M. Anthony Moody, MD

Department / Division:
Pediatrics / Infectious Diseases

Address:
DUMC 3499
Durham, NC 27710

Appointment Telephone:
919-668-4000

Office Telephone:
919-684-6335

• MD, Duke University School of Medicine, 1999

• Categorical Pediatrics, Emory University School of Medicine (Georgia), 1999-2002
• Pediatrics, Chief Resident, Emory University School of Medicine (Georgia), 2002-2003

• Pediatric Infectious Diseases, Duke University School of Medicine, 2003-2006

Clinical Interests:
General pediatric infectious diseases, pediatric tuberculosis, sexually transmitted infections

Research Interests:
My current research is in three related areas.

First, I am developing tools for the analysis of B cells so that we can identify and characterize B cells in a variety of scenarios including HIV infection, autoimmune disease, and animal models of vaccination. For this work I employ many chemical and purification techniques.

Second, I am developing flow cytometric panels to characterize human B cells that are obtained from various clinical and animal protocols. The purpose of this work is to determine what alterations in B cell profile exist in acute and chronic HIV infection, in autoimmune disease, and in animal vaccine models.

Third, I am director of several clinical protocols for the Center for HIV/AIDS Vaccine Immunology (CHAVI) aimed at recruiting autoimmune patients, patients who are infected or might have been exposed to HIV-1, and healthy controls to investigate the role of autoimmune diseases and other factors in the ability to make broadly reactive antibodies against HIV-1 or to control HIV-1 infection.

Representative Publications:
Alam SM, Scearce RM, Parks RJ, Plonk K, Plonk SG, Sutherland LL, Gorny MK, Zolla-Pazner S, Vanleeuwen S, Moody MA, Xia SM, Montefiori DC, Tomaras GD, Weinhold KJ, Karim SA, Hicks CB, Liao HX, Robinson J, Shaw GM, Haynes BF. Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection. J Virol. 2008 Jan;82(1):115-25. (2008) Abstract

Lenfestey RW, Smith PB, Moody MA, Clark RH, Cotten CM, Seed PC, Benjamin DK Jr. Predictive value of cerebrospinal fluid parameters in neonates with intraventricular drainage devices. J Neurosurg. 2007 Sep;107(3 Suppl):209-12. (2007) Abstract

Smith PB, Cotten CM, Garges HP, Tiffany KF, Lenfestey RW, Moody MA, Li JS, Benjamin DK Jr. A comparison of neonatal Gram-negative rod and Gram-positive cocci meningitis. J Perinatol. 2006 Feb;26(2):111-4. (2006) Abstract

Garges HP, Moody MA, Cotten CM, Smith PB, Tiffany KF, Lenfestey R, Li JS, Fowler VG Jr, Benjamin DK Jr. Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters? Pediatrics. 2006 Apr;117(4):1094-100. (2006) Abstract

Haynes BF, Moody MA, Verkoczy L, Kelsoe G, Alam SM. Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Hum Antibodies. 2005;14(3-4):59-67. (2005) Abstract

Haynes BF, Moody MA, Heinley CS, Korber B, Millard WA, Scearce RM. HIV type 1 V3 region primer-induced antibody suppression is overcome by administration of C4-V3 peptides as a polyvalent immunogen. AIDS Res Hum Retroviruses. 1995 Feb;11(2):211-21. (1995) Abstract