Neil R. MacIntyre, MD

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Services

• Emergency Services
• Pulmonology and Respiratory Medicine

Chief, Clinical Services

Department / Division:
Medicine / Pulmonary, Allergy, and Critical Care

Address:
DUMC 3911
Durham, NC 27710

Appointment Telephone:
(919) 681-2720

Office Telephone:
(919) 681-2720

Fax Telephone:
(919) 681-2892

• M.D., Cornell University Medical School, New York, 1972

• Internal Medicine, Cornell-New York Hospital, 1973-1975

• Pulmonary, University of California at San Francisco, 1978-1981

Clinical Interests:
Pulmonary function testing, pulmonary rehabilitation, mechanical ventilation

Research Interests:
1)  Mechanical Ventilation and respiratory failure.  Current projects involve studying patient-ventilator interactions during modes of support that require patient activity.  The focus is on ventilatory muscle function during these assisted modes.  An additional new project will study the vasodilating properties of inhaled nitric oxide in patients receiving mechanical ventilation.  Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2)  Diffusing capacity of the lung for carbon monoxide.  Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung.

3)  Exercise in obstructive lung disease.  Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease.  Study subjects are patients undergoing the Duke Pulmonary Rehabilitation Program.

4)  Aerosol delivery systems.  The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways.

5)  Lung volume reduction surgery.  Duke is one of 18 institutions participating in a unique NIH-HCFA contract to perform a long term follow-up study of lung volume reduction surgery.

Representative Publications:
1) MacIntyre NR, Gropper C, Westfall T. Combining pressure limiting and volume cycling features in an interactive mechanical breath. Crit Care Med 22:353-357, 1994. (1994)

4) MacIntyre NR and Leatherman NE. Ventilatory muscle loads and the frequency-tidal volume pattern during inspiratory pressure-assisted ventilation. Am Rev Respir Dis 141:327-331, 1990. (1990)

5) MacIntyre NR, Ho LI. Effects of initial flow rate and breath termination criteria on pressure support ventilation. Chest 99:134-138, 1991. (1991)

7) MacIntyre NR, McConnell R, Cheng KC, Sane A. Pressure limited breaths improve flow dys-synchrony during assisted ventilation. Crit. Care Med.. 1997 (in press) (1997)

2) MacIntyre NR, Nadel JA. Regional diffusing capacity in normal lungs during a slow exhalation. J Appl Physiol 52:1487-1492, 1982. (1982)

3) MacIntyre NR, Leatherman NE, Deitz JL, Wagoner R, Friedman M. Distribution and uptake of helium, carbon monoxide, and acetylene in the lungs during high frequency oscillary ventilation. Respir Physiol 63:201-212, 1986. (1986)

6) MacIntyre NR, McConnell R, Cheng KC. Applied PEEP reduces the inspiratory load of intrinsic PEEP during pressure support. Chest 1997; 111:188-193. (1997)