Michael M. Haglund, MD, PhD

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Services

• Epilepsy
• Spine Center

Department / Division:
Surgery / Neurosurgery

Address:
DUMC 3807
Durham, NC 27710

Appointment Telephone:
(919) 681-1684

Office Telephone:
(919) 684-6936

Fax Telephone:
(919) 681-6566

• M.D., University of Washington, 1987

• Neurosurgery, University of Washington, 1987-94

• Epilepsy, University of Washington, 1995

• Ph.D., University of Washington, 1988

Clinical Interests:
Subspecialty: epilepsy surgery, vagal nerve stimulators; spine surgery: microscopic and minimally-invasive cervical, thoracic, and lumbar disc disease, endoscopic disc surgery as well as outpatient spinal surgery, functional brain mapping for tumors, epilepsy, and vascular lesions

Research Interests:
Clinically, my areas of subspecialty in Neurosurgery include: the surgical treatment of epilepsy and functional mapping for resection of brain tumors.  The major areas of research that have developed from this include: the cortical organization of higher cognitive functions as well as the mechanisms and pathways underlying the propagation of seizure activity.  Research into the cortical organization of higher cognitive functions include: language organization, memory and face processing involving electrical stimulation mapping in patients undergoing awake craniotomies and the use of optical imaging to localize areas of the neocortex serving specific cognitive processes.  The mechanisms underlying the pathways and propagation of seizures involves using two models.  The in vivo model, primate visual cortex, provides access to understanding the functional organization of the primate visual cortex and how seizure activity spreads through these known pathways.  The pathways are investigated using microelectrode recordings as well as optical imaging.  The second model, an in vitro slice preparation, involves using both rat and human neocortical slices.  Propagation of seizure activity through normal pathways is studied using intracellular and extracellular electrode recording which is combined with optical imaging of the normal activity and abnormal seizure activity propagation.  By better understanding how the normal cortex in humans is organized and how abnormal activity such as seizures is propagated, improvements in the surgical treatment of epilepsy will be accomplished.  Other areas of interests include the use of dynamic optical imaging to study the grading and localization of intrinsic brain tumors.  As one of the authors on two U.S. patents which involves this technique, the ability to study brain tumors and other tumors not involving the brain using optical imaging may improve our ability to obtain more complete resections and to noninvasively screen and monitor many types of tumors.

Representative Publications:
Haglund MM and Walker DH. Optical imaging for localization of cortical activity. In Advanced Neurosurgical Navigation, eds. E. Alexander III and RJ Maciunas, Thieme, pp. 209-216, 1999. (1999)

Little KL and Haglund MM. Optical imaging techniques in the operating room. Textbook of Neurological Surgery, 2001. (2001)

Cerne R, Haglund MM. Electrophysiological correlates to the intrinsic optical signal in the rat neocortical slice. Neurosci Lett. 2002 Jan 14;317(3):147-50. (2002) Abstract

Macknik SL, Martinez-Conde S, Haglund MM. The role of spatiotemporal edges in visibility and visual masking. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7556-60. (2000) Abstract

Macknik SL, Haglund MM. Optical images of visible and invisible percepts in the primary visual cortex of primates. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15208-10. (1999) Abstract

Borel CO, McKee A, Parra A, Haglund MM, Solan A, Prabhakar V, Sheng H, Warner DS, Niklason L. Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage.  Stroke.  2003 Feb;34(2):427-33. (2003) Abstract

Haglund MM, Hochman DW. Furosemide and Mannitol Suppression of Epileptic Activity in the Human Brain.  J Neurophysiol.  2005 Feb 23. (2005) Abstract

Haglund MM, Ojemann GA and Berger MS. Functional mapping of motor, sensory and language cortex during ultrasound tumor removal. In Textbook of Stereotactic and Functional Neurosurgery, eds. PL Gildenberg and RR Tasker, McGraw-Hill, New York, pp. 955-962, 1998. (1999)

Friedman HS, Petros WP, Friedman AH, Schaaf LJ, Kerby T, Lawyer J, Parry M, Houghton PJ, Lovell S, Rasheed K, Cloughsey T, Stewart ES, Colvin OM, Provenzale JM, McLendon RE, Bigner DD, Cokgor I, Haglund MM, Rich J, Ashley D, Malczyn J, Elfring GL and Miller LL. Irinotecan therapy in adults with recurrent or progressive malignant glioma. J. Clinical Oncology 17:1516-1525, 1999. (1999)

Haglund MM and Olson TJ. Optical imaging of epilepsy. Operative Neurosurgical Techniques, ed. Schmidek HH, Saunders, pp. 1529-1535. (2001)

Quinn JA, Pluda J, Dolan ME, Delaney S, Kaplan R, Rich JN, Friedman AH, Reardon DA, Sampson JH, Colvin OM, Haglund MM, Pegg AE, Moschel RC, McLendon RE, Provenzale JM, Gururangan S, Tourt-Uhlig S, Herndon JE 2nd, Bigner DD, Friedman HS. Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J Clin Oncol. 2002 May 1;20(9):2277-83. (2002) Abstract

McKhann GM 2nd, Schoenfeld-McNeill J, Born DE, Haglund MM, Ojemann GA. Intraoperative hippocampal electrocorticography to predict the extent of hippocampal resection in temporal lobe epilepsy surgery. J Neurosurg. 2000 Jul;93(1):44-52. (2000) Abstract

Muñana KR, Vitek SM, Tarver WB, Saito M, Skeen TM, Sharp NJ, Olby NJ, Haglund MM. Use of vagal nerve stimulation as a treatment for refractory epilepsy in dogs. J Am Vet Med Assoc. 2002 Oct 1;221(7):977-83. (2002) Abstract

Friedman HS, Pluda J, Quinn JA, Ewesuedo RB, Long L, Friedman AH, Cokgor I, Colvin OM, Haglund MM, Ashley DM, Rich JN, Sampson J, Pegg AE, Moschel RC, McLendon RE, Provenzale JM, Stewart ES, Tourt-Uhlig S, Garcia-Turner AM, Herndon JE 2nd, Bigner DD, Dolan ME. Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol. 2000 Oct 15;18(20):3522-8. (2000) Abstract

Schwartz TH, Haglund MM, Lettich E, Ojemann GA. Asymmetry of neuronal activity during extracellular microelectrode recording from left and right human temporal lobe neocortex during rhyming and line-matching. J Cogn Neurosci. 2000 Sep;12(5):803-12. (2000) Abstract

Speciale AC, Pietrobon R, Urban CW, Richardson WJ, Helms CA, Major N, Enterline D, Hey L, Haglund MM, and Turner DA.  Observer variability in asessing lumbar spinal stenosis severity on magnetic resonance imaging and its relation to cross-sectional canal area.  Spine 27:1082-1086, 2002. (2002)

Haglund MM, Hochman DW. Optical imaging of epileptiform activity in human neocortex.  Epilepsia.  2004;45 Suppl 4:43-7. (2004) Abstract

Haglund MM, Hochman DW. Furosemide and mannitol suppression of epileptic activity in the human brain.  J Neurophysiol.  2005 Aug;94(2):907-18. (2005) Abstract