Vice Chair, Department of Radiology

• Radiology / Pediatric Radiology
• Pediatrics / Radiology

Address:
DUMC 3808
Durham, NC 27710

Appointment Telephone:
919-684-7289

Office Telephone:
919-684-7289

Fax Telephone:
919-684-7127

• MD, University of South Florida College of Medicine, 1975

• Pediatrics, Children's Hospital Medical Center (Ohio), 1975-1977
• Pediatric Cardiology, Children's Hospital Medical Center (Ohio), 1977-1980
• Radiology, University of Cincinnati (Ohio), 1983-1986

• Pediatric Radiology, Children's Hospital Medical Center (Ohio), 1986-1987

Clinical Interests:
Radiographic imaging and diagnosis in pediatric patients

Research Interests:
Bisset GS III, Charles C, Ware R, Kinney T, Netts J: "Phosphorus-31 Magnetic Resonance Spectroscopy of Muscle Metabolism in Patients with Sickle Cell Disease Prior To and Following Isovolemic Exchange Transfusion".

1. Purpose
The purpose of this study is to evaluate the effects of transfusion on skeletal muscle energy metabolism in patients with sickle cell disease.

2. Objective
The objective of this study is to determine whether transfusional therapy will affect tissue oxygen delivery and this the muscle bioenergetics in this group of patients.  This information may be utilized to develop more rational approached to transfusion therapy.  The primary, one-tailed hypothesis is that replacement of sickle cells by more deformable normal red blood cells will result in improved tissue oxygenation and substrate utilization within peripheral musculature.

Representative Publications:
Bisset GS III, Charles C, Ware R, Kinney T, Netts J: "Phosphorus-31 Magnetic Resonance Spectroscopy of Muscle Metabolism in Patients with Sickle Cell Disease Prior To and Following Isovolemic Exchange Trasfusion".