the key molecular events that lead to edema, secondary brain injury, hyperexcitability and epilepsy, and other sequelae which contribute to poor patient recovery, and significant morbidity following brain injury. By investigating the underlying mechanisms that contribute to these adaptive changes using electrophysiology and molecular biology approaches we can then find ways to prevent them from becoming maladaptive and develop new therapies for our patients with head injuries.
This faculty member has no reported relationships with industry.
