David B. MacLeod, MB BS

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• Anesthesiology

Department / Division:
Anesthesiology / Anesthesiology

Address:
DUMC 3094
Durham, NC 27710

Office Telephone:
(919) 681-6437

Fax Telephone:
(919) 681-8994

• M.B., B.S., London, 1987

• Royal Naval Hospital, Portsmouth, U.K., 1989-1996
• Specialist Registrar, Southampton University Hospital, U.K., 1996-1998

• FRCA, Fellow Royal College of Anesthetist, U.K., 1996

Clinical Interests:
Regional anesthesiology, general anesthesiology, pulse oximetry, ultrasound, placement of central venous catheters and nerve blocks

Research Interests:
Education and Regional Anesthesia
My principal clinical interest is the use of peripheral nerve blocks and the development of novel techniques to improve resident training. I have designed and launched a website (www.regionalABC.org) dedicated to lower extremity nerve blocks. This valuable resource is available to all clinicians in the operating room and in the pre-operative block area.  It can be accessed by residents for learning and review whilst faculty can use the diagrams and clinical photographs to illustrate particular teaching points at the bedside. I am the co-director of the Carolina Cadaver Course, which is run annually in conjunction with Wake Forest University School of Medicine.
I am also actively involved in teaching the use of ultrasound for the placement of peripheral nerve blocks.  I have lectured on several national courses.

Human Pharmacology Lab (HPL)
I am the Director of the HPL which is a Phase 1 research unit.  The unit's members consist of clinical faculty with clinical interest across the spectrum of anesthesia.  This year the HPL has completed the pharmacokinetic profile of a novel drug delivery device for inhaled fentanyl, which is currently under review by the FDA. We have started further volunteer and clinical studies of a new cerebral oximeter.  The study group is about to embark upon a study to determine if dexmedetomidine confers the effect of restorative sleep upon postop surgical patients.

Representative Publications:
MacLeod D, Breslin D, Hardman D, D'Ercole F.  The ABC of Regional Anesthesia.  International Monitor Regional Anaesthesia and Pain Therapy 2002; 14(2):109. (2002)

Cortinez LI, Hsu YW, Sum-Ping ST, Young C, Keifer JC, Macleod D, Robertson KM, Wright DR, Moretti EW, Somma J. Dexmedetomidine Pharmacodynamics: Part II: Crossover Comparison of the Analgesic Effect of Dexmedetomidine and Remifentanil in Healthy Volunteers.  Anesthesiology.  2004 11;101(5):1077-1083. (2004) Abstract

Martin G, Lineberger CK, MacLeod DB, El-Moalem HE, Breslin DS, Hardman D, D'Ercole F. A new teaching model for resident training in regional anesthesia.  Anesth Analg.  2002 Nov;95(5):1423-7, table of contents. (2002) Abstract

Hsu YW, Cortinez LI, Robertson KM, Keifer JC, Sum-Ping ST, Moretti EW, Young CC, Wright DR, Macleod DB, Somma J. Dexmedetomidine Pharmacodynamics: Part I: Crossover Comparison of the Respiratory Effects of Dexmedetomidine and Remifentanil in Healthy Volunteers.  Anesthesiology.  2004 11;101(5):1066-1076. (2004) Abstract

MacLeod D, Cortinez L, Keifer J, Radulescu L, Somma J. Pulse oximeter response profiles under hypoxic and hypothermic conditions.  Anesthesiology 2003; 97:A623. (2003)

MacLeod DB, Cortinez LI, Keifer JC, Cameron D, Wright DR, White WD, Moretti EW, Radulescu LR, Somma J. The desaturation response time of finger pulse oximeters during mild hypothermia.  Anaesthesia.  2005 Jan;60(1):65-71. (2005) Abstract

Cortinez LI, Somma J, Robertson KM, Keifer JC, Wright DR, Hsu YW, MacLeod DB, Moretti EW. Changes in hematocrit based on incremental blood sampling: mathematical models perform poorly.  Can J Anaesth.  2005 Apr;52(4):374-8. (2005) Abstract

MacLeod D, Ikeda K, Keifer J, Grant S, Breslin D, Martin G.  The relative delay of pulse oximeter saturation to arterial oxygen saturation during hypoxia under different conditions. IARS 80th Clinical and Scientific Congress.  Anesth Analg 2006;102:S-142. (2006)

MacLeod D, Ikeda K, Keifer J, Moretti E, Ames W.  Validation of the CAS adult cerebral oximeter during hypoxia in healthy volunteers.  IARS 80th Clinical and Scientific Congress.  Anesth Analg 2006;102:S-162. (2006)

MacLeod D, Houghton WC, Cassella, JV, Ikeda K, Gan TJ. Pharmacokinetic profile of multiple doses of fentanyl delivered by inhaled thermal aerosol route.  Anesthesiology 2007: asaabstracts.com; A1092. (2007)

MacLeod D, Spyker DA, Habib A, Ho KY, Gan TJ. Pharmacodynamic response to fentanyl delivered by intravenous and inhaled thermal aerosol routes. Anesthesiology 2007: asaabstracts.com; A1093. (2007)

MacLeod D, Spyker DA , Houghton WC, Ikeda K, Gan TJ. Pharmacokinetic profiles of fentanyl delivered by intravenous and inhaled thermal aerosol routes. Anesthesiology 2007: asaabstracts.com; A733. (2007)

MacLeod D, Cassella, JV, Moretti E, Keifer JC, Gan TJ. Pharmacodynamic response to multiple doses of fentanyl delivered by inhaled thermal aerosol route. Anesthesiology 2007: asaabstracts.com; A1242. (2007)