Daniel J. Sexton, MD

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Services

• Infectious Diseases

Department / Division:
Medicine / Infectious Diseases and International Health

Address:
DUMC 3605
Durham, NC 27710

Appointment Telephone:
919-668-7630

Fax Telephone:
919-479-2948

• MD, Northwestern University Feinberg School of Medicine (Illinois), 1971
• Centers for Disease Control, 1972-1974

• Infectious Disease, Duke University Medical Center, 1974-1975
• Medicine, University of Missouri Medical Center, 1975-1977

Clinical Interests:
Rocky Mountain spotted fever, Ehrlichiosis, hospital-acquired infections, endocarditis, surgical wound and bone and joint infections

Research Interests:
During the last seven years, a total of 8 students have done research with Dr. Sexton during their third year at Duke Medical School.  All but one of these students studied clinical aspects of endocarditis and worked with Dr. Sexton and other members of the Duke Endocarditis Service.   Recently Dr. Cabell became a co-mentor with Dr. Sexton for third year students.

The Duke Endocarditis Service was founded in 1994 and currently consists of several cardiologists and infectious disease specialists who supervise the collection and analysis of data from all patients with endocarditis at Duke Univeristy Medical Center.  The International Collaboration on Endocarditis (ICE) was founded in 2000.  ICE now consists of researchers from over 40 medical centers on 17 countries.  Data collected from these centers are organized and analyzed by Dr. Cabell and other members of the Duke Endocarditis Service working at the Duke Clinical Research Institute.  Studnets working with Drs. Sexton and Cabell use the facilities and data in the Duke Endocarditis Database, and in ICE to study clinically relevant questions on the clinical features, complications and outcomes of IE.  The ICE database now includes prospectively collected detailed clinical data on over 1500 patients with endocarditis throughout the world and the Duke endocarditis database contains data on over 700 patients hospitalized at DUMC since 1994.  Prior third-year medical students have studies the outcome and clinical features of prosthetic valve endocarditis, the risk of emboli in patients with aortic and mitral valve endocarditis, the clinical features of patients with recurrent endocarditis, risk factors for enterococcal endocarditis, and the role of gender in the risk of complications and outcome of treatment of endocarditis.

Key words that characterize my work:  Infective endocarditis, prosthetic valve endocarditis, mediastinitis, surgical site infections and nosocomial infections.

Representative Publications:
Anderson DJ, Corey GR, Cabell CH, Goldstein LG, Wilkinson WE, Sexton DJ.  Clinical characteristics and severity of stroke patients with infective endocarditis.  Neurology 2003; 24:776-778 (2003)

Cabell CH, Jollis JG, Peterson GE, Corey GR, Anderson DJ, Sexton DJ, Woods WE, REller LB, Ryan T, Fowler VG Jr.  Changing patient characteristics and the effect of mortality in endocarditis.  Arch Intern Med 2002; 162:90-94. (2002)

Cabell CH, Pond KK, Peterson GE, Durack DT, Corey GR, Anderson DJ, Ryan T, Lukes AS, Sexton DJ.  The risk of stroke and death in patients with aortic and mitral valve endocarditis.  Am Heart J 2001; 142:75-80. (2001)

Roe MT, Abramson MA, Li J, Heinle SK, Kisslo J, Corey GR, Sexton DJ. Clinical information determines the impact of transesophageal echocardiography on the diagnosis of infective endocarditis by the Duke criteria. Am Heart J 2000; 139:45-51. (2000)

Li JS, Sexton DJ, Mick N, Nettles RF, Fowler VG Jr, Ryan T, Bashore T, Corey GR. Proposed modifications of the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis 2000; 30: 633-639. (2000)

Sexton DJ, Tenenbaum M, Wilson W, Steckelberg J, Tice A, Gilbert D, Dismukes W, Drew R, Durack DT, and the ETC group. Ceftriaxone once daily for 4 weeks compared with Ceftriaxone plus gentamicin for 2 weeks for treatment of penicillin-susceptible endocarditis. Clin Infect Dis 1998; 27:1470-1474. (1998)