Physicians

Department / Division
Anesthesiology / Anesthesiology-Cardiac Division

Address
DUMC 3094
Durham, NC 27710

Office Telephone
919-286-6938

Fax Telephone
919-286-6853

Training

• MD, University of London Saint Bartholomew's Hospital Medical College, (United Kingdom), 1992

Residency

• Anesthesia, Royal Postgraduate Medical School (United Kingdom), 1992-1998

Fellowship

• Cardiac Anesthesia and Critical Care Medicine, Royal Brompton and Harefield Hospital (United Kingdom), 1998-2000

Other Training

• Fellow, Royal College of Anaesthetists (United Kingdom), 1996

Clinical Interests
Anesthesia for cardiothoracic surgery, surgical critical care

Research Interests
Dr Shaw is an Associate Professor of Anesthesiology and Critical Care Medicine at Duke University Medical Center. He is a Fellow of the Royal College of Anaesthetists (UK) and a Fellow of the American College of Critical Care Medicine. He has practiced cardiothoracic anesthesiology and critical care medicine for more than 15 years in the UK and USA, has authored 3 textbooks and more than 100 original papers. He currently runs the iPEGASUS initiative, an international surgical outcomes consortium focused on genetics and genomics in perioperative medicine. His clinical practice is cardiothoracic anesthesia and surgical critical care medicine. His translational research interests include the use of metabolomics, proteomics and genomics for biomarker discovery in acute illness and injury; his clinical research interests include observational and interventional trials of candidate interventions to prevent and treat adverse outcomes following surgery. His research is funded by the National Institutes of Health, the US Department of Defence, private philanthropy and by industry.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Astute Biomedical
• Baxter Healthcare
• Covidien
• FAST Biomedical
• Nonin Medical Inc.
• NxStage
• Thrasos

Representative Publications
Alge, JL; Karakala, N; Neely, BA; Janech, MG; Tumlin, JA; Chawla, LS; Shaw, AD; Arthur, JM; SAKInet Investigators. Urinary angiotensinogen and risk of severe AKI. Clinical Journal of the American Society of Nephrology. 2013;8:184-193. (2013) Abstract

Bain, CR; Shaw, AD. Genetics and epigenetics in perioperative medicine. Current Opinion in Critical Care. 2012;18:548-554. (2012) Abstract

Buchheit, T; Van de Ven, T; Shaw, A. Epigenetics and the transition from acute to chronic pain. Pain Medicine. 2012;13:1474-1490. (2012) Abstract

Man, M; Close, SL; Shaw, AD; Bernard, GR; Douglas, IS; Kaner, RJ; Payen, D; Vincent, JL; Fossceco, S; Janes, JM; Leishman, AG; O'Brien, L; Williams, MD; Garcia, JG. Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. Pharmacogenomics Journal. 2012; (2012) Abstract

Shaw, AD; Bagshaw, SM; Goldstein, SL; Scherer, LA; Duan, M; Schermer, CR; Kellum, JA. Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte. Annals of Surgery. 2012;255:821-829. (2012) Abstract

Willie, CK; Macleod, DB; Shaw, AD; Smith, KJ; Tzeng, YC; Eves, ND; Ikeda, K; Graham, J; Lewis, NC; Day, TA; Ainslie, PN. Regional brain blood flow in man during acute changes in arterial blood gases. The Journal of Physiology. 2012;590:3261-3275. (2012) Abstract

D'Alonzo, RC; Bennett-Guerrero, E; Podgoreanu, M; D'Amico, TA; Harpole, DH; Shaw, AD. A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery. Journal of Anesthesia. 2011;25:672-678. (2011) Abstract

Kaplan, LJ; Shaw, AD. Standards for education and credentialing in critical care medicine. JAMA: Journal of the American Medical Association. 2011;305:296-297. (2011) Abstract

Shaw, A. Models of preventable disease: contrast-induced nephropathy and cardiac surgery-associated acute kidney injury. Contributions to Nephrology. 2011;174:156-162. (2011) Abstract

Shaw, AD; Chalfin, DB; Kleintjens, J. The economic impact and cost-effectiveness of urinary neutrophil gelatinase-associated lipocalin after cardiac surgery. Clinical Therapeutics: the international peer-reviewed journal of drug therapy. 2011;33:1713-1725. (2011) Abstract

Shaw, AD; Vail, GM; Haney, DJ; Xie, J; Williams, MD. Severe protein C deficiency is associated with organ dysfunction in patients with severe sepsis. Journal of Critical Care. 2011;26:539-545. (2011) Abstract

Chaney, E; Shaw, A. Pathophysiology of fluid retention in heart failure. Contributions to Nephrology. 2010;164:46-53. (2010) Abstract

Ng, CS; Shaw, AD; Bell, CS; Samuels, JA. Effect of IV contrast medium on renal function in oncologic patients undergoing CT in ICU. American Journal of Roentgenology. 2010;195:414-422. (2010) Abstract

Shaw, A; VandeVen, T. Secrets of the perioptome: new tools for a new concept. Current Opinion in Critical Care. 2010;16:365-370. (2010) Abstract

Grichnik, KP; Shaw, A. Update on one-lung ventilation: the use of continuous positive airway pressure ventilation and positive end-expiratory pressure ventilation--clinical application. Current Opinion in Anaesthesiology. 2009;22:23-30. (2009) Abstract

Kociol, R; Rogers, J; Shaw, A. Organ cross talk in the critically ill: the heart and kidney. Blood Purification. 2009;27:311-320. (2009) Abstract

Nicoara, A; Patel, UD; Phillips-Bute, BG; Shaw, AD; Stafford-Smith, M; Milano, CA; Swaminathan, M. Mortality trends associated with acute renal failure requiring dialysis after CABG surgery in the United States. Blood Purification. 2009;28:359-363. (2009) Abstract

Conlon, NP; Shaw, AD; Grichnik, KP. Postthoracotomy paravertebral analgesia: will it replace epidural analgesia?. Anesthesiology Clinics. 2008;26:369-viii. (2008) Abstract

Shaw, A; Swaminathan, M; Stafford-Smith, M. Cardiac surgery-associated acute kidney injury: putting together the pieces of the puzzle. The Nephron Journals. 2008;109:p55-p60. (2008) Abstract

Shaw, AD; Stafford-Smith, M; White, WD; Phillips-Bute, B; Swaminathan, M; Milano, C; Welsby, IJ; Aronson, S; Mathew, JP; Peterson, ED; Newman, MF. The effect of aprotinin on outcome after coronary-artery bypass grafting. New England Journal of Medicine. 2008;358:784-793. (2008) Abstract

Shaw, A. Exploring the perioptome: the role of genomics in thoracic surgery and anaesthesia. Current Opinion in Anaesthesiology. 2007;20:32-36. (2007) Abstract

Aravindan, N; Cata, JP; Dougherty, PM; Shaw, AD. Effect of fenoldopam on ischemia/reperfusion-induced apoptosis. Renal Failure. 2006;28:337-344. (2006) Abstract

Aravindan, N; Natarajan, M; Shaw, AD. Fenoldopam inhibits nuclear translocation of nuclear factor kappa B in a rat model of surgical ischemic acute renal failure. Journal of Cardiothoracic and Vascular Anesthesia. 2006;20:179-186. (2006) Abstract

Aravindan, N; Williams, MT; Riedel, BJ; Shaw, AD. Transcriptional responses of rat skeletal muscle following hypoxia-reoxygenation and near ischaemia-reperfusion. Acta Physiologica. 2005;183:367-377. (2005) Abstract

Martin, CB; Shaw, AD; Gal, J; Aravindan, N; Murphy, F; Royston, D; Riedel, BJ. The comparison and validity of troponin I assay systems in diagnosing myocardial ischemic injury after surgical coronary revascularization. Journal of Cardiothoracic and Vascular Anesthesia. 2005;19:288-293. (2005) Abstract

Shaw, AD; Vaporciyan, AA; Wu, X; King, TM; Spitz, MR; Putnam, JB; Dickey, BF. Inflammatory gene polymorphisms influence risk of postoperative morbidity after lung resection. Annals of Thoracic Surgery. 2005;79:1704-1710. (2005) Abstract

Tumlin, JA; Finkel, KW; Murray, PT; Samuels, J; Cotsonis, G; Shaw, AD. Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial. American Journal of Kidney Diseases. 2005;46:26-34. (2005) Abstract

Weng, HR; Aravindan, N; Cata, JP; Chen, JH; Shaw, AD; Dougherty, PM. Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia. Neuroscience Letters. 2005;386:18-22. (2005) Abstract

Hamlin, SK; Villars, PS; Kanusky, JT; Shaw, AD. Role of diastole in left ventricular function, II: diagnosis and treatment. American Journal of Critical Care. 2004;13:453-466. (2004) Abstract

Villars, PS; Hamlin, SK; Shaw, AD; Kanusky, JT. Role of diastole in left ventricular function, I: Biochemical and biomechanical events. American Journal of Critical Care. 2004;13:394-403. (2004) Abstract

Williams, MT; Aravindan, N; Wallace, MJ; Riedel, BJ; Shaw, AD. Venous thromboembolism in the intensive care unit. Critical Care Clinics. 2003;19:185-207. (2003) Abstract

Mitchell, JB; Shaw, AD; Donald, S; Farrimond, JG. Differential lung ventilation after single-lung transplantation for emphysema. Journal of Cardiothoracic and Vascular Anesthesia. 2002;16:459-462. (2002) Abstract

Riedel, BJ; Shaw, AD. Thoracic epidural anesthesia & analgesia in patients undergoing coronary artery bypass surgery. Anesthesia and Analgesia. 2002;94:1365. (2002) Abstract

Shaw, AD; Li, Z; Thomas, Z; Stevens, CW. Assessment of tissue oxygen tension: comparison of dynamic fluorescence quenching and polarographic electrode technique. Critical Care (UK). 2002;6:76-80. (2002) Abstract

Kish Wallace, S; Martin, CG; Shaw, AD; Price, KJ. Influence of an advance directive on the initiation of life support technology in critically ill cancer patients. Critical Care Medicine. 2001;29:2294-2298. (2001) Abstract

Weavind, L; Shaw, AD; Feeley, TW. Monitoring ventilator weaning--predictors of success. Journal of Clinical Monitoring and Computing. 2000;16:409-416. (2000) Abstract

Shaw, AD; Boscoe, MJ. Anaphylactic reaction following intravenous adenosine. Anaesthesia. 1999;54:608. (1999) Abstract

Shaw, AD; Chamberlain, SK; Spased-Byrne, SM; Lockwood, GG. Nitrous oxide and carbon dioxide have no effect on the blood-gas solubilities of sevoflurane and isoflurane. Anesthesia and Analgesia. 1998;87:1412-1415. (1998) Abstract

Shaw, AD; Mitchell, JB. Anaesthesia for video-assisted thoracoscopic patent ductus arteriosus ligation. Anaesthesia. 1998;53:914-917. (1998) Abstract

Shaw, AD; Morgan, M. Nitrous oxide: time to stop laughing?. Anaesthesia. 1998;53:213-215. (1998) Abstract

Shaw, AD; Baldock, GJ. Continuous gastric tonometry as a monitor of intestinal perfusion. Anaesthesia. 1997;52:709-710. (1997) Abstract

Gaer, JA; Shaw, AD; Wild, R; Swift, RI; Munsch, CM; Smith, PL; Taylor, KM. Effect of cardiopulmonary bypass on gastrointestinal perfusion and function. Annals of Thoracic Surgery. 1994;57:371-375. (1994) Abstract