Joanne Kurtzberg, MD

Related Content

Services

• Pediatric Blood and Marrow Transplant
• Pediatric Cancer

Chief

Department / Division:
Pediatrics / Blood and Marrow Transplantation

Address:
DUMC 3350
Durham, NC 27710

Appointment Telephone:
919-668-1100

Office Telephone:
919-668-1119

Fax Telephone:
919-668-1183

• MD, New York Medical College, 1976

• Pediatrics, Upstate Medical Center, Syracuse (New York), 1977-1979

• Pediatric Hematology/Oncology, Upstate Medical Center (New York), 1979-1980
• Pediatric Hematology/Oncology, Duke University Medical Center, 1980-1983

Clinical Interests:
Umbilical cord blood transplantation, nucleoside therapy, T-cell ALL, asparaginase, ITP, aplastic anemia, BM and UCB transplantation, growth factor therapy, hematopoiesis, transplantation therapy for inborn errors of metabolism, immunodeficiency syndromes, congenital marrow failure syndromes, and hemoglobinopathies

Research Interests:
Dr.  Kurtzberg conducts both clinical and laboratory-based translational research efforts, all involving various aspects of normal and malignant hematopoiesis. In the laboratory, her early work focused on studies  determining the mechanisms that regulate the choice between the various pathways of differentiation available to the pluripotent  hematopoietic stem cell. Her laboratory established a CD7+ cell line, DU.528, capable of multilineage differentiation as well as self-renewal, and subsequently described  the aggresive  leukemic syndrome of CD7+ALL and demonstrated that a normal counterpart of  the CD7+, TN malignant cell can be isolated from postnatal human thymus, bone marrow,  umbilical cord blood and G-CSF mobilized peripheral blood progenitor cells.  The leukemic  CD7+ cell  has been established  in model systems nude and SCID mice where direct IL2-cytotoxicity has been demonstrated.  The mechanism of IL2-induced cytotoxicity is currently a  major focus of  work in the laboratory.  One focus of Dr. Kurtzberg's translational research is the  use of novel deoxynucleosides to purge normal and malignant T-cells from human bone marrow.  She has also played an important role in the development of PEG-L Asparaginase and Nelarabine, two novel antileukemia drugs that are now used routinely in the clinic.  Dr. Kurtzberg is active in the Children's Oncology Group and coordinated the ALinC 16 high risk study for children with newly diagnosed B-lineage acute lymphoblastic leukemia (ALL) as well as relapsed studies for children with T- and B-lineage ALL.  Over the past 2 decades, Dr. Kurtzberg pioneered and is investigating the use of banked umbilical cord  blood as an alternative stem cell source for unrelated marrow transplantation. She was awarded with a banking and transplant center contract from NHLBI for 1996-2005, to establish the Carolinas Cord Blood Bank (CCBB)at Duke and was the PI on the cord blood transplantation study (COBLT) in children with hematological malignancies and inborn errors of metabolism.   More recently, the CCBB was awarded a contract from HRSA to become a member bank of the National Cord Blood Inventory (NCBI) of the CW Bill Young Cell Transplantation Program after legislation was passed in 2005 to establish this network.  Dr. Kurtzberg is also the Duke PI for the NIH-sponsored, Blood and Marrow Transplant Clinical Trials Network (BMT-CTN) and the PI on a national trial comparing single and double cord blood transplantation in children with hematological malignancies.   Under Dr. Kurtzberg's leadership, Duke has established an internationally known children's transplant program which currrently treats children with cancer, blood disorders, immune deficiencies, hemoglobinopathies and inherited metabolic diseases.  The program is also performing translational research testing cord blood expansion, cellular targeted therapies and tissue repair and regeneration.

Representative Publications:
Laughlin MJ, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE, Gerson SL, Lazarus HM, Cairo M, Stevens CE, Rubinstein P, Kurtzberg J. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med. 2001 Jun 14;344(24):1815-22. (2001) Abstract

Kurtzberg J, Laughlin M, Graham ML, Smith C, Olson JF, Halperin EC, Ciocci G, Carrier C, Stevens CE, Rubinstein P. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med. 1996 Jul 18;335(3):157-66. (1996) Abstract

Kurtzberg J, Waldmann TA, Davey MP, Bigner SH, Moore JO, Hershfield MS, Haynes BF. CD7+, CD4-, CD8- acute leukemia: a syndrome of malignant pluripotent lymphohematopoietic cells. Blood. 1989 Feb;73(2):381-90. (1989) Abstract

Kurtzberg J, Denning SM, Nycum LM, Singer KH, Haynes BF. Immature human thymocytes can be driven to differentiate into nonlymphoid lineages by cytokines from thymic epithelial cells. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7575-9. (1989) Abstract