Paul Szabolcs, MD

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• Pediatric Blood and Marrow Transplant

Department / Division:
Pediatrics / Blood and Marrow Transplantation

Address:
DUMC 3350
Durham, NC 27710

Appointment Telephone:
(919) 668-1100

Office Telephone:
(919) 668-1122

Fax Telephone:
(919) 668-1180

• M.D., Semmelweis University School of Medicine, Budapest, Hungary, 1985

• Pediatrics, New York University, Bellevue Hospital Medical Center, 1987-1990
• Pediatric Hematology/Oncology, Memorial Sloan-Kettering Cancer Center, New York Hospital Cornell University Medical Center, 1990-1993
• The Department of Cellular Physiology and Immunology, The Rockefeller University, New York, 1993-1997

Clinical Interests:
Bone marrow and cord blood transplantation, immune reconstitution, immunotherapy, graft engineering, graft-versus-host disease, immunodeficiency, MPS syndromes, autoimmunity, IBD/Crohn's disease

Research Interests:
My research interests are focused on understanding the biology of donor-derived cellular immunity in recipients of allogeneic hematopoietic cell transplantation (HCT)that can be translated into new immunotherapy strategies. Our overall goal is to develop novel approaches to accurately diagnose, predict, and therapeutically accelerate post transplant immune reconstitution without increasing graft versus host disease (GVHD). Our work has focused on unrelated cord blood transplantation (UCBT) as the dominant clinical scenario and laboratory model.

Current and future clinical projects

1)  Clinical studies of immune reconstitution after UCBT; Through detailed characterization of the earliest cellular events in immune reconstitution, we are developing predictive algorithms that identify patients at risk for opportunistic infection and/or GVHD.  
2)  Clinical and ancillary immune studies to test the safety and efficacy of new imunostimulatory agents such as rhu-growth hormone in transplnat recipients.
3)  Develop and test novel reduced intensity preparative regimens for patients with inborn errors of metabolism (such as MPS syndromes and trasnfusion dependent anemias) and primary immunodeficiency syndromes.
4)  Develop a clinical program in autologous HCT for treatment of autoimmune diseases such as Crohn’s diseas.

Our laboratory research efforts are conducted along two parallel avenues that have synergistic interactions.

1) Elucidate the biology of attaining antigen-specific protective immunity after UCBT.  
2) Develop, validate, and test in clinical trials novel graft engineering methods focusing on improving post-transplant lymphopenia both as a global and antigen-specific precursor deficit. We are developing strategies for ex vivo generation of anti-viral and anti-tumor donor lymphocytes available for adoptive transfer into transplant recipients.

Representative Publications:
Young JW, Szabolcs P, Moore MA. Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha. J Exp Med. 1995 Oct 1;182(4):1111-9. (1995) Abstract

Szabolcs P, Niedzwiecki D. Immune reconstitution after unrelated cord blood transplantation. Cytotherapy. 2007;9(2):111-22. (2007) Abstract

Szabolcs P, Park KD, Reese M, Marti L, Broadwater G, Kurtzberg J. Absolute values of dendritic cell subsets in bone marrow, cord blood, and peripheral blood enumerated by a novel method. Stem Cells. 2003;21(3):296-303. (2003) Abstract

Szabolcs P, Reese M, Yancey KB, Hall RP, Kurtzberg J. Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease. Bone Marrow Transplant. 2002 Sep;30(5):327-9. (2002) Abstract

Szabolcs P, Park KD, Marti L, Deoliveria D, Lee YA, Colvin MO, Kurzberg J. Superior depletion of alloreactive T cells from peripheral blood stem cell and umbilical cord blood grafts by the combined use of trimetrexate and interleukin-2 immunotoxin. Biol Blood Marrow Transplant. 2004 Nov;10(11):772-83. (2004) Abstract

Markert ML, Alexieff MJ, Li J, Sarzotti M, Ozaki DA, Devlin BH, Sempowski GD, Rhein ME, Szabolcs P, Hale LP, Buckley RH, Coyne KE, Rice HE, Mahaffey SM, Skinner MA. Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases. J Allergy Clin Immunol. 2004 Apr;113(4):734-41. (2004) Abstract

Mazur M, Kurtzberg J, Halperin E, Ciocci G, Szabolcs P. Transplantation of a child with sickle cell anemia with an unrelated cord blood unit after reduced intensity conditioning. J Pediatr Hematol Oncol. 2006 Dec;28(12):840-4. (2006) Abstract

Szabolcs P, Gallardo HF, Ciocon DH, Sadelain M, Young JW. Retrovirally transduced human dendritic cells express a normal phenotype and potent T-cell stimulatory capacity. Blood. 1997 Sep 15;90(6):2160-7. (1997) Abstract

Papadopoulos EB, Carabasi MH, Castro-Malaspina H, Childs BH, Mackinnon S, Boulad F, Gillio AP, Kernan NA, Small TN, Szabolcs P, Taylor J, Yahalom J, Collins NH, Bleau SA, Black PM, Heller G, O'Reilly RJ, Young JW. T-cell-depleted allogeneic bone marrow transplantation as postremission therapy for acute myelogenous leukemia: freedom from relapse in the absence of graft-versus-host disease. Blood. 1998 Feb 1;91(3):1083-90. (1998) Abstract

Schreiber AD, Nettl FM, Sanders MC, King M, Szabolcs P, Friedman D, Gomez F. Effect of endogenous and synthetic sex steroids on the clearance of antibody-coated cells. J Immunol. 1988 Nov 1;141(9):2959-66. (1988) Abstract

Szabolcs P, Moore MA, Young JW. Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha. J Immunol. 1995 Jun 1;154(11):5851-61. (1995) Abstract

Szabolcs P, Avigan D, Gezelter S, Ciocon DH, Moore MA, Steinman RM, Young JW. Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate. Blood. 1996 Jun 1;87(11):4520-30. (1996) Abstract

Park KD, Marti L, Kurtzberg J, Szabolcs P. In vitro priming and expansion of cytomegalovirus-specific Th1 and Tc1 T cells from naive cord blood lymphocytes. Blood. 2006 Sep 1;108(5):1770-3. (2006) Abstract