Coleen K. Cunningham, MD

Chief

Department / Division:
Pediatrics / Infectious Diseases

Address:
DUMC 3499
Durham, NC 27710

Appointment Telephone:
919-668-4000

Office Telephone:
919-684-6335

Fax Telephone:
919-668-4859

• MD, SUNY Upstate Medical University College of Medicine, 1985

• Pediatrics, State University of New York Health Science Center at Syracuse, 1985-1988

• Pediatric Infectious Disease, State University of New York Health Science Center at Syracuse, 1988-1991

Clinical Interests:
Infections, unexplained fevers, meningitis, pneumonia, bone and joint infections, viral disease, pediatric HIV

Research Interests:
Pediatric HIV treatment
Prevention of perinatal transmission of HIV
Care of HIV infected children in the International setting
HIV vaccine in children and adolescents

Representative Publications:
Kiser JJ, Fletcher CV, Flynn PM, Cunningham CK, Wilson CM, Kapogiannis BG, Major-Wilson H, Viani RM, Liu NX, Muenz LR, Harris DR, Havens PL, . Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection. Antimicrob Agents Chemother. 2008 Feb;52(2):631-7. (2008) Abstract

Jaspan HB, Cunningham CK, Tucker TJ, Wright PF, Self SG, Sheets RL, Rogers AS, Bekker LG, Wilson CM, Duerr A, Wasserheit JN, . Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroads. J Acquir Immune Defic Syndr. 2008 Jan 1;47(1):86-92. (2008) Abstract

Witt KL, Cunningham CK, Patterson KB, Kissling GE, Dertinger SD, Livingston E, Bishop JB. Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV. Environ Mol Mutagen. 2007 Apr-May;48(3-4):322-9. (2007) Abstract

Newell ML, Huang S, Fiore S, Thorne C, Mandelbrot L, Sullivan JL, Maupin R, Delke I, Watts DH, Gelber RD, Cunningham CK, . Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA. BMC Infect Dis. 2007;7:60. (2007) Abstract

McKinney RE Jr, Rodman J, Hu C, Britto P, Hughes M, Smith ME, Serchuck LK, Kraimer J, Ortiz AA, Flynn P, Yogev R, Spector S, Draper L, Tran P, Scites M, Dickover R, Weinberg A, Cunningham C, Abrams E, Blum MR, Chittick GE, Reynolds L, Rathore M, . Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021. Pediatrics. 2007 Aug;120(2):e416-23. (2007) Abstract

Ku CL, von Bernuth H, Picard C, Zhang SY, Chang HH, Yang K, Chrabieh M, Issekutz AC, Cunningham CK, Gallin J, Holland SM, Roifman C, Ehl S, Smart J, Tang M, Barrat FJ, Levy O, McDonald D, Day-Good NK, Miller R, Takada H, Hara T, Al-Hajjar S, Al-Ghonaium A, Speert D, Sanlaville D, Li X, Geissmann F, Vivier E, Maródi L, Garty BZ, Chapel H, Rodriguez-Gallego C, Bossuyt X, Abel L, Puel A, Casanova JL. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med. 2007 Oct 1;204(10):2407-22. (2007) Abstract

Dixon TC, Cunningham CK. Treatment of children with HIV infection. Curr HIV/AIDS Rep. 2007 May;4(2):93-9. (2007) Abstract

Watts DH, Balasubramanian R, Maupin RT Jr, Delke I, Dorenbaum A, Fiore S, Newell ML, Delfraissy JF, Gelber RD, Mofenson LM, Culnane M, Cunningham CK,  . Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316.  Am J Obstet Gynecol.  2004 Feb;190(2):506-16. (2004) Abstract

Cunningham CK, Balasubramanian R, Delke I, Maupin R, Mofenson L, Dorenbaum A, Sullivan JL, Gonzalez-Garcia A, Thorpe E, Rathore M, Gelber RD. The Impact of Race/Ethnicity on Mother-to-Child HIV Transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316.  J Acquir Immune Defic Syndr.  2004 Jul 1;36(3):800-807. (2004) Abstract

Church JA, Hughes M, Chen J, Palumbo P, Mofenson LM, Delora P, Smith E, Wiznia A, Hawkins E, Sista P, Cunningham CK,  . Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected children.  Pediatr Infect Dis J.  2004 Aug;23(8):713-8. (2004) Abstract

Dorenbaum A, Cunningham CK, Gelber RD, Culnane M, Mofenson L, Britto P, Rekacewicz C, Newell ML, Delfraissy JF, Cunningham-Schrader B, Mirochnick M, Sullivan JL,  . Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial.  JAMA.  2002 Jul 10;288(2):189-98. (2002) Abstract

Cunningham CK, Chaix ML, Rekacewicz C, Britto P, Rouzioux C, Gelber RD, Dorenbaum A, Delfraissy JF, Bazin B, Mofenson L, Sullivan JL. Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 316.  J Infect Dis.  2002 Jul 15;186(2):181-8. (2002) Abstract

Church JA, Cunningham C, Hughes M, Palumbo P, Mofenson LM, Delora P, Smith E, Wiznia A, Purdue L, Hawkins E, Sista P,  . Safety and antiretroviral activity of chronic subcutaneous administration of T-20 in human immunodeficiency virus 1-infected children.  Pediatr Infect Dis J.  2002 Jul;21(7):653-9. (2002) Abstract

McFarland EJ, Borkowsky W, Fenton T, Wara D, McNamara J, Samson P, Kang M, Mofenson L, Cunningham C, Duliege AM, Sinangil F, Spector SA, Jimenez E, Bryson Y, Burchett S, Frenkel LM, Yogev R, Gigliotti F, Luzuriaga K, Livingston RA,  . Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine.  J Infect Dis.  2001 Nov 15;184(10):1331-5. (2001) Abstract

Cunningham CK, Wara DW, Kang M, Fenton T, Hawkins E, McNamara J, Mofenson L, Duliege AM, Francis D, McFarland EJ, Borkowsky W,  . Safety of 2 recombinant human immunodeficiency virus type 1 (HIV-1) envelope vaccines in neonates born to HIV-1-infected women.  Clin Infect Dis.  2001 Mar 1;32(5):801-7. (2001) Abstract

Borkowsky W, Wara D, Fenton T, McNamara J, Kang M, Mofenson L, McFarland E, Cunningham C, Duliege AM, Francis D, Bryson Y, Burchett S, Spector SA, Frenkel LM, Starr S, Van Dyke R, Jimenez E. Lymphoproliferative responses to recombinant HIV-1 envelope antigens in neonates and infants receiving gp120 vaccines. AIDS Clinical Trial Group 230 Collaborators.  J Infect Dis.  2000 Mar;181(3):890-6. (2000) Abstract

Cunningham CK, Charbonneau TT, Song K, Patterson D, Sullivan T, Cummins T, Poiesz B. Comparison of human immunodeficiency virus 1 DNA polymerase chain reaction and qualitative and quantitative RNA polymerase chain reaction in human immunodeficiency virus 1-exposed infants.  Pediatr Infect Dis J.  1999 Jan;18(1):30-5. (1999) Abstract

Cunningham CK, Bonville CA, Ochs HD, Seyama K, John PA, Rotbart HA, Weiner LB. Enteroviral meningoencephalitis as a complication of X-linked hyper IgM syndrome.  J Pediatr.  1999 May;134(5):584-8. (1999) Abstract

Coplan J, Contello KA, Cunningham CK, Weiner LB, Dye TD, Roberge L, Wojtowycz MA, Kirkwood K. Early language development in children exposed to or infected with human immunodeficiency virus.  Pediatrics.  1998 Jul;102(1):e8. (1998) Abstract

Flynn PM, Cunningham CK, Kerkering T, San Jorge AR, Peters VB, Pitel PA, Harris J, Gilbert G, Castagnaro L, Robinson P. Oropharyngeal candidiasis in immunocompromised children: a randomized, multicenter study of orally administered fluconazole suspension versus nystatin. The Multicenter Fluconazole Study Group.  J Pediatr.  1995 Aug;127(2):322-8. (1995) Abstract

Coplan J, Dye TD, Contello KA, Cunningham CK, Kirkwood K, Weiner LB. Failure to identify human immunodeficiency virus-seropositive newborns: epidemiology and enrollment patterns in a predominantly white, nonurban setting.  Pediatrics.  1995 Dec;96(6):1083-9. (1995) Abstract

Cunningham CK, McMillan JA, Gross SJ. Rehospitalization for respiratory illness in infants of less than 32 weeks' gestation.  Pediatrics.  1991 Sep;88(3):527-32. (1991) Abstract