Chief, Division of Gastroenterology
Department / Division
Medicine / Medicine - Gastroenterology
Durham, NC 27710
Liver disease, especially chronic metabolic liver diseases
Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).
Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.
Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.
This faculty member has no reported relationships with industry.
Jung, Y; Brown, KD; Witek, RP; Omenetti, A; Yang, L; Vandongen, M; Milton, RJ; Hines, IN; Rippe, RA; Spahr, L; Rubbia-Brandt, L; Diehl, AM. Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. Gastroenterology. 2008;134:1532-1543. (2008) Abstract
Omenetti, A; Diehl, AM. The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2008;294:G595-G598. (2008) Abstract
Omenetti, A; Popov, Y; Jung, Y; Choi, SS; Witek, RP; Yang, L; Brown, KD; Schuppan, D; Diehl, AM. The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Gut. 2008;57:1275-1282. (2008) Abstract
Ouyang, X; Cirillo, P; Sautin, Y; McCall, S; Bruchette, JL; Diehl, AM; Johnson, RJ; Abdelmalek, MF. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. Journal of Hepatology. 2008;48:993-999. (2008) Abstract
Solga, SF; Horska, A; Hemker, S; Crawford, S; Diggs, C; Diehl, AM; Brancati, FL; Clark, JM. Hepatic fat and adenosine triphosphate measurement in overweight and obese adults using 1H and 31P magnetic resonance spectroscopy. Liver International. 2008;28:675-681. (2008) Abstract
Yamaguchi, K; Yang, L; McCall, S; Huang, J; Yu, XX; Pandey, SK; Bhanot, S; Monia, BP; Li, YX; Diehl, AM. Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. Hepatology. 2008;47:625-635. (2008) Abstract
Yang, L; Jung, Y; Omenetti, A; Witek, RP; Choi, S; Vandongen, HM; Huang, J; Alpini, GD; Diehl, AM. Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells. 2008;26:2104-2113. (2008) Abstract
Yang, L; Wang, Y; Mao, H; Fleig, S; Omenetti, A; Brown, KD; Sicklick, JK; Li, YX; Diehl, AM. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. Journal of Hepatology. 2008;48:98-106. (2008) Abstract
Abdelmalek, MF; Diehl, AM. De novo nonalcoholic fatty liver disease after liver transplantation. Liver Transplantation. 2007;13:788-790. (2007) Abstract
Fleig, SV; Choi, SS; Yang, L; Jung, Y; Omenetti, A; VanDongen, HM; Huang, J; Sicklick, JK; Diehl, AM. Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. Laboratory Investigation. 2007;87:1227-1239. (2007) Abstract
Jung, Y; McCall, SJ; Li, YX; Diehl, AM. Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis. Hepatology. 2007;45:1091-1096. (2007) Abstract
Li, YX; Yang, HT; Zdanowicz, M; Sicklick, JK; Qi, Y; Camp, TJ; Diehl, AM. Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling. Laboratory Investigation. 2007;87:231-240. (2007) Abstract
Yamaguchi, K; Yang, L; McCall, S; Huang, J; Yu, XX; Pandey, SK; Bhanot, S; Monia, BP; Li, YX; Diehl, AM. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology. 2007;45:1366-1374. (2007) Abstract
Setji, TL; Holland, ND; Sanders, LL; Pereira, KC; Diehl, AM; Brown, AJ. Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism. 2006;91:1741-1747. (2006) Abstract
Sicklick, JK; Choi, SS; Bustamante, M; McCall, SJ; Pérez, EH; Huang, J; Li, YX; Rojkind, M; Diehl, AM. Evidence for epithelial-mesenchymal transitions in adult liver cells. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2006;291:G575-G583. (2006) Abstract
Zhao, C; Chen, W; Yang, L; Chen, L; Stimpson, SA; Diehl, AM. PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. Biochemical and Biophysical Research Communications. 2006;350:385-391. (2006) Abstract