Rex C. Bentley, MD

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Services

• Breast Cancer
• Gynecologic Cancer

Department / Division:
Pathology / Pathology

Address:
DUMC 3712
Durham, NC 27710

Office Telephone:
(919) 684-6423

Fax Telephone:
(919) 681-7634

• M.D., Harvard School of Medicine, Massachusetts, 1986

• Pathology, Duke University Medical Center, North Carolina, 1986-1992

• Surgical Pathology, Duke University Medical Center, North Carolina, 1992-1993

Clinical Interests:
General surgical pathology, gynecologic pathology, obstetric pathology, electron microscopy of tumors, breast pathology

Research Interests:
Outcome-based research on pathology of endometrial carcinoma, including prognostic significance of histologic features of endometrial carcinoma, variants of endometrial carcinoma, definitions of atypia and well-differentiated carcinoma, and collaborative studies of oncogenes and tumor suppressor genes in endometrial carcinoma.  

Endometrial pathology, especially as it relates to molecular/genetic alterations in neoplasms.

Ovarian pathology, especially as it relates to molecular and genetic alterations in neoplasms.

Improving accuracy of radiographic screening for breast cancer, by careful patho-radiographic correlation and study of improved imaging techniques (especially ultrasound).

Use of electron microscopy as a diagnostic and research technique.

Representative Publications:
Kornguth PJ, Bentley RC:  Mammographic-pathologic correlation:  Part 2 malignant breast lesions.  Journal of Women's Imaging 3: 134-145 (2001). (2001)

Robboy SJ, Bentley RC, Russell P:  Pathology of Abnormal Sexual Development.  In Haines & Taylor's Gynaecological and Obstetrical Pathology. 5th Edition, Fox H, Wells M, eds. Churchill Livingstone, London. March, 2001. (2001)

Bentley R: Endometrial Hyperplasias and their distinction from adenocarcinomas. In Heller D, ed. The Endometrium: A Clinicopathological Approach. New York: Igaku-Shoin, 1994, pp. 114-136. (1994)

Zaino, R, Robboy S, Bentley R, Kurman R: Diseases of the Vagina. In Kurman RJ, ed. Blaustein's Pathology of the Female Genital Tract, 4th edition, New York: Springer-Verlag, 1994, pp. 131-184. (1994)

Bentley RC and Robboy SJ:  Interpretation of endometrial pathology with hormone replacement therapy in post-menpausal women.  In Studd J, ed.  The Management of the Menopause.  Parthenon, Pearl River, NY, 2000, pp. 255-266. (2000)

Bentley RC, Robboy SJ, Russell P, Anderson MC:  Exogenous Hormones and Endometrium. In:  Robboy SJ, Anderson M, Russell P:  Pathology of the Female Genital Tract, 4th Ed., Churchill Livingstone, London, 2002. (2002)

Kornguth PJ, Bentley RC:  Mammographic-Pathologic Correlation:  Part I, Benign Lesions.  Journal of Women's Imaging 3: 29-37, 2001. (2001)

White RR, Halperin TJ, Olson JA Jr, Soo MS, Bentley RC, Seigler HF. Impact of core-needle breast biopsy on the surgical management of mammographic abnormalities. Ann Surg. 2001 Jun;233(6):769-77. (2001) Abstract

Rodriguez GC, Nagarsheth NP, Lee KL, Bentley RC, Walmer DK, Cline M, Whitaker RS, Isner P, Berchuck A, Dodge RK, Hughes CL. Progestin-induced apoptosis in the Macaque ovarian epithelium: differential regulation of transforming growth factor-beta. J Natl Cancer Inst. 2002 Jan 2;94(1):50-60. (2002) Abstract

Stern RC, Dash R, Bentley RC, Snyder MJ, Haney AF, Robboy SJ. Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types. Int J Gynecol Pathol. 2001 Apr;20(2):133-9. (2001) Abstract

Alvarez AA, Moore WF, Robboy SJ, Bentley RC, Gumbs C, Futreal PA, Berchuck A. K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary. Gynecol Oncol. 2001 Feb;80(2):201-6. (2001) Abstract

Harris LN, Liotcheva V, Broadwater G, Ramirez MJ, Maimonis P, Anderson S, Everett T, Harpole D, Moore MB, Berry DA, Rizzeri D, Vredenburgh JJ, Bentley RC. Comparison of methods of measuring HER-2 in metastatic breast cancer patients treated with high-dose chemotherapy. J Clin Oncol. 2001 Mar 15;19(6):1698-706. (2001) Abstract

Rosen EL, Bentley RC, Baker JA, Soo MS. Imaging-guided core needle biopsy of papillary lesions of the breast. AJR Am J Roentgenol. 2002 Nov;179(5):1185-92. (2002) Abstract

Lancaster JM, Wenham RM, Halabi S, Calingaert B, Marks JR, Moorman PG, Bentley RC, Berchuck A, Schildkraut JM. No relationship between ovarian cancer risk and progesterone receptor gene polymorphism in a population-based, case-control study in North Carolina. Cancer Epidemiol Biomarkers Prev. 2003 Mar;12(3):226-7. (2003) Abstract

Bentley RC. Pathology of Gestational Trophoblastic Disease. Clin Obstet Gynecol. 2003 Sep;46(3):513-522. (2003) Abstract

Alvarez AA, Axelrod JR, Whitaker RS, Isner PD, Bentley RC, Dodge RK, Rodriguez GC. Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients. Gynecol Oncol. 2001 Aug;82(2):273-8. (2001) Abstract

Heinrich G, Gros P, Lund PK, Bentley RC, Habener JF. Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid. Endocrinology. 1984 Dec;115(6):2176-81. (1984) Abstract

Moore WF, Bentley RC, Berchuck A, Robboy SJ. Some mullerian inclusion cysts in lymph nodes may sometimes be metastases from serous borderline tumors of the ovary. Am J Surg Pathol. 2000 May;24(5):710-8. (2000) Abstract

Yelverton CL, Bentley RC, Olenick S, Krigman HR, Johnston WW, Robboy SJ. Epithelial repair of the uterine cervix: assessment of morphologic features and correlations with cytologic diagnosis. Int J Gynecol Pathol. 1996 Oct;15(4):338-44. (1996) Abstract

Bentley RC, Keene JD. Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein. Mol Cell Biol. 1991 Apr;11(4):1829-39. (1991) Abstract

Ibrahim SN, Krigman HR, Coogan AC, Wax TD, Dodd LG, Bentley RC, Robboy SJ, Johnston WW. Prospective correlation of cervicovaginal cytologic and histologic specimens. Am J Clin Pathol. 1996 Sep;106(3):319-24. (1996) Abstract

Maxwell GL, Risinger JI, Gumbs C, Shaw H, Bentley RC, Barrett JC, Berchuck A, Futreal PA. Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. Cancer Res. 1998 Jun 15;58(12):2500-3. (1998) Abstract

Cirisano FD Jr, Robboy SJ, Dodge RK, Bentley RC, Krigman HR, Synan IS, Soper JT, Clarke-Pearson DL. The outcome of stage I-II clinically and surgically staged papillary serous and clear cell endometrial cancers when compared with endometrioid carcinoma. Gynecol Oncol. 2000 Apr;77(1):55-65. (2000) Abstract

Anderson ME, Soo MS, Bentley RC, Trahey GE. The detection of breast microcalcifications with medical ultrasound. J Acoust Soc Am. 1997 Jan;101(1):29-39. (1997) Abstract

Usadi RS, Bentley RC. Endometrioid carcinoma of the endometrium with sertoliform differentiation. Int J Gynecol Pathol. 1995 Oct;14(4):360-4. (1995) Abstract

Mooney EE, Robboy SJ, Hammond CB, Berchuck A, Bentley RC. Signet-ring cell carcinoma of the endometrium: a primary tumor masquerading as a metastasis. Int J Gynecol Pathol. 1997 Apr;16(2):169-72. (1997) Abstract

Soo MS, Williford ME, Walsh R, Bentley RC, Kornguth PJ. Papillary carcinoma of the breast: imaging findings. AJR Am J Roentgenol. 1995 Feb;164(2):321-6. (1995) Abstract

Robboy SJ, Bentley RC, Butnor K, Anderson MC. Pathology and pathophysiology of uterine smooth-muscle tumors. Environ Health Perspect. 2000 Oct;108 Suppl 5:779-84. (2000) Abstract

Hansard LJ, Healy-Gardner BE, Drapkin AT, Bentley RC, McLachlan JA, Walmer DK. Human endometrial transforming growth factor-alpha: a transmembrane, surface epithelial protein that transiently disappears during the midsecretory phase of the menstrual cycle. J Soc Gynecol Investig. 1997 May-Jun;4(3):160-6. (1997) Abstract

Rosen EL, Soo MS, Bentley RC. Focal fibrosis: a common breast lesion diagnosed at imaging-guided core biopsy. AJR Am J Roentgenol. 1999 Dec;173(6):1657-62. (1999) Abstract

Soo MS, Dash N, Bentley R, Lee LH, Nathan G. Tubular adenomas of the breast: imaging findings with histologic correlation. AJR Am J Roentgenol. 2000 Mar;174(3):757-61. (2000) Abstract

Prade M, Spatz A, Bentley R, Duvillard P, Bognel C, Robboy SJ. Borderline and malignant serous tumor arising in pelvic lymph nodes: evidence of origin in benign glandular inclusions. Int J Gynecol Pathol. 1995 Jan;14(1):87-91. (1995) Abstract

Couchman GM, Bentley R, Tsao MS, Raszmann K, McLachlan JA, Walmer DK. p53lyn and p56lyn: a new signaling pathway in human endometrium and endometrial adenocarcinomas. J Soc Gynecol Investig. 1997 Mar-Apr;4(2):103-9. (1997) Abstract

Wenham RM, Calingaert B, Ali S, McClean K, Whitaker R, Bentley R, Lancaster JM, Schildkraut J, Marks J, Berchuck A. Matrix metalloproteinase-1 gene promoter polymorphism and risk of ovarian cancer. J Soc Gynecol Investig. 2003 Sep;10(6):381-7. (2003) Abstract

Lukes AS, Kohler MF, Pieper CF, Kerns BJ, Bentley R, Rodriguez GC, Soper JT, Clarke-Pearson DL, Bast RC Jr, Berchuck A. Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer. Cancer. 1994 May 1;73(9):2380-5. (1994) Abstract

Krigman H, Bentley R, Robboy SJ. Pathology of epithelial ovarian tumors. Clin Obstet Gynecol. 1994 Jun;37(2):475-91. (1994) Abstract

Cirisano FD Jr, Robboy SJ, Dodge RK, Bentley RC, Krigman HR, Synan IS, Soper JT, Clarke-Pearson DL. Epidemiologic and surgicopathologic findings of papillary serous and clear cell endometrial cancers when compared to endometrioid carcinoma. Gynecol Oncol. 1999 Sep;74(3):385-94. (1999) Abstract

Walsh R, Kornguth PJ, Soo MS, Bentley R, DeLong DM. Axillary lymph nodes: mammographic, pathologic, and clinical correlation. AJR Am J Roentgenol. 1997 Jan;168(1):33-8. (1997) Abstract

Query CC, Bentley RC, Keene JD. A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Cell. 1989 Apr 7;57(1):89-101. (1989) Abstract

Hankins GR, De Souza AT, Bentley RC, Patel MR, Marks JR, Iglehart JD, Jirtle RL. M6P/IGF2 receptor: a candidate breast tumor suppressor gene. Oncogene. 1996 May 2;12(9):2003-9. (1996) Abstract

Walmer DK, Padin CJ, Wrona MA, Healy BE, Bentley RC, Tsao MS, Kohler MF, McLachlan JA, Gray KD. Malignant transformation of the human endometrium is associated with overexpression of lactoferrin messenger RNA and protein. Cancer Res. 1995 Mar 1;55(5):1168-75. (1995) Abstract

Moore WF, Bentley RC, Kim KR, Olatidoye B, Gray SR, Robboy SJ. Goblet-cell mucinous epithelium lining the endometrium and endocervix: evidence of metastasis from an appendiceal primary tumor through the use of cytokeratin-7 and -20 immunostains. Int J Gynecol Pathol. 1998 Oct;17(4):363-7. (1998) Abstract

Zaino RJ, Kurman RJ, Brunetto VL, Morrow CP, Bentley RC, Cappellari JO, Bitterman P. Villoglandular adenocarcinoma of the endometrium: a clinicopathologic study of 61 cases: a gynecologic oncology group study. Am J Surg Pathol. 1998 Nov;22(11):1379-85. (1998) Abstract

Washington K, Bentley RC, Green A, Olson J, Treem WR, Krigman HR. Gastric graft-versus-host disease: a blinded histologic study. Am J Surg Pathol. 1997 Sep;21(9):1037-46. (1997) Abstract

Query CC, Bentley RC, Keene JD. A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component. Mol Cell Biol. 1989 Nov;9(11):4872-81. (1989) Abstract

Robboy SJ, Bentley RC, Krigman H, Silverberg SG, Norris HJ, Zaino RJ. Synoptic reports in gynecologic pathology. Int J Gynecol Pathol. 1994 Apr;13(2):161-74. (1994) Abstract