Virginia Byers Kraus, MD, PhD

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• Rheumatology and Immunology

Department / Division:
Medicine / Rheumatology and Immunology

Address:
DUMC 3416
Durham, NC 27710

Appointment Telephone:
(919) 660-6610

Office Telephone:
(919) 681-6652

Fax Telephone:
(919) 684-8907

• M.D., Duke University School of Medicine, North Carolina, 1982

• Medicine, Duke University Medical Center, North Carolina, 1983-1986

• Rheumatology, Duke University Medical Center, North Carolina, 1986-1990

• Ph.D., Duke University School of Medicine, North Carolina, 1993

Clinical Interests:
Diagnosis, treatment and the study of hereditary forms of osteoarthritis; exercise rehabilitation for arthritis; clinical trials for osteoarthritis of new therapeutics

Research Interests:
   My special area of expertise is as a clinician scientist investigating osteoarthritis.  Osteoarthritis is the most common form of joint disease in man and its incidence increases with age.  It is a problem of increasing concern to the medical community due to the increasing longevity of the population.  Trained as a molecular biologist and  a Rheumatologist, I endeavor to study this disease from bedside to bench.  

The work in this laboratory  focuses on osteoarthritis and deals with the mechanisms of joint damage, the discovery of novel biochemical and genetic biomarkers for minimally invasive means of monitoring disease predisposition and severity, and development of approaches to enhance cartilage viability in tissue engineering applications.   As Chairperson on the NIH funded Osteoarthritis Biomarkers Network, I am excited about the prospects for discovery of novel diagnotics and therapeutics for osteoarthritis during this decade, declared by the WHO to be the Decade of the Bone and Joint.  


key words:  osteoarthritis, proteomics, arthritis, biological markers, molecular pathogenesis, human genetics

Representative Publications:
Kraus VB, Huebner JL, Fink C, King JB, Brown S, Vail TP, Guilak F. Urea as a passive transport marker for arthritis biomarker studies. Arthritis Rheum. 2002 Feb;46(2):420-7. (2002) Abstract

Clark AG, Rohrbaugh AL, Otterness I, Kraus VB. The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. Matrix Biol. 2002 Mar;21(2):175-84. (2002) Abstract

Huebner JL, Hanes MA, Beekman B, TeKoppele JM, Kraus VB. A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis. Osteoarthritis Cartilage. 2002 Oct;10(10):758-67. (2002) Abstract

Criscione LG, Elliott AL, Stabler T, Jordan JM, Pieper CF, Kraus VB. Variation of serum hyaluronan with activity in individuals with knee osteoarthritis. Osteoarthritis Cartilage. 2005 Sep;13(9):837-40. (2005) Abstract

Kong SY, Stabler TV, Criscione LG, Elliott AL, Jordan JM, Kraus VB. Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis. Arthritis Rheum. 2006 Aug;54(8):2496-504. (2006) Abstract

Kraus VB. Do biochemical markers have a role in osteoarthritis diagnosis and treatment? Best Pract Res Clin Rheumatol. 2006 Feb;20(1):69-80. (2006) Abstract

Huebner JL, Kraus VB. Assessment of the utility of biomarkers of osteoarthritis in the guinea pig. Osteoarthritis Cartilage. 2006 Sep;14(9):923-30. (2006) Abstract

Bauer DC, Hunter DJ, Abramson SB, Attur M, Corr M, Felson D, Heinegård D, Jordan JM, Kepler TB, Lane NE, Saxne T, Tyree B, Kraus VB, . Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthritis Cartilage. 2006 Aug;14(8):723-7. (2006) Abstract

McCudden C and VB Kraus.  2006.  Biochemistry of amino acid racemization and clinical application to musculoskeletal disease.  Clinical Biochemistry (in press).   (2006)

Elliott AL, Kraus VB, Fang F, Renner JB, Schwartz TA, Salazar A, Huguenin T, Hochberg MC, Helmick CG, Jordan JM. Joint-specific hand symptoms and self-reported and performance-based functional status in African Americans and Caucasians: The Johnston County Osteoarthritis Project. Ann Rheum Dis. 2007 Dec;66(12):1622-6. (2007) Abstract

Kraus VB, Stabler TV, Luta G, Renner JB, Dragomir AD, Jordan JM. Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritis. Osteoarthritis Cartilage. 2007 Aug;15(8):966-71. (2007) Abstract

Kraus VB, Jordan JM, Doherty M, Wilson AG, Moskowitz R, Hochberg M, Loeser R, Hooper M, Renner JB, Crane MM, Hastie P, Sundseth S, Atif U. The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes. Osteoarthritis Cartilage. 2007 Feb;15(2):120-7. (2007) Abstract

Shamji MF, Betre H, Kraus VB, Chen J, Chilkoti A, Pichika R, Masuda K, Setton LA. Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. Arthritis Rheum. 2007 Nov;56(11):3650-61. (2007) Abstract

Kraus VB, Stabler TV, Kong SY, Varju G, McDaniel G. Measurement of synovial fluid volume using urea. Osteoarthritis Cartilage. 2007 Oct;15(10):1217-20. (2007) Abstract

Charles HC, Kraus VB, Ainslie M, Hellio Le Graverand-Gastineau MP. Optimization of the fixed-flexion knee radiograph. Osteoarthritis Cartilage. 2007 Nov;15(11):1221-4. (2007) Abstract

Huebner JL, Seifer DR, Kraus VB. A longitudinal analysis of serum cytokines in the Hartley guinea pig model of osteoarthritis. Osteoarthritis Cartilage. 2007 Mar;15(3):354-6. (2007) Abstract

Pells JJ, Shelby RA, Keefe FJ, Dixon KE, Blumenthal JA, Lacaille L, Tucker JM, Schmitt D, Caldwell DS, Kraus VB. Arthritis self-efficacy and self-efficacy for resisting eating: Relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee pain. Pain. 2007 Aug 29. (2007) Abstract

Allen KD, DeVellis RF, Renner JB, Kraus VB, Jordan JM. Validity and factor structure of the AUSCAN Osteoarthritis Hand Index in a community-based sample. Osteoarthritis Cartilage. 2007 Jul;15(7):830-6. (2007) Abstract

Birmingham, JD, V Vilim and VB Kraus.  2006.  Collagen biomarkers for arthritis applications.  Biomarker Insights 2:61-76 (http://www.la-press.com/biomark.html). (2006)