John R. Guyton, MD

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Services

• Endocrinology
• General and Consultative Heart Care

Department / Division:
Medicine / Endocrinology, Metabolism, and Nutrition

Address:
DUMC 3510
Durham, NC 27710

Appointment Telephone:
(919) 668-7630

Office Telephone:
(919) 684-9036

Fax Telephone:
(919) 681-7796

• M.D., Harvard Medical School, Massachusetts, 1973

• Medicine, University of Texas Southwestern Hospitals, 1973-1976
• Pathology, Diabetes Research, Endocrinology, Harvard Medical School, Massachusetts

Clinical Interests:
Focus on lipid disorders (cholesterol and triglyceride), metabolic syndrome, coronary prevention, atherosclerosis regression

Research Interests:

Research efforts are increasingly directed toward clinical lipid studies.  Significant challenges are (1) the development of sophisticated clinical lipoprotein analysis at Duke and (2) the collaborative design of trials with cardiovascular endpoints.  Minor effort is given to ongoing work in cerebrospinal fluid lipoproteins in collaboration with Warren Strittmatter.

Dr. Guyton is substantially involved as a consultant and lead investigator in clinical trials with Niaspan, an extended-release niacin preparation.  A recent  paper details long-term safety and absence of hepatic enzyme elevations with this preparation.  A current trial compares Niaspan with gemfibrozil for increasing HDL.  In addition, analyses of lipid results with niacin-statin combined regimens in the Duke Lipid Clinic and with dietary change in the Rice Diet Program are proceeding.

Dr. Guyton is recognized nationally as an expert in clinical management of lipid disorders and a leader in postgraduate education in this area.  Both nationally and internationally, Dr. Guyton is known for his work on lipid deposition in the arterial wall.

Key words:  atherosclerosis, lipoproteins, statins, niacin, triglycerides, low density lipoproteins, high density lipoproteins, apolipoprotein E

Representative Publications:
Guyton, J.R., Miller, S.E., Martin, M.E., Khan, W.A., Roses, A.D., Strittmatter, W.J. Novel large apolipoprotein E-containing lipoproteins of density 1.006-1.060 g/ml in human cerebrospinal fluid. Journal of Neurochemistry, 70:1235-1240,1998 (1998)

Guyton, J.R., Goldberg, A.C., Kreisberg, R.A., Sprecher, D.L., Superko, H.R., O'Connor, C.M. Once nightly dosing of extended-release niacin (Niaspan) for hypercholesterolemia: long-term use alone and in combination therapy. American Journal of Cardiology,82:737-743, 1998 (1998)

Thompson, P.D., Zmuda, J.M., Domalik, L.J., Zimet, R.J., Staggers, J., Guyton, J.R. Lovastatin increases exercise-induced skeletal muscle injury. Metabolism 46:1206-1210, 1997. (1997)

Guyton, J.R. Lipid metabolism and atherogenesis. In: The Science and Practice of Pediatric Cardiology, eds. Garson, A., Jr., Bricker, J.T., Fisher, D.J., Neish, S.R., Williams and Wilkins, Baltimore, 1997, pp. 491-509. (1997)

Guyton, J.R., Klemp, K.F. Development of the lipid-rich core in human atherosclerosis. Arteriosclerosis Thrombosis & Vascular Biology 16:4-11, 1996. (1996)