Cristina Gasparetto, MD

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Services

• Adult Bone Marrow Transplant
• Emergency Services
• Leukemias and Lymphomas
• Transplants

Department / Division:
Medicine / Cellular Therapy

Address:
DUMC 3961
Durham, NC 27710

Appointment Telephone:
(919) 668-1002

Office Telephone:
(919) 668-1017

Fax Telephone:
(919) 668-1091

• M.D., University of Rome "La Sapienza", Rome, Italy, 1986

• Internal Medicine, Duke University Medical Center, North Carolina, 1993-1996
• Hematology and Bone Marrow Transplant, Duke University Medical Center, North Carolina, 1996-1999

Clinical Interests:
Patients with hematologic malignancies that could be candidate for high dose chemotherapy and stem cell support; multiple myeloma

Research Interests:
Dr. Gasparetto performs both laboratory and clinical research in the field of multiple myeloma. Her primary research interests are in developing immunotherapy approaches to treating multiple myeloma particularly in conjunction with hematopoietic stem cell transplantation. Ongoing laboratory research projects include the development of dendritic cell vaccines and antibody therapies. Clinical studies include a recently approved trial involving vaccination with autologous dendritic cells pulsed with idiotypic protein following high dose chemotherapy and autologous peripheral blood stem cells transplant. Upcoming trials include novel antibody therapies for multiple myeloma. Dr. Gasparetto is also an investigator on several other clinical trials for myeloma including non-myeloablative allogeneic transplantation, high dose sequential chemotherapy and autologous peripheral blood stem cell transplantation and transplantation of partially HLA matched unrelated cord blood.

Representative Publications:
5. Gasparetto C, Smith C, Gillio A, Stoppa AM, Moore MAS, and O'Reilly RJ. Enrichment of Peripheral Blood Stem Cells with Administration of a Single Dose of IL-1 in a Primate Model. Bone Marrow Transplantation, 14(5):717, 1994 (1994)

Rizzieri DA, Long GD, Vredenburgh JJ, Gasparetto C, Morris A, Davis P, Chao NJ. Successful allogeneic transplantation using a non-myeloablative preparative regimen followed by infusion of mismatched unrelated cord blood. Subm. for publ.

Miralles D, Gasparetto M, Patel D, Gasparetto C, Gentry T, Fernandez M, and Smith C. Thymic epithelial cells can fully support the differentiation of authentic human thymic dendritic cells from hematopoietic stem cells Subm. for publ.

Long GD, Madan B, Kurtzberg J, Rubinstein P, Gasparetto C, Rizzieri D, Smith C, Vredenburgh J, Halperin E, Broadwater G, Niedzwiecki D, and Chao N. Unrelated Umbilical Cord Blood Transplantation in Adult Patients. Subm. for Publ.

Gasparetto C, Vredenberg J, Long G, Rizzieri D, Chao N, Loftis J, and Smith C. Mobilization of dendritic cells from patients with breast cancer using Flt-3-ligand in combination with G-CSF or GM-CSF. Subm. for publ.