James M. Grichnik, MD, PhD

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Services

• Dermatology
• Skin Cancer

Department / Division:
Medicine / Dermatology

Address:
DUMC 3135
Durham, NC 27710

Appointment Telephone:
(919) 684-3432

Office Telephone:
(919) 684-3270

Fax Telephone:
(919) 684-3002

• M.D., Harvard School of Medicine, Massachusetts,1990

• Internal Medicine, Beth Israel, Massachusetts, 1990-1991
• Dermatology, Duke University Medical Center, North Carolina, 1991-1994

• Ph.D., Department of Cell Biology, Baylor College of Medicine, Texas, 1988

Clinical Interests:
Pigmented lesion clinic, disorders of melanocytes, melanoma, dysplastic nevi (atypical moles)

Research Interests:
The research in this laboratory focuses on the regulatory biology of melanocytes as relevant to melanocytic disease processes.  Disorders of melanocyte regulation can result in disease processes in which melanocytes are lost, as in vitiligo, in which too many melanocytes are present, as in moles or nevi, or in which the melanocytes have become malignant, as in melanoma.  Although melanocytes have been studied extensively in vitro, the complex cellular regulatory mechanisms controlling cutaneous melanocyte cell numbers and state of activity within the skin are still not well understood.  Our current efforts are focused on the potential role of melanocyte stem cells in normal and abnormal melanocytic biology.

Clinically, we are focused on efforts to allow the early detection of melanoma utilizing digital baseline skin images and surface microscopy.

Through our basic science research efforts, we have successfully competed for national awards and have been recognized for clinical expertise by appointment to a national committee for melanoma guidelines.

Key Words: melanoma, melanocyte, cancer, aging, stem cell factor, apoptosis KIT.

Representative Publications:
Grichnik JM. Difficult early melanomas. Dermatol Clin. 2001 Apr;19(2):319-25. (2001) Abstract

Grichnik JM, Burch JA, Burchette J, Shea CR. The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasis. J Invest Dermatol. 1998 Aug;111(2):233-8. (1998) Abstract

Grichnik JM, Ali WN, Burch JA, Byers JD, Garcia CA, Clark RE, Shea CR. KIT expression reveals a population of precursor melanocytes in human skin. J Invest Dermatol. 1996 May;106(5):967-71. (1996) Abstract

Whited JD, Grichnik JM. The rational clinical examination. Does this patient have a mole or a melanoma? JAMA. 1998 Mar 4;279(9):696-701. (1998) Abstract

Grichnik JM, Crawford J, Jimenez F, Kurtzberg J, Buchanan M, Blackwell S, Clark RE, Hitchcock MG. Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients. J Am Acad Dermatol. 1995 Oct;33(4):577-83. (1995) Abstract

Sober AJ, Chuang TY, Duvic M, Farmer ER, Grichnik JM, Halpern AC, Ho V, Holloway V, Hood AF, Johnson TM, Lowery BJ, . Guidelines of care for primary cutaneous melanoma. J Am Acad Dermatol. 2001 Oct;45(4):579-86. (2001) Abstract

Owen SA, Sanders LL, Edwards LJ, Seigler HF, Tyler DS, Grichnik JM. Identification of higher risk thin melanomas should be based on Breslow depth not Clark level IV. Cancer. 2001 Mar 1;91(5):983-91. (2001) Abstract

Grichnik JM. Dermoscopy of melanocytic neoplasms: subpatterns of melanoma. Arch Dermatol. 2003 Aug;139(8):1104. (2003) Abstract

Lucas CR, Sanders LL, Murray JC, Myers SA, Hall RP, Grichnik JM. Early melanoma detection: nonuniform dermoscopic features and growth. J Am Acad Dermatol. 2003 May;48(5):663-71. (2003) Abstract

Argenziano G, Soyer HP, Chimenti S, Talamini R, Corona R, Sera F, Binder M, Cerroni L, De Rosa G, Ferrara G, Hofmann-Wellenhof R, Landthaler M, Menzies SW, Pehamberger H, Piccolo D, Rabinovitz HS, Schiffner R, Staibano S, Stolz W, Bartenjev I, Blum A, Braun R, Cabo H, Carli P, De Giorgi V, Fleming MG, Grichnik JM, Grin CM, Halpern AC, Johr R, Katz B, Kenet RO, Kittler H, Kreusch J, Malvehy J, Mazzocchetti G, Oliviero M, Ozdemir F, Peris K, Perotti R, Perusquia A, Pizzichetta MA, Puig S, Rao B, Rubegni P, Saida T, Scalvenzi M, Seidenari S, Stanganelli I, Tanaka M, Westerhoff K, Wolf IH, Braun-Falco O, Kerl H, Nishikawa T, Wolff K, Kopf AW. Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet. J Am Acad Dermatol. 2003 May;48(5):679-93. (2003) Abstract

Grichnik JM, Burch JA, Schulteis RD, Shan S, Liu J, Darrow TL, Vervaert CE, Seigler HF. Melanoma, a tumor based on a mutant stem cell? J Invest Dermatol. 2006 Jan;126(1):142-53. (2006) Abstract

Grichnik JM. Dermoscopy of melanocytic neoplasms: subpatterns of dysplastic/atypical nevi. Arch Dermatol. 2004 Jan;140(1):142. (2004) Abstract

Grichnik JM. Dermoscopy of melanocytic neoplasms: familial patterns. Arch Dermatol. 2004 May;140(5):642. (2004) Abstract

Grichnik JM. Kit and melanocyte migration. J Invest Dermatol. 2006 May;126(5):945-7. (2006) Abstract