Chief, Diagnostic Services

Department / Division:
Pathology / Pathology

Address:
DUMC 3712
Durham, NC 27710

Office Telephone:
919-684-3656

Fax Telephone:
919-684-3670

• MD, University of Michigan Medical School, 1965

• Pathology, Massachusetts General Hospital, Harvard Medical School, 1966-1970

Clinical Interests:
Gynecologic pathology

Research Interests:
My research program, largely histopathological, concerns definitions of criteria, biological properties, differential diagnosis, and survival associated with pathological lesions in the female genital tract.  With the gynecologic oncologists at Duke, we are reviewing the Institution's long term experience of endometrial cancer.  With the International Collaborative Group on Endometrium, we are evaluating a new classification system for endometrial hyperplasia. In a nationwide NIH study in which I head the pathology review, long term complications in both sons and daughters from prenatal exposure to DES are being assessed.   A major initiative is a study of vulvar dermatoses and unusual vulvar neoplasms. A final clinical pathologic correlation study, ongoing for over 20 years, has been the long term follow-up of a very rare tumor (malignant struma ovarii).  Long term study has been required to identify those features that will ultimately prove to be of biologic significance for defining cases which will likely recur.

Representative Publications:
Robboy SJ, Mutter GS, Prat J, Bentley RC, Russell P, Anderson M: Pathology of the Female Reproductive Tract, Elsevier (Churchill Livingstone), London, Ed 2, 1045 pp, 2009.  (ISBN: 978-0-443-07477-6) (2009)

Maksem JA, Robboy SJ, Bishop JW, Meiers I: Endometrial Cytology with Tissue Correlations, Springer Verlag, In Press. (2009)

Yu L, Saile K, Swartz CD, He H, Zheng X, Kissling GE, Di X, Lucas S, Robboy SJ, Dixon D. Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. Mol Med. 2008 May-Jun;14(5-6):264-75. (2008) Abstract

Strohsnitter WC, Hatch EE, Hyer M, Troisi R, Kaufman RH, Robboy SJ, Palmer JR, Titus-Ernstoff L, Anderson D, Hoover RN, Noller KL. The association between in utero cigarette smoke exposure and age at menopause. Am J Epidemiol. 2008 Mar 15;167(6):727-33. (2008) Abstract

Kim KR, Park BH, Hong YO, Kwon HC, Robboy SJ. The Villous Stromal Constituents of Complete Hydatidiform Mole Differ Histologically in Very Early Pregnancy From the Normally Developing Placenta. Am J Surg Pathol. 2008 Oct 17. (2008) Abstract

Troisi R, Titus-Ernstoff L, Hyer M, Hatch EE, Robboy SJ, Strohsnitter W, Palmer JR, Øgloend B, Adam E, Kaufman R, Herbst AL, Hoover RN. Preeclampsia risk in women exposed in utero to diethylstilbestrol. Obstet Gynecol. 2007 Jul;110(1):113-20. (2007) Abstract

Troisi R, Hatch EE, Titus-Ernstoff L, Hyer M, Palmer JR, Robboy SJ, Strohsnitter WC, Kaufman R, Herbst AL, Hoover RN. Cancer risk in women prenatally exposed to diethylstilbestrol. Int J Cancer. 2007 Jul 15;121(2):356-60. (2007) Abstract

Robboy SJ, Jaubert F. Neoplasms and pathology of sexual developmental disorders (intersex). Pathology. 2007 Feb;39(1):147-63. (2007) Abstract

Mutter GL, Zaino RJ, Baak JP, Bentley RC, Robboy SJ. Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int J Gynecol Pathol. 2007 Apr;26(2):103-14. (2007) Abstract

Maksem JA, Meiers I, Robboy SJ. A primer of endometrial cytology with histological correlation. Diagn Cytopathol. 2007 Dec;35(12):817-44. (2007) Abstract

Snyder MJ, Bentley R, Robboy SJ. Transtubal spread of serous adenocarcinoma of the endometrium: an underrecognized mechanism of metastasis. Int J Gynecol Pathol. 2006 Apr;25(2):155-60. (2006) Abstract

Lagoo AS, Robboy SJ. Lymphoma of the female genital tract: current status. Int J Gynecol Pathol. 2006 Jan;25(1):1-21. (2006) Abstract

Baak JP, Kruse AJ, Robboy SJ, Janssen EA, van Diermen B, Skaland I. Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers. J Clin Pathol. 2006 Oct;59(10):1017-28. (2006) Abstract

Robboy SJ, Datto MB. Synchronous endometrial and ovarian tumors: metastatic disease or independent primaries? Hum Pathol. 2005 Jun;36(6):597-9. (2005) Abstract

Kurita T, Cunha GR, Robboy SJ, Mills AA, Medina RT. Differential expression of p63 isoforms in female reproductive organs. Mech Dev. 2005 Sep;122(9):1043-55. (2005) Abstract

Robboy SJ, Merino M, Kurman RT: The female reproductive system.  In: Rubin E, Farber J, ed.  Edition 4 Lippincott, Chpt 18,  in press. (2004)

Ozols R, Rubin SC, Thomas GM, Robboy SJ: Epithelial ovarian cancer. In: Gynecologic Oncology: Principles and Practice.  Ed: Hoskins WJ, Perez CA, Young RC. Lippincott, Williams & Wilkins, Pub.  Ed 4, in press. (2004)

Moore-Maxwell CA, Robboy SJ. Placental site trophoblastic tumor arising from antecedent molar pregnancy. Gynecol Oncol. 2004 Feb;92(2):708-12. (2004) Abstract

Moore-Maxwell CA, Robboy SJ. Mucinous adenocarcinoma arising in rectovaginal fistulas associated with Crohn's disease. Gynecol Oncol. 2004 Apr;93(1):266-8. (2004) Abstract

Kim KR, Peng R, Ro JY, Robboy SJ. A diagnostically useful histopathologic feature of endometrial polyp: the long axis of endometrial glands arranged parallel to surface epithelium. Am J Surg Pathol. 2004 Aug;28(8):1057-62. (2004) Abstract

Kruse AJ, Baak JP, Helliesen T, Kjellevold KH, Robboy SJ. Prognostic value and reproducibility of koilocytosis in cervical intraepithelial neoplasia. Int J Gynecol Pathol. 2003 Jul;22(3):236-9. (2003) Abstract

Robboy SJ:  Embryology of the female genital tract and disorders of abnormal sexual development.  In: Kurman RT, ed.  Blaustein's Pathology of the Female Genital Tract, 4th ed., New York: Springer Verlag,  2002 (2002)

Robboy SJ. Book review. Int J Gynecol Pathol. 2002 Apr;21(2):203-4. (2002) Abstract

Robboy SJ, Kraus FT, Kurman RJ:  Gross description, processing, and reporting of gynecologic and obstetric specimens. In: Kurman RT, ed.  Blaustein's Pathology of the Female Genital Tract, 4th ed., New York: Springer Verlag, 2002 (2002)

Robboy SJ, Bentley RC, Russell P: Pathology of Abnormal Sexual Development. In Haines & Taylor's Gynecological and Obstetrical Pathology. 5th Edition, Fox, H, Wells M, ed. Churchill Livingstone, London, in press. (2002)

Robboy SJ, Anderson M, Russell P.:  Pathology of the Female Genital Tract, Churchill Livingstone, London, March 2002 (929 pages, 2,000+ photographs). (2002)

Payne JF, Robboy SJ, Haney AF. Embolic microspheres within ovarian arterial vasculature after uterine artery embolization. Obstet Gynecol. 2002 Nov;100(5 Pt 1):883-6. (2002) Abstract

Dixon D, Flake GP, Moore AB, He H, Haseman JK, Risinger JI, Lancaster JM, Berchuck A, Barrett JC, Robboy SJ. Cell proliferation and apoptosis in human uterine leiomyomas and myometria. Virchows Arch. 2002 Jul;441(1):53-62. (2002) Abstract

Strohsnitter WC, Noller KL, Hoover RN, Robboy SJ, Palmer JR, Titus-Ernstoff L, Kaufman RH, Adam E, Herbst AL, Hatch EE. Cancer risk in men exposed in utero to diethylstilbestrol. J Natl Cancer Inst. 2001 Apr 4;93(7):545-51. (2001) Abstract

Stern RC, Dash R, Bentley RC, Snyder MJ, Haney AF, Robboy SJ. Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types. Int J Gynecol Pathol. 2001 Apr;20(2):133-9. (2001) Abstract

Robboy SJ. BOOK REVIEWS. Int J Gynecol Pathol. 2001 Jan;20(1):102. (2001) Abstract

Hatch EE, Herbst AL, Hoover RN, Noller KL, Adam E, Kaufman RH, Palmer JR, Titus-Ernstoff L, Hyer M, Hartge P, Robboy SJ. Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States). Cancer Causes Control. 2001 Nov;12(9):837-45. (2001) Abstract

Alvarez AA, Moore WF, Robboy SJ, Bentley RC, Gumbs C, Futreal PA, Berchuck A. K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary. Gynecol Oncol. 2001 Feb;80(2):201-6. (2001) Abstract

Robboy SJ, Norris HJ:  Atlas of Cervical Pathology. Ed 2. Intellipath, Chapman Hall, New York, NY 2000. (2000)

Robboy SJ, Bentley RC, Butnor K, Anderson MC. Pathology and pathophysiology of uterine smooth-muscle tumors. Environ Health Perspect. 2000 Oct;108 Suppl 5:779-84. (2000) Abstract

Prout GR Jr, Wesley MN, Greenberg RS, Chen VW, Brown CC, Miller AW, Weinstein RS, Robboy SJ, Haynes MA, Blacklow RS, Edwards BK. Bladder cancer: race differences in extent of disease at diagnosis. Cancer. 2000 Sep 15;89(6):1349-58. (2000) Abstract

Moore WF, Bentley RC, Berchuck A, Robboy SJ. Some mullerian inclusion cysts in lymph nodes may sometimes be metastases from serous borderline tumors of the ovary. Am J Surg Pathol. 2000 May;24(5):710-8. (2000) Abstract

Cirisano FD Jr, Robboy SJ, Dodge RK, Bentley RC, Krigman HR, Synan IS, Soper JT, Clarke-Pearson DL. The outcome of stage I-II clinically and surgically staged papillary serous and clear cell endometrial cancers when compared with endometrioid carcinoma. Gynecol Oncol. 2000 Apr;77(1):55-65. (2000) Abstract

Bentley R, Robboy SJ:  Interpretation of endometrial pathology with hormonal replacement therapy in postmenopausal women.  In:  Management of the Menopause: The Millenium Review 2000, JWW Studd, ed. Parthenon Pub. 2000: 255-256. (2000)