Carol S. Dukes Hamilton, MD, MHS

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Services

• AIDS Research and Treatment Center (DART)
• Infectious Diseases

Department / Division:
Medicine / Infectious Diseases and International Health

Address:
DUMC 3306
Durham, NC 27710

Appointment Telephone:
919-668-7630

Fax Telephone:
919-479-2948

• MD, University of Utah School of Medicine, 1985

• Medicine, Duke University Medical Center, 1988

• Infectious Diseases, Duke University Medical Center, 1991

• MHS, Duke University, 2007

Clinical Interests:
Treatment, prevention, and public health aspects of tuberculosis (TB), pulmonary MAC/MAI, HIV/AIDS in adults

Research Interests:
Dr. Carol Dukes Hamilton is an Infectious Diseases-trained Associate Professor of Medicine, whose research program focus is to optimize strategies to cure and prevent development of tuberculosis (TB).  She has a special interest in TB in HIV-infected individuals and her clinical outpatient work is largely comprised of patients with HIV/AIDS.  She is actively involved in both clinical trials and epidemiologic studies.  She currently has independent research support and has a history of consistent research support over the years from the NHLBI, NIAID, NIEHS, the VA Career Development Program, and the U.S. Centers for Disease Control and Prevention (CDC).  Dr. Hamilton has taken numerous opportunities to practice medicine and perform clinical research in resource-poor countries.  She spent 8-16 week stints in rural Zimbabwe (1987), in urban Tanzania (1989), and as a visiting professor in urban Saudi Arabia (1995).  In Dar es Salaam, Tanzania, she studied adults presenting to hospital with pericardial effusions, proving that the effusions were caused by TB associated with HIV/AIDS (2).  She also helped investigate the microbial etiology of chronic diarrhea in HIV-infected children (3) and also published their experience of seeing increasing and severe cutaneous reactions to common anti-TB medications in patients with underlying HIV infection (4).  In 1995, Dr. Hamilton and other VA investigators began a multi-center TB trial of a new drug, rifapentine.  The investigator-driven consortium resulting from the rifapentine trial (Study 22) became known as the TB Trials Consortium.  The Consortium provided a base from which Dr. Hamilton’s other TB activities have grown.  She and a colleague studied disseminated MAC in Duke HIV clinic patients before and after availability of highly active antiretroviral therapy (HAART) (17). In 2001 became the Medical Director of the North Carolina TB Control Program.  Her role in the statewide public health management of TB activities enhances her work with other public health-oriented TB specialists in the U.S. and internationally.  It also provides outstanding opportunities for epidemiologic and programmatic research for her and her trainees. More recently, Dr. Hamilton has used the State’s TB Control program as the basis for a collaboration with colleagues at the Duke Center for Human Genetics.  They successfully competed for an NHLBI R01 to support collection of DNA from North and South Carolina patients who have had proven pulmonary TB.   Dr. Hamilton and her genetic epidemiologist collaborator, Dr. William Scott, will use their combined expertise in clinical, molecular, and epidemiological sciences to investigate candidate genes that may contribute to human susceptibility to TB.  Dr. Hamilton is currently leading a study of TB diagnostic strategies in Moshi, Tanzania, funded by the NIH ISAAC project.


Key words: Tuberculosis; mycobacteria other than TB (MOTT); HIV/AIDS;  HAART; genomics; international health; public health;

Representative Publications:
Stout JE, Saharia KK, Nageswaran S, Ahmed A, Hamilton CD. Racial and ethnic disparities in pediatric tuberculosis in North Carolina. Arch Pediatr Adolesc Med. 2006 Jun;160(6):631-7. (2006) Abstract

Stout JE, Ostbye T, Walter EB, Hamilton CD. Tuberculosis knowledge and attitudes among physicians who treat young children in North Carolina, USA. Int J Tuberc Lung Dis. 2006 Jul;10(7):783-8. (2006) Abstract

Glickman SW, Rasiel EB, Hamilton CD, Kubataev A, Schulman KA. Medicine. A portfolio model of drug development for tuberculosis. Science. 2006 Mar 3;311(5765):1246-7. (2006) Abstract

Hamilton CD. Immunosuppression related to collagen-vascular disease or its treatment. Proc Am Thorac Soc. 2005;2(5):456-60. (2005) Abstract

Frothingham R, Stout JE, Hamilton CD. Current issues in global tuberculosis control. Int J Infect Dis. 2005 Nov;9(6):297-311. (2005) Abstract

Hamilton CD. Infectious complications of treatment with biologic agents. Curr Opin Rheumatol. 2004 Jul;16(4):393-8. (2004) Abstract

Weiner M, Burman W, Vernon A, Benator D, Peloquin CA, Khan A, Weis S, King B, Shah N, Hodge T, for the Tuberculosis Trials Consortium. Low isoniazid concentrations and outcome of tuberculosis treatment with once-weekly isoniazid and rifapentine.  Am J Resp & Crit Care Med, 2003;167:1341-7. (2003)

Stout JE, Engemann JJ, Cheng ACS, Fortenberry ER, Hamilton CD.  Safety of 2 months of rifampin and pyrazinamide for treatment of latent tuberculosis.  Am J Resp Crit Care Med.167:824-827, 2003 (accompanied by an editorial, 167:809-812). (2003)

Burman W, Breese P, Weis S, Bock N, Bernardo J, Vernon A, and the Tuberculosis Trials Consortium.  The effects of local review on informed consent documents from a multicenter clinical trials consortium.  Controlled Clinical Trials 24:245-255, 2003. (2003)

Tuberculosis Trials Consortium.  Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial. Lancet 360:528-34, 2002 (2002)

Stout JE, Ratard R, Southwick KL, Hamilton CD. Epidemiology of human immunodeficiency virus testing among patients with tuberculosis in North Carolina. South Med J. 2002 Feb;95(2):231-8. (2002) Abstract

Stout JE, Lai JC, Giner J, Hamilton CD. Reactivation of retinal toxoplasmosis despite evidence of immune response to highly active antiretroviral therapy. Clin Infect Dis. 2002 Aug 15;35(4):e37-9. (2002) Abstract

Stout JE, Engemann JJ, Cheng AC, Fortenberry ER, Hamilton CD. Safety of 2 months of rifampin and pyrazinamide for treatment of latent tuberculosis. Am J Respir Crit Care Med. 2002 Nov 21;():. (2002) Abstract

Bock NN, Sterling TR, Hamilton CD, Pachucki C, Wang YC, Conwell DS, Mosher A, Samuels M, Vernon A, . A prospective, randomized, double-blind study of the tolerability of rifapentine 600, 900, and 1,200 mg plus isoniazid in the continuation phase of tuberculosis treatment. Am J Respir Crit Care Med. 2002 Jun 1;165(11):1526-30. (2002) Abstract

Robbins WA, Witt KL, Haseman JK, Dunson DB, Troiani L, Cohen MS, Hamilton CD, Perreault SD, Libbus B, Beyler SA, Raburn DJ, Tedder ST, Shelby MD, Bishop JB. Antiretroviral therapy effects on genetic and morphologic end points in lymphocytes and sperm of men with human immunodeficiency virus infection. J Infect Dis. 2001 Jul 15;184(2):127-35. (2001) Abstract

Johnson VA, Petropoulos CJ, Woods CR, Hazelwood JD, Parkin NT, Hamilton CD, Fiscus SA. Vertical transmission of multidrug-resistant human immunodeficiency virus type 1 (HIV-1) and continued evolution of drug resistance in an HIV-1-infected infant. J Infect Dis. 2001 Jun 1;183(11):1688-93. (2001) Abstract

Alexander BD, Stout JE, Reller LB, Hamilton CD. Hospital management of tuberculosis in a region with a low incidence of tuberculosis and a high prevalence of nontuberculous mycobacteria. Infect Control Hosp Epidemiol. 2001 Nov;22(11):715-7. (2001) Abstract

Hamilton CD, Drew R, Janning SW, Latour JK, Hayward S. Excessive use of vancomycin: a successful intervention strategy at an academic medical center. Infect Control Hosp Epidemiol. 2000 Jan;21(1):42-5. (2000) Abstract

Boggess KA, Myers ER, Hamilton CD. Antepartum or postpartum isoniazid treatment of latent tuberculosis infection. Obstet Gynecol. 2000 Nov;96(5 Pt 1):757-62. (2000) Abstract

Hamilton CD.  Tuberculosis.  In: Pleuropulmonary and Bronchial Infections, Simberkoff MS Section Editor, Current Infectious Disease Reports, (Editor: Mandell GL), Current Science Group, Philadelphia, PA, 1999. (1999)