Department / Division:
Anesthesiology

Address:
DUMC 3094
Durham, NC 27710

Office Telephone:
919-681-6752

• MD, St Bartholomew's Hospital Medical College, University of London (United Kingdom), 1992

• Anesthesia, Royal Postgraduate Medical School (United Kingdom), 1992-1998

• Cardiac Anesthesia and Critical Care Medicine, Royal Brompton and Harefield Hospital (United Kingdom), 1998-2000

• Fellow, Royal College of Anaesthetists (United Kingdom), 1996

Clinical Interests:
Anesthesia for cardiothoracic surgery

Research Interests:
I am interested in the genetics of perioperative medicine, particularly the role of genetic variation in the response to cardiothoracic surgery, and in postoperative acute renal failure. I am also coordinating a world wide biorepository of genetic material in patients undergoing cardiothoracic surgery - iPEGASUS, the international Perioperative Genetics and Safety Outcome Study.

My clinical practice is anesthesia and intensive care - perioperative medicine - for cardiothoracic surgical patients, including heart and lung transplantation, lung and esophageal cancer resection and ventricular assist device placement.

Representative Publications:
Aravindan N, Natarajan M, Shaw AD. Fenoldopam inhibits nuclear translocation of nuclear factor kappa B in a rat model of surgical ischemic acute renal failure. J Cardiothorac Vasc Anesth. 2006 Apr;20(2):179-86. (2006) Abstract

Aravindan N, Cata JP, Dougherty PM, Shaw AD. Effect of fenoldopam on ischemia/reperfusion-induced apoptosis. Ren Fail. 2006;28(4):337-44. (2006) Abstract

Weng HR, Aravindan N, Cata JP, Chen JH, Shaw AD, Dougherty PM. Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia. Neurosci Lett. 2005 Sep 23;386(1):18-22. (2005) Abstract

Tumlin JA, Finkel KW, Murray PT, Samuels J, Cotsonis G, Shaw AD. Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial. Am J Kidney Dis. 2005 Jul;46(1):26-34. (2005) Abstract

Shaw AD, Vaporciyan AA, Wu X, King TM, Spitz MR, Putnam JB, Dickey BF. Inflammatory gene polymorphisms influence risk of postoperative morbidity after lung resection. Ann Thorac Surg. 2005 May;79(5):1704-10. (2005) Abstract

Martin CB, Shaw AD, Gal J, Aravindan N, Murphy F, Royston D, Riedel BJ. The comparison and validity of troponin I assay systems in diagnosing myocardial ischemic injury after surgical coronary revascularization. J Cardiothorac Vasc Anesth. 2005 Jun;19(3):288-93. (2005) Abstract

Aravindan N, Williams MT, Riedel BJ, Shaw AD. Transcriptional responses of rat skeletal muscle following hypoxia-reoxygenation and near ischaemia-reperfusion. Acta Physiol Scand. 2005 Apr;183(4):367-77. (2005) Abstract

Villars PS, Hamlin SK, Shaw AD, Kanusky JT. Role of diastole in left ventricular function, I: Biochemical and biomechanical events. Am J Crit Care. 2004 Sep;13(5):394-403; quiz 404-5. (2004) Abstract

Hamlin SK, Villars PS, Kanusky JT, Shaw AD. Role of diastole in left ventricular function, II: diagnosis and treatment. Am J Crit Care. 2004 Nov;13(6):453-66; quiz 467-8. (2004) Abstract

Williams MT, Aravindan N, Wallace MJ, Riedel BJ, Shaw AD. Venous thromboembolism in the intensive care unit. Crit Care Clin. 2003 Apr;19(2):185-207. (2003) Abstract

Shaw AD, Li Z, Thomas Z, Stevens CW. Assessment of tissue oxygen tension: comparison of dynamic fluorescence quenching and polarographic electrode technique. Crit Care. 2002 Feb;6(1):76-80. (2002) Abstract

Riedel BJ, Shaw AD. Thoracic epidural anesthesia & analgesia in patients undergoing coronary artery bypass surgery. Anesth Analg. 2002 May;94(5):1365; author reply 1366. (2002) Abstract

Mitchell JB, Shaw AD, Donald S, Farrimond JG. Differential lung ventilation after single-lung transplantation for emphysema. J Cardiothorac Vasc Anesth. 2002 Aug;16(4):459-62. (2002) Abstract

Kish Wallace S, Martin CG, Shaw AD, Price KJ. Influence of an advance directive on the initiation of life support technology in critically ill cancer patients. Crit Care Med. 2001 Dec;29(12):2294-8. (2001) Abstract

Weavind L, Shaw AD, Feeley TW. Monitoring ventilator weaning--predictors of success. J Clin Monit Comput. 2000;16(5-6):409-16. (2000) Abstract

Shaw AD, Boscoe MJ. Anaphylactic reaction following intravenous adenosine. Anaesthesia. 1999 Jun;54(6):608. (1999) Abstract

Shaw AD, Morgan M. Nitrous oxide: time to stop laughing? Anaesthesia. 1998 Mar;53(3):213-5. (1998) Abstract

Shaw AD, Mitchell JB. Anaesthesia for video-assisted thoracoscopic patent ductus arteriosus ligation. Anaesthesia. 1998 Sep;53(9):914-7. (1998) Abstract

Shaw AD, Chamberlain SK, Spased-Byrne SM, Lockwood GG. Nitrous oxide and carbon dioxide have no effect on the blood-gas solubilities of sevoflurane and isoflurane. Anesth Analg. 1998 Dec;87(6):1412-5. (1998) Abstract

Shaw AD, Baldock GJ. Continuous gastric tonometry as a monitor of intestinal perfusion. Anaesthesia. 1997 Jul;52(7):709-10. (1997) Abstract

Gaer JA, Shaw AD, Wild R, Swift RI, Munsch CM, Smith PL, Taylor KM. Effect of cardiopulmonary bypass on gastrointestinal perfusion and function. Ann Thorac Surg. 1994 Feb;57(2):371-5. (1994) Abstract