Carlos M. De Castro III, MD

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Services

• Bone and Soft Tissue Cancer
• Leukemias and Lymphomas

Department / Division:
Medicine / Medical Oncology

Address:
DUMC 3872
Durham, NC 27710

Appointment Telephone:
(919) 684-8964

Office Telephone:
(919) 684-8964

Fax Telephone:
(919) 684-5325

• M.D., University of Texas Southwestern Medical School, 1985

• Internal Medicine, Parkland Memorial Hospital, Texas, 1985-1988

• Hematology-Oncology, Duke University Medical Center, North Carolina, 1988-1991

Clinical Interests:
Hematopoietic disorders, acute leukemia, myelodysplastic syndromes, aplastic anemia, myeloproliferative disorders, anemia, general hematology and oncology, paroxysmal nocturnal hemoglobinuria

Research Interests:
Current basic research efforts are involved with studying the signal transduction pathway of the c-kit proto-oncogene in human hematopoiesis.  We are currently focusing on the role of a novel ets factor, PE-2 and its role in erythropoiesis.  Studies are also ongoing looking at the possible use of the c-kit receptor as a target for gene therapy into hematopoietic stem cells.

Clinical research projects have focused on new and innovative treatments for myelodysplastic syndromes, adult leukemias, and lymphomas

Representative Publications:
Vandenbark GR, de Castro CM, Taylor H, Dew-Knight S, Kaufman RE. Cloning and structural analysis of the human c-kit gene. Oncogene 7:1259-1266, 1992. (1992)

He J, de Castro CM, Vandenbark GR, Busciglio J, Gabuzda D. Astrocyte Apoptosis Induced by HIV-1 Transactivation of the c-kit proto-oncogene. Proc Natl Acad Sci USA 94: 3954-3959, 1997. (1997)

de Castro CM, Rabe SM, Langdon SD, Fleenor DE, Ahmed MN, Qumsiyeh MB, Kaufman RE. Genomic Structure and Chromosomal Localization of PE-2 (ERF), a novel ETS Factor with Potential Tumor Suppressor Properties. Genomics 42: 227-235, 1997. (1997)

Bowen DT, Padua RA, Burnett AK, de Castro CM, Kaufman RE. Two new polymorphisms but no mutations of the kit gene in patients with myelodysplasia at positions corresponding to human fms and murine W locus mutational hot spots. Leukemia 7:1883-1885, 1993. (1993)

de Castro CM, Devlin BH, Lee ME, Fleenor DE, Kaufman RE. A Novel b-globin Mutation, b Durham, N.C. [b 114 Leu-Pro], Detected by PCR-SSCP, Produces a Dominant Thalassemia-like Phenotype. Blood 83:1109-1116. 1994. (1994)

de Castro CM, Vandenbark GR, Langdon S, Denning SM, Kurtzberg J, Scearce R, Haynes BF, Kaufman RE. The Kit Proto-oncogene Receptor is Expressed on a Subset of Human CD3-, CD4-, CD8- (Triple Negative) Thymocytes. Exp Hematol 22:1025-1033, 1994. (1994)

Vandenbark GR, Chen Y, Friday E, Pavlik K, Anthony B, de Castro C, Kaufman RE. Complex Regulation of Human c-kit Transcription by Promoter Repressors, Activators, and Specific myb Elements. Cell Growth Different 7:1383-1392, 1996. 6. Fleenor DE, Langdon SD, de Castro CM, Kaufman RE. Comparison of human and Xenopus GATA-2 promoters. Gene 179: 219-223, 1996. (1996)

Mann KP, de Castro CM, Liu J, Moore JO, Bigner S, Traweek ST. Neural cell adhesion molecule (CD56) positive acute myelogenous leukemia and myelodysplastic syndrome. Am J Clin Pathol 107: 653-660, 1997. 9. Wuebbens MW, Roush ED, de Castro CM, Fierke CA. Cloning, Sequencing, and Recombinant Expression of the Porcine Inhibitor of Carbonic Anhydrase: A Novel Member of the Transferrin Family. Biochemistry 36: 4327-4336, 1997. (1997)