Division Chief

Department / Division:
Medicine / Dermatology

Address:
DUMC 3135
Durham, NC 27710

Appointment Telephone:
919-684-3432

Office Telephone:
919-684-3110

Fax Telephone:
919-684-3002

• MD, University of Missouri-Columbia School of Medicine, 1975

• Internal Medicine, St. Louis University (Missouri), 1975-1976
• Internal Medicine, University of Missouri, 1976-1977
• Dermatology, University of Missouri, 1977-1978
• Dermatology, Johns Hopkins University (Maryland), 1981-1982

• Dermatology Branch, NIH (Maryland), 1978-1981

Clinical Interests:
Immunologically mediated skin diseases, blistering skin diseases (dermatitis herpetiformis, bullous pemphigoid, pemphigus, cicatricial pemphigoid), immunofluorescence testing

Research Interests:
                               
Our laboratory is investigating the pathogenesis of autoimmune blistering skin diseases.  Areas of special expertise include immune mediated skin diseases, especially immune mediated primary blistering disorders. These include pathogenesis, diagnosis, and management.
Specifically our laboratory is investigating the role of the mucosal immune response in the pathogenesis of dermatitis herpetiformis (DH) and the role the associated gluten sensitive enteropathy (GSE) plays in the development of this disease.  Studies are currently focused on understanding the systemic manifestations of the mucosal immune response to dietary ingestion of wheat proteins in patients with DH.  Studies are directed at determining the pattern of cytokine activation and inflammatory cell activation in the gut, skin and circulation.   These studies are focused on understanding the manner in which gastrointestinal inflammation leads to the development of  skin lesions in patients with DH and will provide new insight into the pathogenesis of the numerous  skin diseases  associated with inflammatory gastrointestinal disease.    
In addition, our laboratory is investigating the pathogenesis of the  organ specific auto immune blistering diseases bullous pemphigoid, and pemphigus vulgaris.  These studies are directed at understanding auto-antibody epitopes and their relationship to disease activity and the role of B cells in the development and maintaince of auto-antibodies. Clinical trials are ongoing in both pemphigus and bullous pemphigoid that are coupled with mechanistic studies.

Representative Publications:
Suarez EC, Boyle SH, Lewis JG, Hall RP, Young KH. Increases in stimulated secretion of proinflammatory cytokines by blood monocytes following arousal of negative affect: The role of insulin resistance as moderator. Brain Behav Immun. 2006 Jul;20(4):331-8. (2006) Abstract

Hall RP 3rd, Takeuchi F, Benbenisty KM, Streilein RD. Cutaneous endothelial cell activation in normal skin of patients with dermatitis herpetiformis associated with increased serum levels of IL-8, sE-Selectin, and TNF-alpha. J Invest Dermatol. 2006 Jun;126(6):1331-7. (2006) Abstract

Kong HH, Prose NS, Ware RE, Hall RP 3rd. Successful treatment of refractory childhood pemphgus vulgaris with anti-CD20 monoclonal antibody (rituximab). Pediatr Dermatol. 2005 Sep-Oct;22(5):461-4. (2005) Abstract

Whited JD, Hall RP, Foy ME, Marbrey LE, Grambow SC, Dudley TK, Datta SK, Simel DL, Oddone EZ. Patient and clinician satisfaction with a store-and-forward teledermatology consult system. Telemed J E Health. 2004;10(4):422-31. (2004) Abstract

Takeuchi F, Sterilein RD, Hall RP 3rd. Increased E-selectin, IL-8 and IL-10 gene expression in human skin after minimal trauma. Exp Dermatol. 2003 Dec;12(6):777-83. (2003) Abstract

Szabolcs P, Reese M, Yancey KB, Hall RP, Kurtzberg J. Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease. Bone Marrow Transplant. 2002 Sep;30(5):327-9. (2002) Abstract

Smith AD, Streilein RD, Hall RP. Neutrophil CD11b, L-selectin and Fc IgA receptors in patients with dermatitis herpetiformis. Br J Dermatol. 2002 Dec;147(6):1109-17. (2002) Abstract

Hall RP. Linear IgA dermatosis and chronic bullous disease of childhood in Fitzpatrick's Dermatology in General Medicine, Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, Fitzpatrick TB, (eds), McGraw-Hill 680-685,1999. (2001)

Hall RP, Bullous diseases of the skin and mucous membranes in Clinical Immunology Principles and Practice, Rich RR, Fleisher TA, Shearer WT, Kotzin BL, Schroeder Jr HW, (eds), Mosby,75.1-75.18, 2001. (2001)

Bagheri B, Hall RP. Dermatitis Herpetiformis in Atlas of Bullous Disease, RE Jordon editor, Churchill Livingstone, 99-107, 2000. (2001)

Roh JY, Yee C, Lazarova Z, Hall RP, Yancey KB. The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis. Br J Dermatol. 2000 Jul;143(1):104-11. (2000) Abstract

Hall RP, Smith AD, Streilein RD. Increased production of IL-4 by T cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten sensitive enteropathy. Dig Dis Sci 45: 2036-2043, 2000. (2000)

Hall RP 3rd, Smith AD, Streilein RD. Increased production of IL-4 by gut T-cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten-sensitive enteropathy. Dig Dis Sci. 2000 Oct;45(10):2036-43. (2000) Abstract

Hall RP 3rd, Owen S, Smith A, Keough M, Bagheri B, Church P, Streilein R. TCR Vbeta expression in the small bowel of patients with dermatitis herpetiformis and gluten sensitive enteropathy. Limited expression in dermatitis herpetiformis and treated asymptomatic gluten sensitive enteropathy. Exp Dermatol. 2000 Aug;9(4):275-82. (2000) Abstract

Smith AD, Bagheri B, Streilein RD, Hall RP 3rd. Expression of interleukin-4 and interferon-gamma in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy. Dig Dis Sci. 1999 Oct;44(10):2124-32. (1999) Abstract

Rico MJ, Benning C, Weingart ES, Streilein RD, Hall RP III. Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris. Br J Dermatol. 1999 Jun;140(6):1079-86. (1999) Abstract

Ishii K, Amagai M, Hall RP, Hashimoto T, Takayanagi A, Gamou S, Shimizu N, Nishikawa T. Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. J Immunol. 1997 Aug 15;159(4):2010-7. (1997) Abstract

Rico MJ, Hashimototo T, Watanabe K, Hall RP, Clark RB, Nishikawa T. Comparative epitope mapping of sera from United States (US) and Japanese patients with bullous pemphigoid (BP) to fusion proteins encoded by BPAG1. J Dermatol Sci. 1996 Sep;12(3):238-45. (1996) Abstract