Darrell V. Lewis, MD

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• Epilepsy

Department / Division:
Pediatrics / Neurology

Address:
DUMC 3936
Durham, NC 27710

Office Telephone:
919-668-0477

Fax Telephone:
919-681-8943

• MD, University of Minnesota Medical School, 1969

• Pediatrics, Johns Hopkins Hospital (Maryland), 1969-1971
• Neurology, Johns Hopkins Hospital (Maryland), 1975-1978

Clinical Interests:
Epilepsy

Research Interests:
Current  Research Efforts:
Explore the relationship between prolonged febrile convulsions, temporal lobe epilepsy and hippocampal sclerosis;  The hypothesis that prolonged febrile convulsions cause hippocampal injury that evolves to sclerosis and then to temporal lobe epilepsy has been promulgated for decades since the advent of surgical treatment of temporal lobe epilepsy.  However, this concept has never been addressed with a  prospective clinical study.  With the availability of magnetic resonance imaging techniques capable of discerning hippocampal edema and measuring hippocampal volume, patients suffering from these seizures can now be studied acutely and chronically to determine if hippocampal injury does occur during them and under what clinical circumstances.  We are conducting a longterm study of this phenomenon in cooperation with 5 other medical centers which will prospectively enroll 200 infants presenting with febrile status epilepticus and follow these infants for 10 - 15 years with sequential neuroimaging, electroencephalographic and developmental testing to determine the long term consequences of these infantile seizures.  

Representative Publications:
Provenzale JM, Barboriak DP, VanLandingham K, MacFall J, Delong D, Lewis DV. Hippocampal MRI signal hyperintensity after febrile status epilepticus is predictive of subsequent mesial temporal sclerosis. AJR Am J Roentgenol. 2008 Apr;190(4):976-83. (2008) Abstract

Li Q, Kuhn CM, Wilson WA, Lewis DV. Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex. Neuroscience. 2007 Nov 30;150(1):82-92. (2007) Abstract

Lewis DV. Losing neurons: selective vulnerability and mesial temporal sclerosis. Epilepsia. 2005;46 Suppl 7:39-44. (2005) Abstract

Li, Q, Guo-Ross, S, Lewis, DV, Turner, D, White, AM, Wilson, WA, and Swartzwelder, HS.  Dietary prenatal choline supplementation enhances excitatory function and morphology of hippocampal CA1 pyramidal cells. Journal of Neurophysiology. 91(4):1545-55, 2004 Apr. (2004)

Li Q, Clark S, Lewis DV, Wilson WA. NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity. J Neurosci. 2002 Apr 15;22(8):3070-80. (2002) Abstract

Lewis DV, Barboriak DP, MacFall JR, Provenzale JM, Mitchell TV, VanLandingham KE. Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions. Prog Brain Res. 2002;135:263-78. (2002) Abstract

Wainwright MS, Martin PL, Morse RP, Lacaze M, Provenzale JM, Coleman RE, Morgan MA, Hulette C, Kurtzberg J, Bushnell C, Epstein L, Lewis DV. Human herpesvirus 6 limbic encephalitis after stem cell transplantation. Ann Neurol. 2001 Nov;50(5):612-9. (2001) Abstract

Verma, A, Lewis, D, Vanlandingham, KE, Husain, AM, Friedman, AH, Thompson, E, and Radtke, RA.  Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy.  Epil Res  47:9-15, 2001. (2001)

Kassem-Moussa H, Provenzale JM, Petrella JR, Lewis DV. Early diffusion-weighted MR imaging abnormalities in sustained seizure activity. AJR Am J Roentgenol. 2000 May;174(5):1304-6. (2000) Abstract

Foldvary N, Nashold B, Mascha E, Thompson EA, Lee N, McNamara JO, Lewis DV, Luther JS, Friedman AH, Radtke RA. Seizure outcome after temporal lobectomy for temporal lobe epilepsy: a Kaplan-Meier survival analysis. Neurology. 2000 Feb 8;54(3):630-4. (2000) Abstract

Mott DD, Li Q, Okazaki MM, Turner DA, Lewis DV. GABAB-Receptor-mediated currents in interneurons of the dentate-hilus border. J Neurophysiol. 1999 Sep;82(3):1438-50. (1999) Abstract

Xie, C.W. and Lewis, D.V. Blocking opioid receptors unmasks LTP of synaptic inhibition in the dentate gyrus. Regulatory Peptides 54:73-74,1994. (1994)