Joseph P. Mathew, MD

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Services

• Anesthesiology

Department / Division:
Anesthesiology / Anesthesiology

Address:
DUMC 3094
Durham, NC 27710

Office Telephone:
919-681-6752

Fax Telephone:
919-681-4978

• MD, University of Texas Southwestern Medical School, 1986

• Anesthesiology, Yale-New Haven Hospital (Connecticut), 1987-1990

• Cardiovascular Anesthesiology, Yale-New Haven Hospital (Connecticut), 1990-1991

Clinical Interests:
Cardiovascular anesthesiology

Research Interests:
Current research interests include:
1. The relationship between the inflammatory and pro-coagulant responses occurring within the cerebral circulation and short- and long-term neurocognitive function.
2. The association between genotype and neurocognitive outcome after CABG surgery.
3. Clinical utility of intraoperative myocardial contrast echocardiography.
4. Continuing quality improvement in intraoperative echocardiography.
5. Atrial fibrillation following cardiopulmonary bypass.

Representative Publications:
Mathew JP, Rinder HM, Smith BR, Newman MF, Rinder CS. Transcerebral platelet activation after aortic cross-clamp release is linked to neurocognitive decline. Ann Thorac Surg. 2006 May;81(5):1644-9. (2006) Abstract

Mathew JP, Shernan SK, White WD, Fitch JC, Chen JC, Bell L, Newman MF. Preliminary report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery. Stroke. 2004 Oct;35(10):2335-9. (2004) Abstract

Mathew JP, Fontes ML, Tudor IC, Ramsay J, Duke P, Mazer CD, Barash PG, Hsu PH, Mangano DT, , . A multicenter risk index for atrial fibrillation after cardiac surgery. JAMA. 2004 Apr 14;291(14):1720-9. (2004) Abstract

Mathew JP, Grocott HP, Phillips-Bute B, Stafford-Smith M, Laskowitz DT, Rossignol D, Blumenthal JA, Newman MF, , . Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery. Stroke. 2003 Feb;34(2):508-13. (2003) Abstract

Mathew JP, Parks R, Savino JS, Friedman AS, Koch C, Mangano DT, Browner WS. Atrial fibrillation following coronary artery bypass graft surgery: predictors, outcomes, and resource utilization. MultiCenter Study of Perioperative Ischemia Research Group. JAMA. 1996 Jul 24-31;276(4):300-6. (1996) Abstract