Brian G. Czito, MD

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• Bone and Soft Tissue Cancer
• Breast Cancer
• Esophageal Cancer
• Gastrointestinal Cancer
• Head and Neck Cancer
• Lung Cancer
• Skin Cancer

Department / Division:
Radiation Oncology / Radiation Oncology

Address:
DUMC 3085
Durham, NC 27710

Appointment Telephone:
919-660-2100

Office Telephone:
919-668-7336

Fax Telephone:
919-668-7345

• MD, Medical College of Georgia School of Medicine, 1996

• Radiation Oncology, Massachusetts General Hospital, 1997-2001

Clinical Interests:
Radiation oncology, gastrointestinal radiation oncology including esophagus, stomach, pancreas, hepatobiliary, colon, rectum, and anus, phase I clinical trials

Research Interests:
His research interests include gastrointestinal malignancies, including treatment and integration of novel systemic agents with radiation therapy in the treatment of esophageal, gastric, hepatobiliary, pancreatic, colorectal and anal malignancies; phase I/II clinical trials evaluating novel systemic/targeted agents in conjunction with radiation therapy; investigation and optimization of the treatment of gastrointestinal malignancies, with focus on the above tumor sites.

Representative Publications:
Willett CG, Czito BG, C. Bendell JC. Cancer of the Pancreas. In Principles and Practice of Radiation Oncology. Perez C, Brady L, Halperin E, Eds; Fifth Edition Lippincott, Williams and Wilkins p1336-1348 (2008)

Willett CG, Czito BG, Bendell JC. Adjuvant therapy in pancreatic cancer. In  Seminars in Oncology (editor review/in press). (2008)

Mohiuddin M, Czito BG, Willett CG. Cancer of the Colon and Rectum. In Principles and Practice of Radiation Oncology. Perez C, Brady L, Halperin E, Eds; 5th Edition. Lippincott, Williams and Wilkins p1366-1382 (2008)

Czito BG, DeNittis A, Willett CG. Cancer of the Esophagus. In Principles and Practice of Radiation Oncology. Perez C, Brady L, Halperin E, Eds; 5th Edition. Lippincott, Williams and Wilkins p1131-1153. (2008)

Czito BG, Cohen DP, Kelsey CR, Lockhart AC, Bendell JC, Willett CG, Petros WP, D'Amico TA, Truax R, Hurwitz HI. A Phase I Study of UFT/Leucovorin, Carboplatin, and Paclitaxel in Combination With External Beam Radiation Therapy for Advanced Esophageal Carcinoma. Int J Radiat Oncol Biol Phys. 2008 Mar 15;70(4):1066-72. (2008) Abstract

Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, Ludwig KA, Jain RK. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nat Clin Pract Oncol. 2007 May;4(5):316-21. (2007) Abstract

Willett CG, Duda DG, Czito BG, Bendell JC, Clark JW, Jain RK. Targeted therapy in rectal cancer. Oncology (Williston Park). 2007 Aug;21(9):1055-65; discussion 1065, 1070, 1075 passim. (2007) Abstract

Willett CG, Czito BG, Tyler DS. Intraoperative radiation therapy. J Clin Oncol. 2007 Mar 10;25(8):971-7. (2007) Abstract

Willett CG, Czito BG, Bendell JC. Radiation therapy in stage II and III rectal cancer. Clin Cancer Res. 2007 Nov 15;13(22 Pt 2):6903s-8s. (2007) Abstract

Willett CG, Czito BG, Bendell JC. Adjuvant therapy of pancreatic cancer. Cancer J. 2007 May-Jun;13(3):185-91. (2007) Abstract

Meyer JM, Czito BG, Willett CG. Particle radiotherapy for gastrointestinal malignancies. Gastrointestinal Cancer Research 2007; 1 (suppl 2): S54-S63. (2007)

Meyer J, Czito B, Yin FF, Willett C. Advanced radiation therapy technologies in the treatment of rectal and anal cancer: intensity-modulated photon therapy and proton therapy. Clin Colorectal Cancer. 2007 Jan;6(5):348-56. (2007) Abstract

Kelsey CR, Nelson JW, Willett CG, Chino JP, Clough RW, Bendell JC, Tyler DS, Hurwitz HI, Morse MA, Clary BM, Pappas TN, Czito BG. Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1436-41. (2007) Abstract

Kelsey CR, Chino JP, Willett CG, Clough RW, Hurwitz HI, Morse MA, Bendell JC, D'Amico TA, Czito BG. Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer. Int J Radiat Oncol Biol Phys. 2007 Nov 1;69(3):770-6. (2007) Abstract

Czito BG, Willett CG. Rationale, design and results of clinical trials combining radiotherapy with antiangiogenic therapy in rectal cancer (Expert column) Medscape September 2007(Online) (2007)

Czito BG, Willett CG. Editorial "Contemporary Management of Rectal Cancer: New Standards, Mounting Questions, Emerging Challenges" Gastrointestinal Cancer Research 1: pg 66-67, 2007. (2007)

Czito BG, Willett CG. Commentary: rectal cancer an evolution of treatment. Oncologist. 2007 Nov;12(11):1319-20. (2007) Abstract

Czito BG, Willett CG, Bendell JC. Combined-modality therapy for rectal cancer: future prospects. Clin Colorectal Cancer. 2007 Sep;6(9):625-33. (2007) Abstract

Czito BG, Kelsey CR, Hurwitz HI, Willett CG, Morse MA, Blobe GC, Fernando NH, D'Amico TA, Harpole DH, Honeycutt W, Yu D, Bendell JC. A Phase I study of capecitabine, carboplatin, and paclitaxel with external beam radiation therapy for esophageal carcinoma. Int J Radiat Oncol Biol Phys. 2007 Mar 15;67(4):1002-7. (2007) Abstract

Czito BG, Bendell JC, Willett CG, Morse MA, Blobe GC, Tyler DS, Thomas J, Ludwig KA, Mantyh CR, Ashton J, Yu D, Hurwitz HI. Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results. Int J Radiat Oncol Biol Phys. 2007 Jun 1;68(2):472-8. (2007) Abstract

Czito BG, Willett CG. Intraoperative Irradiation. In Gunderson LL, Tepper JE. Clinical Radiation Oncology, 2nd edition, Chapter 15, p 315-329 (2006) (2006)

Czito BG, Willett CG. Colon Cancer. In Gunderson LL, Tepper JE. Clinical Radiation Oncology, 2nd edition Chapter 47, p 1101-1111 (2006). (2006)

Czito BG, Willett CG, Bendell JC, Morse MA, Tyler DS, Fernando NH, Mantyh CR, Blobe GC, Honeycutt W, Yu D, Clary BM, Pappas TN, Ludwig KA, Hurwitz HI. Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results. J Clin Oncol. 2006 Feb 1;24(4):656-62. (2006) Abstract

Czito BG, Siddidi NH, Mamon HJ, et al. Gastrointestinal Brachytherapy. In Devlin P. Brachytherapy: Applications and Techniques, 1st edition, Lippincott, Williams and Wilkins p159-180 (2006). (2006)

Czito BG, Hong TJ, Cohen DP, Petros WP, Tyler DS, Pappas TN, Yu D, Lee CG, Lockhart AC, Morse MA, Fernando N, Hurwitz HI. A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract. Cancer Invest. 2006 Feb;24(1):9-17. (2006) Abstract

Czito BG, Bendell J, Willett CG. Radiation therapy for resectable colon cancer. Is there a role in the modern chemotherapy era? Oncology (Williston Park). 2006 Feb;20(2):179-87; discussion 187-8, 192. (2006) Abstract

Czito BG, Anscher MS, Willett CG. Radiation therapy in the treatment of cholangiocarcinoma. Oncology (Williston Park). 2006 Jul;20(8):873-84; discussion 886-8, 893-5. (2006) Abstract

Czito BG, Anscher MA. Radiation Therapy for Disease of the Biliary Tree and Gallbladder. In Clavien PA, Baillie J. Diseases of the Gallbladder and Bile Ducts, 2nd edition, Blackwell Publishing; p147-162 (2006). (2006)

Czito BG  “Prevention of Radiation Proctitis”. In UpToDate online reviews May 2006. (2006)

Willett CG, Czito BG, Bendell JC, Ryan DP. Locally advanced pancreatic cancer. J Clin Oncol. 2005 Jul 10;23(20):4538-44. (2005) Abstract

White RR, Xie HB, Gottfried MR, Czito BG, Hurwitz HI, Morse MA, Blobe GC, Paulson EK, Baillie J, Branch MS, Jowell PS, Clary BM, Pappas TN, Tyler DS. Significance of histological response to preoperative chemoradiotherapy for pancreatic cancer. Ann Surg Oncol. 2005 Mar;12(3):214-21. (2005) Abstract

Czito BG, Hurwitz HI, Clough RW, Tyler DS, Morse MA, Clary BM, Pappas TN, Fernando NH, Willett CG. Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience. Int J Radiat Oncol Biol Phys. 2005 Jul 15;62(4):1030-4. (2005) Abstract

Czito B, Willett C. Editorial review/commentary on “Neoadjuvant therapy for gastric cancer” Chadra M, Kuvshinoff B, Javle M. Oncology 19: 1231-1232, 2005. (2005)

Czito B, Tyler D, Willett C. Editorial review/commentary on “Combined-modality treatment for operable pancreatic adenocarcinoma”. Pisters P, Wolff R, Crane C, Evans D. Oncology 19: 412-416, 2005. (2005)

Gerke H, White R, Byrne MF, Stiffier H, Mitchell RM, Hurwitz HI, Morse MA, Branch MS, Jowell PS, Czito B, Clary B, Pappas TN, Tyler DS, Baillie J. Complications of pancreaticoduodenectomy after neoadjuvant chemoradiation in patients with and without preoperative biliary drainage. Dig Liver Dis. 2004 Jun;36(6):412-8. (2004) Abstract

Czito BG, Hong TJ, Cohen DP, Tyler DS, Lee CG, Anscher MS, Ludwig KA, Seigler HF, Mantyh C, Morse MA, Lockhart AC, Petros WP, Honeycutt W, Spector NL, Ertel PJ, Mangum SG, Hurwitz HI. A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon. Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):779-85. (2004) Abstract

Czito B, Zietman A, Kaufman D, Skowronski U, Shipley W. Adjuvant radiotherapy with and without concurrent chemotherapy for locally advanced transitional cell carcinoma of the renal pelvis and ureter. J Urol. 2004 Oct;172(4 Pt 1):1271-5. (2004) Abstract

Czito BG, Willett CG, Clark JW, DelCastillo CF. Chemoradiation for Unresectable Pancreatic Cancer.  In Cameron JL Pancreatic Cancer: American Cancer Society Atlas of Clinical Oncology (2001)

Czito BG, Willett CG, Clark JW, Fernandez Del Castillo C. Current perspectives on locally advanced pancreatic cancer. Oncology (Williston Park). 2000 Nov;14(11):1535-45; discussion 1546, 1549-52. (2000) Abstract