Daniel Benjamin Jr., MD, PhD, MPH

Department / Division:
Pediatrics / Infectious Diseases

Address:
Box 17969
Durham, NC 27715

Appointment Telephone:
919-668-7081

Office Telephone:
919-668-8295

Fax Telephone:
919-668-7058

• MD, University of Virginia School of Medicine, 1995

• Pediatrics, University of Virginia, 1998

• Infectious Disease, Duke University Medical Center, 2001

• MPH, University of North Carolina, 2001
• PhD, University of North Carolina at Chapel Hill, 2003

Clinical Interests:
Infections in the neonate, meningitis, infections in the bone marrow transplant patient, use of diagnostic tests

Research Interests:
Neonatal Infectious Disease:
1) Early diagnosis of neonatal candidiasis in a prospective study that is enrolling 1,750 extremely low birth weight infants. This is a public/private partnership
3) Randomized, blinded, multi-national pivotal study of the treatment of neonatal candidiasis. This is a public/private partnership
3) Diagnosis of neonatal meningitis. This is a collaborative study with a large private practice group
4) Pharmacokinetics of antibiotics and antifungals in neonates
Improved clinical trials design in children:
1) Noninferiority trial design
2) Dose response and safety outcomes in randomized trials
3) Data transparency

Representative Publications:
Hope WW, Mickiene D, Petraitis V, Petraitiene R, Kelaher AM, Hughes JE, Cotton MP, Bacher J, Keirns JJ, Buell D, Heresi G, Benjamin DK Jr, Groll AH, Drusano GL, Walsh TJ. The pharmacokinetics and pharmacodynamics of micafungin in experimental hematogenous Candida meningoencephalitis: implications for echinocandin therapy in neonates. J Infect Dis. 2008 Jan 1;197(1):163-71. (2008) Abstract

Crowley AL, Peterson GE, Benjamin DK Jr, Rimmer SH, Todd C, Cabell CH, Reller LB, Ryan T, Corey GR, Fowler VG Jr. Venous thrombosis in patients with short- and long-term central venous catheter-associated Staphylococcus aureus bacteremia. Crit Care Med. 2008 Feb;36(2):385-90. (2008) Abstract

Cohen-Wolkowiez M, Smith PB, Benjamin DK Jr, Fowler VG Jr, Wade KC. Daptomycin use in infants: report of two cases with peak and trough drug concentrations. J Perinatol. 2008 Mar;28(3):233-4. (2008) Abstract

Baddley JW, Benjamin DK Jr, Patel M, Miró J, Athan E, Barsic B, Bouza E, Clara L, Elliott T, Kanafani Z, Klein J, Lerakis S, Levine D, Spelman D, Rubinstein E, Tornos P, Morris AJ, Pappas P, Fowler VG Jr, Chu VH, Cabell C, . Candida infective endocarditis. Eur J Clin Microbiol Infect Dis. 2008 Feb 19. (2008) Abstract

Thornburg CD, Smith PB, Smithwick ML, Cotten CM, Benjamin DK Jr. Association between thrombosis and bloodstream infection in neonates with peripherally inserted catheters. Thromb Res. 2007 Nov 9. (2007) Abstract

Smith PB, Steinbach WJ, Cotten CM, Schell WA, Perfect JR, Walsh TJ, Benjamin DK Jr. Caspofungin for the treatment of azole resistant candidemia in a premature infant. J Perinatol. 2007 Feb;27(2):127-9. (2007) Abstract

Smith PB, Morgan J, Benjamin JD, Fridkin SK, Sanza LT, Harrison LH, Sofair AN, Huie-White S, Benjamin DK Jr. Excess costs of hospital care associated with neonatal candidemia. Pediatr Infect Dis J. 2007 Mar;26(3):197-200. (2007) Abstract

Smith PB, Benjamin DK Jr, Alexander BD, Johnson MD, Finkelman MA, Steinbach WJ. Quantification of 1,3-beta-D-glucan levels in children: preliminary data for diagnostic use of the beta-glucan assay in a pediatric setting. Clin Vaccine Immunol. 2007 Jul;14(7):924-5. (2007) Abstract

Santos RP, Sánchez PJ, Mejias A, Benjamin DK Jr, Walsh TJ, Patel S, Jafri HS. Successful medical treatment of cutaneous aspergillosis in a premature infant using liposomal amphotericin B, voriconazole and micafungin. Pediatr Infect Dis J. 2007 Apr;26(4):364-6. (2007) Abstract

Li JS, Eisenstein EL, Grabowski HG, Reid ED, Mangum B, Schulman KA, Goldsmith JV, Murphy MD, Califf RM, Benjamin DK Jr. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA. 2007 Feb 7;297(5):480-8. (2007) Abstract

Lenfestey RW, Smith PB, Moody MA, Clark RH, Cotten CM, Seed PC, Benjamin DK Jr. Predictive value of cerebrospinal fluid parameters in neonates with intraventricular drainage devices. J Neurosurg. 2007 Sep;107(3 Suppl):209-12. (2007) Abstract

Cohen-Wolkowiez M, Smith PB, Mangum B, Steinbach WJ, Alexander BD, Cotten CM, Clark RH, Walsh TJ, Benjamin DK Jr. Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures. J Perinatol. 2007 Feb;27(2):97-100. (2007) Abstract

Cohen-Wolkowiez M, Benjamin DK Jr, Fowler VG Jr, Wade KC, Alexander BD, Worley G, Goldstein RF, Smith PB. Mortality and neurodevelopmental outcome after Staphylococcus aureus bacteremia in infants. Pediatr Infect Dis J. 2007 Dec;26(12):1159-61. (2007) Abstract

Garges HP, Moody MA, Cotten CM, Smith PB, Tiffany KF, Lenfestey R, Li JS, Fowler VG Jr, Benjamin DK Jr. Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters? Pediatrics. 2006 Apr;117(4):1094-100. (2006) Abstract

Cotten CM, McDonald S, Stoll B, Goldberg RN, Poole K, Benjamin DK Jr, . The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics. 2006 Aug;118(2):717-22. (2006) Abstract

Benjamin DK, Schelonka R, White R, Holley HP, Bifano E, Cummings J, Adcock K, Kaufman D, Puppala B, Riedel P, Hall B, White J, Cotton CM, . A blinded, randomized, multicenter study of an intravenous Staphylococcus aureus immune globulin. J Perinatol. 2006 May;26(5):290-5. (2006) Abstract

Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, Duara S, Poole K, Laptook A, Goldberg R, . Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006 Jan;117(1):84-92. (2006) Abstract

Benjamin DK Jr, Smith PB, Murphy MD, Roberts R, Mathis L, Avant D, Califf RM, Li JS. Peer-reviewed publication of clinical trials completed for pediatric exclusivity. JAMA. 2006 Sep 13;296(10):1266-73. (2006) Abstract

Benjamin DK Jr, Driscoll T, Seibel NL, Gonzalez CE, Roden MM, Kilaru R, Clark K, Dowell JA, Schranz J, Walsh TJ. Safety and pharmacokinetics of intravenous anidulafungin in children with neutropenia at high risk for invasive fungal infections. Antimicrob Agents Chemother. 2006 Feb;50(2):632-8. (2006) Abstract

Tiffany KF, Benjamin DK, Palasanthiran P, O'donnell K, Gutman LT. Improved Neurodevelopmental Outcomes following Long-Term High-Dose Oral Acyclovir Therapy in Infants with Central Nervous System and Disseminated Herpes Simplex Disease. J Perinatol. 2004 Dec 16. (2004) Abstract

Benjamin DK, DeLong E, Cotten CM, Garges HP, Steinbach WJ, Clark RH. Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. J Perinatol. 2004 Mar;24(3):175-80. (2004) Abstract

Benjamin DK Jr, DeLong ER, Cotten CM, Garges HP, Clark RH. Postconception age and other risk factors associated with mortality following Gram-negative rod bacteremia. J Perinatol. 2004 Mar;24(3):169-74. (2004) Abstract

Benjamin DK Jr, Poole C, Steinbach WJ, Rowen JL, Walsh TJ. Neonatal candidemia and end-organ damage: a critical appraisal of the literature using meta-analytic techniques. Pediatrics. 2003 Sep;112(3 Pt 1):634-40. (2003) Abstract

Benjamin DK Jr, DeLong ER, Steinbach WJ, Cotton CM, Walsh TJ, Clark RH. Empirical therapy for neonatal candidemia in very low birth weight infants. Pediatrics. 2003 Sep;112(3 Pt 1):543-7. (2003) Abstract

Benjamin DK Jr, Miller W, Garges H, Benjamin DK, McKinney RE Jr, Cotton M, Fisher RG, Alexander KA. Bacteremia, central catheters, and neonates: when to pull the line. Pediatrics. 2001 Jun;107(6):1272-6. (2001) Abstract

Benjamin DK Jr, Ross K, McKinney RE Jr, Benjamin DK, Auten R, Fisher RG. When to suspect fungal infection in neonates: A clinical comparison of Candida albicans and Candida parapsilosis fungemia with coagulase-negative staphylococcal bacteremia. Pediatrics. 2000 Oct;106(4):712-8. (2000) Abstract