Page A. W. Anderson, MD

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Services

• Pediatric Cardiology

Department / Division:
Pediatrics / Cardiology

Address:
DUMC 3218
Durham, NC 27710

Appointment Telephone:
(919) 668-4000

Office Telephone:
(919) 684-6027

Fax Telephone:
(919) 684-4609

• M.D., Duke University School of Medicine, North Carolina, 1963

• Pediatrics, Children's Hospital, Los Angeles, California, 1968-1970

• Pediatric Cardiology, Duke University Medical Center, North Carolina, 1964, 1970-1973

Clinical Interests:
Structural and acquired heart disease in the infant, child, adolescent, and young adult

Research Interests:
Areas of research interests (basic and applied):

Dr. Anderson's research interests can be described generally as related to the heart and the cardiovascular system.  His research is in the areas of clinical, translational, and basic science.  Heis the Principal Investigator of a Center in teh NHLBI-funded Pediatric Heart Network.  The Center carries out studies and trials that include subjects with complex congenital heart disease, Kawasaki Disease, and Marfans.  His translational research presently focues on developing therapies for the post-cardiopulmonary bypass syndrome.  Maturation is used as a mechanism to study the basis of the systems that control cardiac function.  The finding of our laboratory that a complement inhibitor, soluble complement receptor-1,  palliates the post-cardiopulmonary bypass syndrome in neonatal pigs lead to a Phase I/II trial in infants undergoing cardiac surgery requiring cardiopulmonary bypass and planned studies at a fundamental level in the laboratory.  His laboratory has identified other potential therapies for this syndrome.  The areas of basic research include the control of cytosolic calcium concentration and sarcomere dynamics in isolated ventricular myocytes, the expression of thin filament regulatory proteins and the functional significance of heterogeneity in isoform expression, regulation of myofilament sensitivity to calcium concentration, and the relationships between the expression of membrane proteins that control cell calcium and the contractile proteins that respond to changes in cell calcium.  His laboratory is studying stem cell biology.  The laboratory demonstrated that a stem cell line cloned from the liver of an adult rat liver differentiates into myocytes in vivo and ex vivo.  These studies are examining the mechanisms that regulate this process

Representative Publications:
Lounes KC, Demeler B, Anderson DE, Gomes AW, Potter JD, Nassar R, Anderson PA. Cardiac troponin T forms a tetramer in vitro. Biochemistry. 2008 Feb 19;47(7):1970-6. (2008) Abstract

Anderson PAW, Sleeper LA, Mahoney L, Colan SD, Atz AM, Breitbart RE, Gersony WM, Gallagher D, Geva T, Margossian R, McCrindle BW, Paridon S, Schwartz M, Stylianou M, Williams RV, Clark III, BJ, for the Pediatric Heart Network Investigators. Comtemporary Outcomes after the Fontan Procedure: A Pediatric Heart Network Multicenter Study.  J Am Coll Cardiol 2008 (In press) (2008)

Muller-Borer BJ, Cascio WE, Esch GL, Kim HS, Coleman WB, Grisham JW, Anderson PA, Malouf NN. Mechanisms controlling the acquisition of a cardiac phenotype by liver stem cells. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3877-82. (2007) Abstract

Baig K, Nassar R, Craig DM, Quick G Jr, Jiang HX, Frank MM, Lodge AJ, Anderson PA, Jaggers J. Complement factor 1 inhibitor improves cardiopulmonary function in neonatal cardiopulmonary bypass. Ann Thorac Surg. 2007 Apr;83(4):1477-82; discussion 1483. (2007) Abstract

Anderson PA, Muller-Borer BJ, Esch GL, Coleman WB, Grisham JW, Malouf NN. Calcium signals induce liver stem cells to acquire a cardiac phenotype. Cell Cycle. 2007 Jul 1;6(13):1565-9. (2007) Abstract

McCall SJ, Nassar R, Malouf NN, Saunders AJ, Oakeley AE, Henderson PM, Solaro RJ, Pielak GJ, Alexander KA, Anderson PA. Development and cardiac contractility: cardiac troponin T isoforms and cytosolic calcium in rabbit. Pediatr Res. 2006 Sep;60(3):276-81. (2006) Abstract

Lynn A. Sleeper, Sc.D.1, Page Anderson, M.D.2, Daphne T. Hsu, M.D.3, Lynn Mahony, M.D.4, Brian W. McCrindle, M.D., M.P.H. 5, Steven J. Roth, M.D.6, J. Phillip Saul, M.D. 7, Richard V. Williams, M.D.8, Tal Geva, MD9, Steven D. Colan, MD9, Bernard J. Clark, M.D.  for the Pediatric Heart Network Investigators.  Design of A Large Cross-Sectional Study to Facilitate Future Clinical Trials in Children With the Fontan Palliation.  Am Heart J. 2006;152:427-433. (2006)

Nassar R, Malouf NN, Mao L, Rockman HA, Oakeley AE, Frye JR, Herlong JR, Sanders SP, Anderson PA. cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform. Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1147-56. (2005) Abstract

Muller-Borer BJ, Cascio WE, Anderson PA, Snowwaert JN, Frye JR, Desai N, Esch GL, Brackham JA, Bagnell CR, Coleman WB, Grisham JW, Malouf NN. Adult-derived liver stem cells acquire a cardiomyocyte structural and functional phenotype ex vivo. Am J Pathol. 2004 Jul;165(1):135-45. (2004) Abstract

Li JS, Sanders SP, Perry AE, Stinnett SS, Jaggers J, Bokesch P, Reynolds L, Nassar R, Anderson PA. Pharmacokinetics and safety of TP10, soluble complement receptor 1, in infants undergoing cardiopulmonary bypass. Am Heart J. 2004 Jan;147(1):173-80. (2004) Abstract

Malouf NN, Coleman WB, Grisham JW, Lininger RA, Madden VJ, Sproul M, Anderson PA. Adult-derived stem cells from the liver become myocytes in the heart in vivo. Am J Pathol. 2001 Jun;158(6):1929-35. (2001) Abstract

Q & A with Page Anderson, MD