Laura E. Schanberg, MD

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Locations

• Duke Lupus Clinic

Co-Chief

Department / Division:
Pediatrics / Rheumatology

Address:
DUMC 3212
Durham, NC 27710

Appointment Telephone:
(919) 668-4000

Office Telephone:
(919) 684-6575

Fax Telephone:
(919) 684-6616

• M.D., Duke University School of Medicine, North Carolina, 1984

• Pediatrics, Duke University Medical Center, North Carolina, 1984-1987

• Pediatric Rheumatology, Duke University Medical Center, North Carolina, 1987-1991

Clinical Interests:
Pediatric rheumatic diseases, pediatric systemic lupus erythematosus, pain in children with juvenile rheumatoid arthritis, musculoskeletal pain syndromes including juvenile fibromyalgia

Research Interests:
I am involved in both hypothesis driven clinical research as well as clinical trials, both of which are described below.  

My research team consists of health psychologists, medical fellows, and graduate students in clinical psychology.  Most broadly, the research team has interests in studying stress and coping processes in children with chronic disease and their families.  Particular interests include describing the pain experience of children with chronic arthritis and the role of parental processes in child adjustment to chronic disease.

The research team has several ongoing active research projects.  These include a recently NIH funded study of daily pain in children with arthritis using an electronic device.  This study is investigating the daily pain of children with arthritis in real time and their responses to pain, including activity and school function, as well as emotional regulation.  In addition, parents will also record their responses to their child's pain in real time using a similar electronic device.  We also continue data analysis of a paper diary study of stress, mood and disease activity in children with juvenile rheumatoid arthritis. A specific goal of the diary study is to determine the relationships of child daily ratings of stress and mood with measures of pain, physical disability, psychological distress, and worsening disease as measured clinically and with biological markers of disease and immune activation.  This study is investigating the role of stress responsive hormones, such as prolactin and cortisol, and pain coping efficacy as mechanisms by which child stress and mood influence immune activation and worsening disease. Other ongoing projects include research conducted as part of the Pediatric Pain Clinic, which is a multidisciplinary clinic servicing children with chronic pain conditions.

I am also active in the several clinic trials in pediatric rheumatology.  I am the Principal Investigator for an NIH funded 21 center interventional trial entitled Prevention of Cardiovascular Complications of SLE: Atherosclerosis Prevention in Pediatric Lupus (APPLE) in conjunction with the Duke Clinical Research Institute (DCRI) and the Childhood Arthritis and Rheumatology Research Association (CARRA).  This trial which has completely enrolled with 221 participants is studying the efficacy and safety of statin therapy in children with SLE.  We are interested in both the anti-inflammatory and lipid-lowering effects of statins and how these may impact on the health status of children with SLE.  We are currently analyzing the baseline data with final results from the trial available in spring of 2010.  In addition, I am the DCRI Principal Investigator for the RAPPORT trial, a multicenter clinical trial studying the efficacy of rilonacept, a biologic agent that blocks interleukin 1 activity, in treating systemic-onset juvenile idiopathic arthritis.  I lead the safety, data management, and data analysis aspects of RAPPORT.  Enrollment for this trial will being in fall 2008 and continue for 2 years.  As part of RAPPORT, we will be looking at the role of pain and disease symptoms as markers of response to medication, as well as more conventional outcome measures.

Representative Publications:
Schanberg LE, Keefe FJ, Lefebvre JC, Kredich DW, Gil KM. Social context of pain in children with Juvenile Primary Fibromyalgia Syndrome: parental pain history and family environment. Clin J Pain. 1998 Jun;14(2):107-15. (1998) Abstract

Schanberg LE, Sandstrom MJ, Starr K, Gil KM, Lefebvre JC, Keefe FJ, Affleck G, Tennen H. The relationship of daily mood and stressful events to symptoms in juvenile rheumatic disease. Arthritis Care Res. 2000 Feb;13(1):33-41. (2000) Abstract

Schanberg LE, Keefe FJ, Lefebvre JC, Kredich DW, Gil KM. Pain coping strategies in children with juvenile primary fibromyalgia syndrome: correlation with pain, physical function, and psychological distress. Arthritis Care Res. 1996 Apr;9(2):89-96. (1996) Abstract

Schanberg LE, Anthony KK, Gil KM, Lefebvre JC, Kredich DW, Macharoni LM. Family pain history predicts child health status in children with chronic rheumatic disease. Pediatrics. 2001 Sep;108(3):E47. (2001) Abstract

Schanberg LE, Lefebvre JC, Keefe FJ, Kredich DW, Gil KM. Pain coping and the pain experience in children with juvenile chronic arthritis. Pain. 1997 Nov;73(2):181-9. (1997) Abstract

Schanberg LE. Widespread pain in children: when is it pathologic? Arthritis Rheum. 2003 Sep;48(9):2402-5. (2003) Abstract

Sandstrom MJ, Schanberg LE. Peer rejection, social behavior, and psychological adjustment in children with juvenile rheumatic disease.  J Pediatr Psychol.  2004 Jan-Feb;29(1):29-34. (2004) Abstract

Schanberg LE, Anthony KK, Gil KM, Maurin EC. Daily pain and symptoms in children with polyarticular arthritis. Arthritis Rheum. 2003 May;48(5):1390-7. (2003) Abstract

Anthony KK, Gil KM, Schanberg LE. Brief report: Parental perceptions of child vulnerability in children with chronic illness.  J Pediatr Psychol.  2003 Apr-May;28(3):185-90. (2003) Abstract

Anthony KK, Schanberg LE. Pain in children with arthritis: a review of the current literature. Arthritis Rheum. 2003 Apr 15;49(2):272-9. (2003) Abstract

Ardoin SP, Sandborg C, Schanberg LE. Management of dyslipidemia in children and adolescents with systemic lupus erythematosus. Lupus. 2007;16(8):618-26. (2007) Abstract

Schanberg LE, Sandborg C. Dyslipoproteinemia and premature atherosclerosis in pediatric systemic lupus erythematosus. Curr Rheumatol Rep. 2004 Dec;6(6):425-33. (2004) Abstract

Schanberg LE, Gil KM, Anthony KK, Yow E, Rochon J. Pain, stiffness, and fatigue in juvenile polyarticular arthritis: contemporaneous stressful events and mood as predictors. Arthritis Rheum. 2005 Apr;52(4):1196-204. (2005) Abstract

Anthony KK, Schanberg LE. Assessment and management of pain syndromes and arthritis pain in children and adolescents. Rheum Dis Clin North Am. 2007 Aug;33(3):625-60. (2007) Abstract

Ardoin SP, Schanberg LE. The management of pediatric systemic lupus erythematosus. Nat Clin Pract Rheumatol. 2005 Dec;1(2):82-92. (2005) Abstract

Kimura Y, Walco GA, Sugarman E, Conte PM, Schanberg LE. Treatment of pain in juvenile idiopathic arthritis: a survey of pediatric rheumatologists. Arthritis Rheum. 2006 Feb 15;55(1):81-5. (2006) Abstract